Increased Sensitivity to Broadly Neutralizing Antibodies of End-Stage Disease R5 HIV-1 Correlates with Evolution in Env Glycosylation and Charge.
(2011) In PLoS ONE 6(6).- Abstract
- Induction of broadly neutralizing antibodies, such as the monoclonal antibodies IgGb12, 2F5 and 2G12, is the objective of most antibody-based HIV-1 vaccine undertakings. However, despite the relative conserved nature of epitopes targeted by these antibodies, mechanisms underlying the sensitivity of circulating HIV-1 variants to broadly neutralizing antibodies are not fully understood. Here we have studied sensitivity to broadly neutralizing antibodies of HIV-1 variants that emerge during disease progression in relation to molecular alterations in the viral envelope glycoproteins (Env), using a panel of primary R5 HIV-1 isolates sequentially obtained before and after AIDS onset.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/2007819
- author
- organization
- publishing date
- 2011
- type
- Contribution to journal
- publication status
- published
- subject
- in
- PLoS ONE
- volume
- 6
- issue
- 6
- article number
- e20135
- publisher
- Public Library of Science (PLoS)
- external identifiers
-
- wos:000291734100005
- pmid:21698221
- scopus:79959229025
- ISSN
- 1932-6203
- DOI
- 10.1371/journal.pone.0020135
- language
- English
- LU publication?
- yes
- id
- 70cf378e-3896-4b3b-92bd-2a00cd0012af (old id 2007819)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/21698221?dopt=Abstract
- date added to LUP
- 2016-04-04 09:18:40
- date last changed
- 2022-01-29 17:16:56
@article{70cf378e-3896-4b3b-92bd-2a00cd0012af, abstract = {{Induction of broadly neutralizing antibodies, such as the monoclonal antibodies IgGb12, 2F5 and 2G12, is the objective of most antibody-based HIV-1 vaccine undertakings. However, despite the relative conserved nature of epitopes targeted by these antibodies, mechanisms underlying the sensitivity of circulating HIV-1 variants to broadly neutralizing antibodies are not fully understood. Here we have studied sensitivity to broadly neutralizing antibodies of HIV-1 variants that emerge during disease progression in relation to molecular alterations in the viral envelope glycoproteins (Env), using a panel of primary R5 HIV-1 isolates sequentially obtained before and after AIDS onset.}}, author = {{Borggren, Marie and Repits, Johanna and Sterjovski, Jasminka and Uchtenhagen, Hannes and Churchill, Melissa J and Karlsson, Anders and Albert, Jan and Achour, Adnane and Gorry, Paul R and Fenyö, Eva Maria and Jansson, Marianne}}, issn = {{1932-6203}}, language = {{eng}}, number = {{6}}, publisher = {{Public Library of Science (PLoS)}}, series = {{PLoS ONE}}, title = {{Increased Sensitivity to Broadly Neutralizing Antibodies of End-Stage Disease R5 HIV-1 Correlates with Evolution in Env Glycosylation and Charge.}}, url = {{https://lup.lub.lu.se/search/files/5289400/2172652.pdf}}, doi = {{10.1371/journal.pone.0020135}}, volume = {{6}}, year = {{2011}}, }