Differences in Origin of Reactive Microglia in Bone Marrow Chimeric Mouse and Rat After Transient Global Ischemia.
(2011) In Journal of Neuropathology and Experimental Neurology 70(6). p.481-494- Abstract
- Current understanding of microglial involvement in disease is influenced by the observation that recruited bone marrow (BM)-derived cells contribute to reactive microgliosis in BM-chimeric mice. In contrast, a similar phenomenon has not been reported for BM-chimeric rats. We investigated the recruitment and microglial transformation of BM-derived cells in radiation BM-chimeric mice and rats after transientglobal cerebral ischemia, which elicits a characteristic microglialreaction. Both species displayed microglial hyperplasia and rod cell transformation in the hippocampal CA1 region. In mice, a subpopulation of lesion-reactive microglia originated from transformed BM-derived cells. By contrast, no recruitment or microglial transformation... (More)
- Current understanding of microglial involvement in disease is influenced by the observation that recruited bone marrow (BM)-derived cells contribute to reactive microgliosis in BM-chimeric mice. In contrast, a similar phenomenon has not been reported for BM-chimeric rats. We investigated the recruitment and microglial transformation of BM-derived cells in radiation BM-chimeric mice and rats after transientglobal cerebral ischemia, which elicits a characteristic microglialreaction. Both species displayed microglial hyperplasia and rod cell transformation in the hippocampal CA1 region. In mice, a subpopulation of lesion-reactive microglia originated from transformed BM-derived cells. By contrast, no recruitment or microglial transformation of BM-derived cells was observed in BM-chimeric rats. These results suggest that reactive microglia in rats originate from resident microglia, whereas they have a mixed BM-derived and resident origin in mice, depending on the severity of ischemic tissue damage. (Less)
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https://lup.lub.lu.se/record/1972579
- author
- organization
- publishing date
- 2011
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Neuropathology and Experimental Neurology
- volume
- 70
- issue
- 6
- pages
- 481 - 494
- publisher
- American Association of Neuropathologists
- external identifiers
-
- wos:000290751700007
- pmid:21572335
- scopus:79957472286
- ISSN
- 1554-6578
- DOI
- 10.1097/NEN.0b013e31821db3aa
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Neuronal Survival (013212041)
- id
- bfceca6f-54f0-414e-97c3-f24e7a997084 (old id 1972579)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/21572335?dopt=Abstract
- date added to LUP
- 2016-04-04 09:12:02
- date last changed
- 2022-02-06 01:52:22
@article{bfceca6f-54f0-414e-97c3-f24e7a997084, abstract = {{Current understanding of microglial involvement in disease is influenced by the observation that recruited bone marrow (BM)-derived cells contribute to reactive microgliosis in BM-chimeric mice. In contrast, a similar phenomenon has not been reported for BM-chimeric rats. We investigated the recruitment and microglial transformation of BM-derived cells in radiation BM-chimeric mice and rats after transientglobal cerebral ischemia, which elicits a characteristic microglialreaction. Both species displayed microglial hyperplasia and rod cell transformation in the hippocampal CA1 region. In mice, a subpopulation of lesion-reactive microglia originated from transformed BM-derived cells. By contrast, no recruitment or microglial transformation of BM-derived cells was observed in BM-chimeric rats. These results suggest that reactive microglia in rats originate from resident microglia, whereas they have a mixed BM-derived and resident origin in mice, depending on the severity of ischemic tissue damage.}}, author = {{Lambertsen, Kate L and Deierborg, Tomas and Gregersen, Rikke and Clausen, Bettina H and Wirenfeldt, Martin and Nielsen, Helle H and Dalmau, Ishar and Diemer, Nils H and Dagnaes-Hansen, Frederik and Johansen, Flemming F and Keating, Armand and Finsen, Bente}}, issn = {{1554-6578}}, language = {{eng}}, number = {{6}}, pages = {{481--494}}, publisher = {{American Association of Neuropathologists}}, series = {{Journal of Neuropathology and Experimental Neurology}}, title = {{Differences in Origin of Reactive Microglia in Bone Marrow Chimeric Mouse and Rat After Transient Global Ischemia.}}, url = {{http://dx.doi.org/10.1097/NEN.0b013e31821db3aa}}, doi = {{10.1097/NEN.0b013e31821db3aa}}, volume = {{70}}, year = {{2011}}, }