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Cartilage matrix metabolism in osteoarthritis : markers in synovial fluid, serum, and urine

Lohmander, L. Stefan LU ; Lark, Michael W.; Dahlberg, Leif LU ; Walakovits, Lori A. and Roos, Harald LU (1992) In Clinical Biochemistry 25(3). p.167-174
Abstract

Osteoarthritis is a major cause of disability and early retirement. Yet we lack the means to diagnose the disease in its early stages or to monitor the effects of treatment on the target tissue, the joint cartilage. Neither can we identify the disease mechanisms at the tissue or cell level. Current research focuses on the use of markers of cartilage matrix metabolism in body fluids as a means to diagnose and monitor osteoarthritis. Cartilage proteoglycan, collagen and glycoprotein fragments, as well as proteinases and their inhibitors, are being suggested for this purpose. Structural information on matrix molecule fragments released into body fluids may also help to identify the enzymes active in the destruction of the cartilage, a... (More)

Osteoarthritis is a major cause of disability and early retirement. Yet we lack the means to diagnose the disease in its early stages or to monitor the effects of treatment on the target tissue, the joint cartilage. Neither can we identify the disease mechanisms at the tissue or cell level. Current research focuses on the use of markers of cartilage matrix metabolism in body fluids as a means to diagnose and monitor osteoarthritis. Cartilage proteoglycan, collagen and glycoprotein fragments, as well as proteinases and their inhibitors, are being suggested for this purpose. Structural information on matrix molecule fragments released into body fluids may also help to identify the enzymes active in the destruction of the cartilage, a central issue in osteoarthritis. © 1992 The Canadian Society of Clinical Chemists.

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Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
cartilage, collagen, metalloproteinase, osteoarthritis, proteoglycan, stromelysin, synovial fluid
in
Clinical Biochemistry
volume
25
issue
3
pages
8 pages
publisher
Elsevier
external identifiers
  • Scopus:0026656523
ISSN
0009-9120
DOI
10.1016/0009-9120(92)90250-V
language
English
LU publication?
yes
id
21517544-162c-4ab7-adc5-e0612ac3f843
date added to LUP
2016-05-04 18:22:43
date last changed
2016-08-02 15:58:46
@misc{21517544-162c-4ab7-adc5-e0612ac3f843,
  abstract     = {<p>Osteoarthritis is a major cause of disability and early retirement. Yet we lack the means to diagnose the disease in its early stages or to monitor the effects of treatment on the target tissue, the joint cartilage. Neither can we identify the disease mechanisms at the tissue or cell level. Current research focuses on the use of markers of cartilage matrix metabolism in body fluids as a means to diagnose and monitor osteoarthritis. Cartilage proteoglycan, collagen and glycoprotein fragments, as well as proteinases and their inhibitors, are being suggested for this purpose. Structural information on matrix molecule fragments released into body fluids may also help to identify the enzymes active in the destruction of the cartilage, a central issue in osteoarthritis. © 1992 The Canadian Society of Clinical Chemists.</p>},
  author       = {Lohmander, L. Stefan and Lark, Michael W. and Dahlberg, Leif and Walakovits, Lori A. and Roos, Harald},
  issn         = {0009-9120},
  keyword      = {cartilage,collagen,metalloproteinase,osteoarthritis,proteoglycan,stromelysin,synovial fluid},
  language     = {eng},
  number       = {3},
  pages        = {167--174},
  publisher    = {ARRAY(0x8c95db8)},
  series       = {Clinical Biochemistry},
  title        = {Cartilage matrix metabolism in osteoarthritis : markers in synovial fluid, serum, and urine},
  url          = {http://dx.doi.org/10.1016/0009-9120(92)90250-V},
  volume       = {25},
  year         = {1992},
}