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Differences in Origin of Reactive Microglia in Bone Marrow Chimeric Mouse and Rat After Transient Global Ischemia.

Lambertsen, Kate L; Deierborg, Tomas LU ; Gregersen, Rikke; Clausen, Bettina H; Wirenfeldt, Martin; Nielsen, Helle H; Dalmau, Ishar; Diemer, Nils H; Dagnaes-Hansen, Frederik and Johansen, Flemming F, et al. (2011) In Journal of Neuropathology and Experimental Neurology 70(6). p.481-494
Abstract
Current understanding of microglial involvement in disease is influenced by the observation that recruited bone marrow (BM)-derived cells contribute to reactive microgliosis in BM-chimeric mice. In contrast, a similar phenomenon has not been reported for BM-chimeric rats. We investigated the recruitment and microglial transformation of BM-derived cells in radiation BM-chimeric mice and rats after transientglobal cerebral ischemia, which elicits a characteristic microglialreaction. Both species displayed microglial hyperplasia and rod cell transformation in the hippocampal CA1 region. In mice, a subpopulation of lesion-reactive microglia originated from transformed BM-derived cells. By contrast, no recruitment or microglial transformation... (More)
Current understanding of microglial involvement in disease is influenced by the observation that recruited bone marrow (BM)-derived cells contribute to reactive microgliosis in BM-chimeric mice. In contrast, a similar phenomenon has not been reported for BM-chimeric rats. We investigated the recruitment and microglial transformation of BM-derived cells in radiation BM-chimeric mice and rats after transientglobal cerebral ischemia, which elicits a characteristic microglialreaction. Both species displayed microglial hyperplasia and rod cell transformation in the hippocampal CA1 region. In mice, a subpopulation of lesion-reactive microglia originated from transformed BM-derived cells. By contrast, no recruitment or microglial transformation of BM-derived cells was observed in BM-chimeric rats. These results suggest that reactive microglia in rats originate from resident microglia, whereas they have a mixed BM-derived and resident origin in mice, depending on the severity of ischemic tissue damage. (Less)
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publication status
published
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Journal of Neuropathology and Experimental Neurology
volume
70
issue
6
pages
481 - 494
publisher
American Association of Neuropathologists
external identifiers
  • WOS:000290751700007
  • PMID:21572335
  • Scopus:79957472286
ISSN
1554-6578
DOI
10.1097/NEN.0b013e31821db3aa
language
English
LU publication?
yes
id
bfceca6f-54f0-414e-97c3-f24e7a997084 (old id 1972579)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/21572335?dopt=Abstract
date added to LUP
2011-06-07 19:47:30
date last changed
2016-10-13 04:25:54
@misc{bfceca6f-54f0-414e-97c3-f24e7a997084,
  abstract     = {Current understanding of microglial involvement in disease is influenced by the observation that recruited bone marrow (BM)-derived cells contribute to reactive microgliosis in BM-chimeric mice. In contrast, a similar phenomenon has not been reported for BM-chimeric rats. We investigated the recruitment and microglial transformation of BM-derived cells in radiation BM-chimeric mice and rats after transientglobal cerebral ischemia, which elicits a characteristic microglialreaction. Both species displayed microglial hyperplasia and rod cell transformation in the hippocampal CA1 region. In mice, a subpopulation of lesion-reactive microglia originated from transformed BM-derived cells. By contrast, no recruitment or microglial transformation of BM-derived cells was observed in BM-chimeric rats. These results suggest that reactive microglia in rats originate from resident microglia, whereas they have a mixed BM-derived and resident origin in mice, depending on the severity of ischemic tissue damage.},
  author       = {Lambertsen, Kate L and Deierborg, Tomas and Gregersen, Rikke and Clausen, Bettina H and Wirenfeldt, Martin and Nielsen, Helle H and Dalmau, Ishar and Diemer, Nils H and Dagnaes-Hansen, Frederik and Johansen, Flemming F and Keating, Armand and Finsen, Bente},
  issn         = {1554-6578},
  language     = {eng},
  number       = {6},
  pages        = {481--494},
  publisher    = {ARRAY(0xa7ac478)},
  series       = {Journal of Neuropathology and Experimental Neurology},
  title        = {Differences in Origin of Reactive Microglia in Bone Marrow Chimeric Mouse and Rat After Transient Global Ischemia.},
  url          = {http://dx.doi.org/10.1097/NEN.0b013e31821db3aa},
  volume       = {70},
  year         = {2011},
}