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Permeability of peritoneal and glomerular capillaries: what are the differences according to pore theory?

Rippe, Bengt LU and Davies, Simon (2011) In Peritoneal Dialysis International 31(3). p.249-258
Abstract
Pore and fiber-matrix theory can both be used to model the peritoneal and glomerular filtration barriers in an attempt to shed light on their differing structure-function relationships. The glomerular filtration barrier (GFB) is structurally more specialized, morphologically complex, and also highly dynamic; but paradoxically, because of its uniformity, it conforms more closely to the predictions of pore theory than does the peritoneum, and it in fact resembles a more simple synthetic membrane. Compared with the peritoneal capillary wall, the GFB has no transcellular "third" pores (aquaporins), and it is far less leaky and more size-selective to proteins, mainly as a result of having far fewer "large" pores. It does have charge-selective... (More)
Pore and fiber-matrix theory can both be used to model the peritoneal and glomerular filtration barriers in an attempt to shed light on their differing structure-function relationships. The glomerular filtration barrier (GFB) is structurally more specialized, morphologically complex, and also highly dynamic; but paradoxically, because of its uniformity, it conforms more closely to the predictions of pore theory than does the peritoneum, and it in fact resembles a more simple synthetic membrane. Compared with the peritoneal capillary wall, the GFB has no transcellular "third" pores (aquaporins), and it is far less leaky and more size-selective to proteins, mainly as a result of having far fewer "large" pores. It does have charge-selective properties, although these are considered much less important in excluding albumin than was once thought, and it is also able to select polymers according to their shape and flexibility. Even this property might reflect the relative uniformity of the GFB, which has a high diffusion area and short diffusion distances, compared with the peritoneal barrier, which behaves more like a gel filtration column. Furthermore, the length of the diffusion path across the peritoneal membrane is much greater for small solutes, given the relatively high ultrafiltration coefficient for that membrane compared with the GFB-a situation that reflects both the tortuosity of the interendothelial clefts and the distribution of peritoneal capillaries within the interstitium. These comparisons reveal the peritoneal barrier as a relatively complex structure to model; and yet this model may be more representative of the general microcirculation, and thus shed light on systemic endothelial function in renal failure. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Peritoneal Dialysis International
volume
31
issue
3
pages
249 - 258
publisher
Multimed Inc.
external identifiers
  • WOS:000290406900003
  • PMID:21555410
  • Scopus:84856137894
ISSN
1718-4304
DOI
10.3747/pdi.2010.00124
language
English
LU publication?
yes
id
47dec135-8686-4824-9f32-32796d08e35d (old id 1973031)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/21555410?dopt=Abstract
date added to LUP
2011-06-07 15:17:01
date last changed
2016-10-13 04:26:19
@misc{47dec135-8686-4824-9f32-32796d08e35d,
  abstract     = {Pore and fiber-matrix theory can both be used to model the peritoneal and glomerular filtration barriers in an attempt to shed light on their differing structure-function relationships. The glomerular filtration barrier (GFB) is structurally more specialized, morphologically complex, and also highly dynamic; but paradoxically, because of its uniformity, it conforms more closely to the predictions of pore theory than does the peritoneum, and it in fact resembles a more simple synthetic membrane. Compared with the peritoneal capillary wall, the GFB has no transcellular "third" pores (aquaporins), and it is far less leaky and more size-selective to proteins, mainly as a result of having far fewer "large" pores. It does have charge-selective properties, although these are considered much less important in excluding albumin than was once thought, and it is also able to select polymers according to their shape and flexibility. Even this property might reflect the relative uniformity of the GFB, which has a high diffusion area and short diffusion distances, compared with the peritoneal barrier, which behaves more like a gel filtration column. Furthermore, the length of the diffusion path across the peritoneal membrane is much greater for small solutes, given the relatively high ultrafiltration coefficient for that membrane compared with the GFB-a situation that reflects both the tortuosity of the interendothelial clefts and the distribution of peritoneal capillaries within the interstitium. These comparisons reveal the peritoneal barrier as a relatively complex structure to model; and yet this model may be more representative of the general microcirculation, and thus shed light on systemic endothelial function in renal failure.},
  author       = {Rippe, Bengt and Davies, Simon},
  issn         = {1718-4304},
  language     = {eng},
  number       = {3},
  pages        = {249--258},
  publisher    = {ARRAY(0xb828bd8)},
  series       = {Peritoneal Dialysis International},
  title        = {Permeability of peritoneal and glomerular capillaries: what are the differences according to pore theory?},
  url          = {http://dx.doi.org/10.3747/pdi.2010.00124},
  volume       = {31},
  year         = {2011},
}