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Effects of Optical-constants On Time-gated Transillumination of Tissue and Tissue-like Media

Andersson-Engels, Stefan LU ; Berg, Roger and Svanberg, Sune LU (1992) In Journal of Photochemistry and Photobiology, B: Biology 16(2). p.155-167
Abstract
Light transillumination was used to study structures inside turbid media. Time-gated viewing was performed to suppress multiply-scattered light and thus improve spatial resolution. We demonstrate that, for the case of scattering-dominated attenuation (scattering coefficient much greater than the absorption coefficient), the detection of early transmitted light will be practically insensitive to variations in the absorption coefficient. This is an important observation for the development of time-gated optical mammography, since optical mammography using continuous-wave light is based on increased light absorption in the tumour region caused by the neovascularization surrounding a tumour. In order to detect tumours in time-gated viewing it... (More)
Light transillumination was used to study structures inside turbid media. Time-gated viewing was performed to suppress multiply-scattered light and thus improve spatial resolution. We demonstrate that, for the case of scattering-dominated attenuation (scattering coefficient much greater than the absorption coefficient), the detection of early transmitted light will be practically insensitive to variations in the absorption coefficient. This is an important observation for the development of time-gated optical mammography, since optical mammography using continuous-wave light is based on increased light absorption in the tumour region caused by the neovascularization surrounding a tumour. In order to detect tumours in time-gated viewing it is the scattering coefficient of the tumour that must be characteristic. The scattering coefficient is measured to be lower in the tumour region than in the surrounding breast tissue for one resected breast specimen. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Photochemistry and Photobiology, B: Biology
volume
16
issue
2
pages
155 - 167
publisher
Elsevier
external identifiers
  • Scopus:0026482192
ISSN
1011-1344
DOI
10.1016/1011-1344(92)80006-H
language
English
LU publication?
yes
id
a359e6aa-d8e4-4b63-a60b-2570067f3623 (old id 2257326)
date added to LUP
2012-02-24 09:35:25
date last changed
2016-10-13 04:24:01
@misc{a359e6aa-d8e4-4b63-a60b-2570067f3623,
  abstract     = {Light transillumination was used to study structures inside turbid media. Time-gated viewing was performed to suppress multiply-scattered light and thus improve spatial resolution. We demonstrate that, for the case of scattering-dominated attenuation (scattering coefficient much greater than the absorption coefficient), the detection of early transmitted light will be practically insensitive to variations in the absorption coefficient. This is an important observation for the development of time-gated optical mammography, since optical mammography using continuous-wave light is based on increased light absorption in the tumour region caused by the neovascularization surrounding a tumour. In order to detect tumours in time-gated viewing it is the scattering coefficient of the tumour that must be characteristic. The scattering coefficient is measured to be lower in the tumour region than in the surrounding breast tissue for one resected breast specimen.},
  author       = {Andersson-Engels, Stefan and Berg, Roger and Svanberg, Sune},
  issn         = {1011-1344},
  language     = {eng},
  number       = {2},
  pages        = {155--167},
  publisher    = {ARRAY(0x8a7ac70)},
  series       = {Journal of Photochemistry and Photobiology, B: Biology},
  title        = {Effects of Optical-constants On Time-gated Transillumination of Tissue and Tissue-like Media},
  url          = {http://dx.doi.org/10.1016/1011-1344(92)80006-H},
  volume       = {16},
  year         = {1992},
}