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Fatigue in out-patients with inflammatory bowel disease is common and multifactorial.

Bager, P; Befrits, R; Wikman, O; Lindgren, Stefan LU ; Moum, B; Hjortswang, H; Hjollund, N H and Dahlerup, J F (2012) In Alimentary pharmacology & therapeutics 35. p.133-141
Abstract
Background Patients with inflammatory bowel disease (IBD) often complain of fatigue. Aim To investigate the prevalence and characteristics of fatigue among IBD out-patients in Scandinavia and to provide normative values for fatigue in IBD patients. Methods A cross-sectional study was conducted on 425 IBD patients from six out-patient centres in Denmark, Norway and Sweden. Fatigue was measured using the Multidimensional Fatigue Inventory. The patients were also screened for anaemia and iron deficiency. Each centre included approximately 5% of their IBD cohort. The patients were enrolled consecutively from the out-patient clinics, regardless of disease activity and whether the visit was scheduled. The fatigue analysis was stratified for age... (More)
Background Patients with inflammatory bowel disease (IBD) often complain of fatigue. Aim To investigate the prevalence and characteristics of fatigue among IBD out-patients in Scandinavia and to provide normative values for fatigue in IBD patients. Methods A cross-sectional study was conducted on 425 IBD patients from six out-patient centres in Denmark, Norway and Sweden. Fatigue was measured using the Multidimensional Fatigue Inventory. The patients were also screened for anaemia and iron deficiency. Each centre included approximately 5% of their IBD cohort. The patients were enrolled consecutively from the out-patient clinics, regardless of disease activity and whether the visit was scheduled. The fatigue analysis was stratified for age and gender. Results Using the 95th percentile of the score of the general population as a cut-off, approximately 44% of the patients were fatigued. When comparing the IBD patients with disease activity to the IBD patients in remission, all dimensions of fatigue were statistically significant (P < 0.05). Being anaemic or iron deficient was not associated with increased fatigue. Being a male patient with ulcerative colitis treated with corticosteroids was a strong determinant for increased fatigue. The normative ranges for IBD fatigue were calculated. Conclusions Fatigue in IBD is common regardless of anaemia or iron deficiency. Fatigue in IBD is most marked for patients <60 years of age. Stratifying for gender and age is necessary when analysing fatigue, as fatigue is expressed differently between groups. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Alimentary pharmacology & therapeutics
volume
35
pages
133 - 141
publisher
Wiley-Blackwell
external identifiers
  • WOS:000297922600014
  • PMID:22059387
  • Scopus:83555162623
ISSN
1365-2036
DOI
10.1111/j.1365-2036.2011.04914.x
language
English
LU publication?
yes
id
07a80b28-4e36-4306-b873-5542610bf070 (old id 2221050)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/22059387?dopt=Abstract
date added to LUP
2011-12-02 19:40:32
date last changed
2016-11-27 04:27:37
@misc{07a80b28-4e36-4306-b873-5542610bf070,
  abstract     = {Background Patients with inflammatory bowel disease (IBD) often complain of fatigue. Aim To investigate the prevalence and characteristics of fatigue among IBD out-patients in Scandinavia and to provide normative values for fatigue in IBD patients. Methods A cross-sectional study was conducted on 425 IBD patients from six out-patient centres in Denmark, Norway and Sweden. Fatigue was measured using the Multidimensional Fatigue Inventory. The patients were also screened for anaemia and iron deficiency. Each centre included approximately 5% of their IBD cohort. The patients were enrolled consecutively from the out-patient clinics, regardless of disease activity and whether the visit was scheduled. The fatigue analysis was stratified for age and gender. Results Using the 95th percentile of the score of the general population as a cut-off, approximately 44% of the patients were fatigued. When comparing the IBD patients with disease activity to the IBD patients in remission, all dimensions of fatigue were statistically significant (P &lt; 0.05). Being anaemic or iron deficient was not associated with increased fatigue. Being a male patient with ulcerative colitis treated with corticosteroids was a strong determinant for increased fatigue. The normative ranges for IBD fatigue were calculated. Conclusions Fatigue in IBD is common regardless of anaemia or iron deficiency. Fatigue in IBD is most marked for patients &lt;60 years of age. Stratifying for gender and age is necessary when analysing fatigue, as fatigue is expressed differently between groups.},
  author       = {Bager, P and Befrits, R and Wikman, O and Lindgren, Stefan and Moum, B and Hjortswang, H and Hjollund, N H and Dahlerup, J F},
  issn         = {1365-2036},
  language     = {eng},
  pages        = {133--141},
  publisher    = {ARRAY(0xb43ca00)},
  series       = {Alimentary pharmacology & therapeutics},
  title        = {Fatigue in out-patients with inflammatory bowel disease is common and multifactorial.},
  url          = {http://dx.doi.org/10.1111/j.1365-2036.2011.04914.x},
  volume       = {35},
  year         = {2012},
}