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The correlation between regulatory conditions and antibiotic consumption within the WHO European Region

Mueller, Tanja and Östergren, Per Olof LU (2015) In Health Policy 120(8). p.9-882
Abstract

Background: In a global perspective, bacterial infections are still a major cause of morbidity and mortality; therefore, effective antibiotics are needed. However, the emergence of antibiotic resistance due to irrational use has now become a serious public health problem. Hence, the objective of this study was to analyse the association of regulatory aspects with antibiotic consumption. Methods: A data set representing 20 countries throughout the WHO European Region was chosen based on data availability so as to analyse the correlation between specific regulatory conditions and antibiotic consumption, using total consumption data for 2011 and information about national provisions regarding rational use of medicines. Linear regression... (More)

Background: In a global perspective, bacterial infections are still a major cause of morbidity and mortality; therefore, effective antibiotics are needed. However, the emergence of antibiotic resistance due to irrational use has now become a serious public health problem. Hence, the objective of this study was to analyse the association of regulatory aspects with antibiotic consumption. Methods: A data set representing 20 countries throughout the WHO European Region was chosen based on data availability so as to analyse the correlation between specific regulatory conditions and antibiotic consumption, using total consumption data for 2011 and information about national provisions regarding rational use of medicines. Linear regression models were designed in order to evaluate individual aspects as well as the overall level of regulation. Results: A high level of regulation, assessed by an overall index, was significantly correlated with lower antibiotic consumption; however, of all individual items analysed, only the presence of Standard Treatment Guidelines for hospital care as well as paediatric conditions, the non-availability of antibiotics without a prescription, and the existence of training modules for pharmacists covering rational use of medicines gave significant results, i.e. lower use of antibiotics, when regarded in isolation. Conclusion: Although national regulatory conditions intended to foster rational use of antibiotics seem to be correlated with antibiotic consumption, this association is potentially influenced by a wide range of contextual aspects.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Antibiotic resistance, Antibiotic stewardship, Antibiotics, Rational use of medicines
in
Health Policy
volume
120
issue
8
pages
9 - 882
publisher
Elsevier
external identifiers
  • Scopus:84979079557
ISSN
0168-8510
DOI
10.1016/j.healthpol.2016.07.004
language
English
LU publication?
yes
id
1c3fd9fd-0a0c-48ef-8934-ac09718f4c9e
date added to LUP
2016-09-06 13:34:52
date last changed
2016-09-20 03:02:51
@misc{1c3fd9fd-0a0c-48ef-8934-ac09718f4c9e,
  abstract     = {<p>Background: In a global perspective, bacterial infections are still a major cause of morbidity and mortality; therefore, effective antibiotics are needed. However, the emergence of antibiotic resistance due to irrational use has now become a serious public health problem. Hence, the objective of this study was to analyse the association of regulatory aspects with antibiotic consumption. Methods: A data set representing 20 countries throughout the WHO European Region was chosen based on data availability so as to analyse the correlation between specific regulatory conditions and antibiotic consumption, using total consumption data for 2011 and information about national provisions regarding rational use of medicines. Linear regression models were designed in order to evaluate individual aspects as well as the overall level of regulation. Results: A high level of regulation, assessed by an overall index, was significantly correlated with lower antibiotic consumption; however, of all individual items analysed, only the presence of Standard Treatment Guidelines for hospital care as well as paediatric conditions, the non-availability of antibiotics without a prescription, and the existence of training modules for pharmacists covering rational use of medicines gave significant results, i.e. lower use of antibiotics, when regarded in isolation. Conclusion: Although national regulatory conditions intended to foster rational use of antibiotics seem to be correlated with antibiotic consumption, this association is potentially influenced by a wide range of contextual aspects.</p>},
  author       = {Mueller, Tanja and Östergren, Per Olof},
  issn         = {0168-8510},
  keyword      = {Antibiotic resistance,Antibiotic stewardship,Antibiotics,Rational use of medicines},
  language     = {eng},
  month        = {02},
  number       = {8},
  pages        = {9--882},
  publisher    = {ARRAY(0x99cc550)},
  series       = {Health Policy},
  title        = {The correlation between regulatory conditions and antibiotic consumption within the WHO European Region},
  url          = {http://dx.doi.org/10.1016/j.healthpol.2016.07.004},
  volume       = {120},
  year         = {2015},
}