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A population-based investigation of the autoantibody profile in mothers of children with atrioventricular block.

Salomonsson, Stina; Dzikaite, Vijole; Zeffer, Elisabeth; Eliasson, Håkan; Ambrosi, Aurelie; Bergman, Gunnar; Fernlund, Eva; Theander, Elke LU ; Ohman, Annika and Rydberg, Annika, et al. (2011) In Scandinavian Journal of Immunology 74. p.511-517
Abstract
The objective of the study was to investigate the antigen specificity and occurrence of individual autoantibodies in mothers of children diagnosed with atrioventricular (AV) block in a nation-wide setting. Patients with AV block detected before 15 years of age were identified using national quality registries as well as a network of pediatric and adult cardiologists and rheumatologists at the six university hospitals in Sweden. Patients with gross heart malformations, surgically or infectiously induced blocks were excluded. Blood samples were obtained from the mothers and maternal autoantibody profile, including the occurrence of antibodies against Ro52, Ro60, La, SmB, SmD, RNP-70k, RNP-A, RNP-C, CENP-C, Scl-70, Jo-1, ribosomal RNP and... (More)
The objective of the study was to investigate the antigen specificity and occurrence of individual autoantibodies in mothers of children diagnosed with atrioventricular (AV) block in a nation-wide setting. Patients with AV block detected before 15 years of age were identified using national quality registries as well as a network of pediatric and adult cardiologists and rheumatologists at the six university hospitals in Sweden. Patients with gross heart malformations, surgically or infectiously induced blocks were excluded. Blood samples were obtained from the mothers and maternal autoantibody profile, including the occurrence of antibodies against Ro52, Ro60, La, SmB, SmD, RNP-70k, RNP-A, RNP-C, CENP-C, Scl-70, Jo-1, ribosomal RNP and histones was investigated in 193 mothers of children with AV block by immunoblotting and ELISA. Autoantibody reactivity was detected in 48% (93/193) of the mothers of children with AV block. In autoantibody-positive mothers, the vast majority, 95% (88/93), had antibodies against Ro52, while 63% (59/93) had autoantibodies to Ro60 and 58% (54/93) had autoantibodies to La. In addition, 13% (12/93) of the autoantibody-positive mothers had antibodies to other investigated antigens besides Ro52, Ro60 and La, and of these anti-histone antibodies were most commonly represented, detected in 8% (7/93) of the mothers. In conclusion, this Swedish population-based study confirm that maternal autoantibodies may associate with heart block in the child. Further, our data demonstrate a dominant role of Ro52 antibodies in association with AV block. (Less)
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published
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Scandinavian Journal of Immunology
volume
74
pages
511 - 517
publisher
Wiley-Blackwell
external identifiers
  • WOS:000296081100012
  • PMID:21815910
  • Scopus:80053540936
ISSN
1365-3083
DOI
10.1111/j.1365-3083.2011.02610.x
language
English
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yes
id
8c6d3043-dd4f-4aa2-8535-d7c325f678f5 (old id 2151465)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/21815910?dopt=Abstract
date added to LUP
2011-09-04 16:26:23
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2016-11-20 04:21:43
@misc{8c6d3043-dd4f-4aa2-8535-d7c325f678f5,
  abstract     = {The objective of the study was to investigate the antigen specificity and occurrence of individual autoantibodies in mothers of children diagnosed with atrioventricular (AV) block in a nation-wide setting. Patients with AV block detected before 15 years of age were identified using national quality registries as well as a network of pediatric and adult cardiologists and rheumatologists at the six university hospitals in Sweden. Patients with gross heart malformations, surgically or infectiously induced blocks were excluded. Blood samples were obtained from the mothers and maternal autoantibody profile, including the occurrence of antibodies against Ro52, Ro60, La, SmB, SmD, RNP-70k, RNP-A, RNP-C, CENP-C, Scl-70, Jo-1, ribosomal RNP and histones was investigated in 193 mothers of children with AV block by immunoblotting and ELISA. Autoantibody reactivity was detected in 48% (93/193) of the mothers of children with AV block. In autoantibody-positive mothers, the vast majority, 95% (88/93), had antibodies against Ro52, while 63% (59/93) had autoantibodies to Ro60 and 58% (54/93) had autoantibodies to La. In addition, 13% (12/93) of the autoantibody-positive mothers had antibodies to other investigated antigens besides Ro52, Ro60 and La, and of these anti-histone antibodies were most commonly represented, detected in 8% (7/93) of the mothers. In conclusion, this Swedish population-based study confirm that maternal autoantibodies may associate with heart block in the child. Further, our data demonstrate a dominant role of Ro52 antibodies in association with AV block.},
  author       = {Salomonsson, Stina and Dzikaite, Vijole and Zeffer, Elisabeth and Eliasson, Håkan and Ambrosi, Aurelie and Bergman, Gunnar and Fernlund, Eva and Theander, Elke and Ohman, Annika and Rydberg, Annika and Skogh, Thomas and Wållberg-Jonsson, Solveig and Elfving, Ase and Fored, Michael and Ekbom, Anders and Lundström, Ulla and Mellander, Mats and Winqvist, Ola and Sonesson, Sven-Erik and Gadler, Fredrik and Jonzon, Anders and Wahren-Herlenius, Marie},
  issn         = {1365-3083},
  language     = {eng},
  pages        = {511--517},
  publisher    = {ARRAY(0x91d1e38)},
  series       = {Scandinavian Journal of Immunology},
  title        = {A population-based investigation of the autoantibody profile in mothers of children with atrioventricular block.},
  url          = {http://dx.doi.org/10.1111/j.1365-3083.2011.02610.x},
  volume       = {74},
  year         = {2011},
}