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Salicylamide and salicylglycine oxidovanadium complexes with insulin-mimetic properties.

Nilsson, Jessica; Shteinman, Albert A; Degerman, Eva LU ; Enyedy, Eva A; Kiss, Tamás; Behrens, Ulrich; Rehder, Dieter and Nordlander, Ebbe (2011) In Journal of Inorganic Biochemistry 105. p.1795-1800
Abstract
Reaction of N-(2-hydroxybenzyl)-N-(2-picolyl) glycine (H(2)papy) with VOSO(4) in water gives the oxidovanadium(V) oxido-bridged dimer [{(papy)(VO)}(2) μ-O)] (1). Similarly, reaction of N-(2-hydroxybenzyl) glycine (H(2)glysal) with VOSO(4) gives [(glysal)VO(H(2)O)] (2) and reaction of salicylamide (Hsalam) with VOSO(4) in methanol gives [(salam)(2)VO] (3). The crystal structure of the oxido-bridged complex 1 is reported. The insulin-mimetic activity of all three complexes was evaluated with respect to their ability to phosphorylate protein kinase B (PKB). The speciations of complexes 1 and 2 were studied over the pH range 2-10. Complex 1 shows greater stability over the whole pH range but only 2 and 3 exhibit an insulin-mimetic effect.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Inorganic Biochemistry
volume
105
pages
1795 - 1800
publisher
Elsevier
external identifiers
  • WOS:000297904900034
  • PMID:22056176
  • Scopus:82755172879
ISSN
1873-3344
DOI
10.1016/j.jinorgbio.2011.09.022
language
English
LU publication?
yes
id
e20ea554-ad72-4951-bf0f-eba9e4c20833 (old id 2221105)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/22056176?dopt=Abstract
date added to LUP
2011-12-02 19:31:13
date last changed
2016-12-04 04:41:19
@misc{e20ea554-ad72-4951-bf0f-eba9e4c20833,
  abstract     = {Reaction of N-(2-hydroxybenzyl)-N-(2-picolyl) glycine (H(2)papy) with VOSO(4) in water gives the oxidovanadium(V) oxido-bridged dimer [{(papy)(VO)}(2) μ-O)] (1). Similarly, reaction of N-(2-hydroxybenzyl) glycine (H(2)glysal) with VOSO(4) gives [(glysal)VO(H(2)O)] (2) and reaction of salicylamide (Hsalam) with VOSO(4) in methanol gives [(salam)(2)VO] (3). The crystal structure of the oxido-bridged complex 1 is reported. The insulin-mimetic activity of all three complexes was evaluated with respect to their ability to phosphorylate protein kinase B (PKB). The speciations of complexes 1 and 2 were studied over the pH range 2-10. Complex 1 shows greater stability over the whole pH range but only 2 and 3 exhibit an insulin-mimetic effect.},
  author       = {Nilsson, Jessica and Shteinman, Albert A and Degerman, Eva and Enyedy, Eva A and Kiss, Tamás and Behrens, Ulrich and Rehder, Dieter and Nordlander, Ebbe},
  issn         = {1873-3344},
  language     = {eng},
  pages        = {1795--1800},
  publisher    = {ARRAY(0x7b5a898)},
  series       = {Journal of Inorganic Biochemistry},
  title        = {Salicylamide and salicylglycine oxidovanadium complexes with insulin-mimetic properties.},
  url          = {http://dx.doi.org/10.1016/j.jinorgbio.2011.09.022},
  volume       = {105},
  year         = {2011},
}