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Clinical system for non-invasive in situ monitoring of gases in the human paranasal sinuses

Lewander, Märta LU ; Guan, Zuguang LU ; Svanberg, Katarina LU ; Svanberg, Sune LU and Svensson, Tomas LU (2009) In Optics Express 17(13). p.10849-10863
Abstract
We present a portable system for non-invasive, simultaneous sensing of molecular oxygen (O-2) and water vapor (H2O) in the human paranasal cavities. The system is based on high-resolution tunable diode laser spectroscopy (TDLAS) and digital wavelength modulation spectroscopy (dWMS). Since optical interference and non-ideal tuning of the diode lasers render signal processing complex, we focus on Fourier analysis of dWMS signals and procedures for removal of background signals. Clinical data are presented, and exhibit a significant improvement in signal-to-noise with respect to earlier work. The in situ detection limit, in terms of absorption fraction, is about 5 x 10(-5) for oxygen and 5 x 10(-4) for water vapor, but varies between patients... (More)
We present a portable system for non-invasive, simultaneous sensing of molecular oxygen (O-2) and water vapor (H2O) in the human paranasal cavities. The system is based on high-resolution tunable diode laser spectroscopy (TDLAS) and digital wavelength modulation spectroscopy (dWMS). Since optical interference and non-ideal tuning of the diode lasers render signal processing complex, we focus on Fourier analysis of dWMS signals and procedures for removal of background signals. Clinical data are presented, and exhibit a significant improvement in signal-to-noise with respect to earlier work. The in situ detection limit, in terms of absorption fraction, is about 5 x 10(-5) for oxygen and 5 x 10(-4) for water vapor, but varies between patients due to differences in light attenuation. In addition, we discuss the use of water vapor as a reference in quantification of in situ oxygen concentration in detail. In particular, light propagation aspects are investigated by employing photon time-of-flight spectroscopy. (C) 2009 Optical Society of America (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Optics Express
volume
17
issue
13
pages
10849 - 10863
publisher
OSA
external identifiers
  • PMID:19550485
  • WOS:000267761100046
  • Scopus:67649383613
ISSN
1094-4087
DOI
10.1364/OE.17.010849
language
English
LU publication?
yes
id
785d6329-b250-4897-a4c1-5233699422b2 (old id 2258750)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/19550485?dopt=Abstract
date added to LUP
2012-02-18 11:32:50
date last changed
2016-10-13 04:24:38
@misc{785d6329-b250-4897-a4c1-5233699422b2,
  abstract     = {We present a portable system for non-invasive, simultaneous sensing of molecular oxygen (O-2) and water vapor (H2O) in the human paranasal cavities. The system is based on high-resolution tunable diode laser spectroscopy (TDLAS) and digital wavelength modulation spectroscopy (dWMS). Since optical interference and non-ideal tuning of the diode lasers render signal processing complex, we focus on Fourier analysis of dWMS signals and procedures for removal of background signals. Clinical data are presented, and exhibit a significant improvement in signal-to-noise with respect to earlier work. The in situ detection limit, in terms of absorption fraction, is about 5 x 10(-5) for oxygen and 5 x 10(-4) for water vapor, but varies between patients due to differences in light attenuation. In addition, we discuss the use of water vapor as a reference in quantification of in situ oxygen concentration in detail. In particular, light propagation aspects are investigated by employing photon time-of-flight spectroscopy. (C) 2009 Optical Society of America},
  author       = {Lewander, Märta and Guan, Zuguang and Svanberg, Katarina and Svanberg, Sune and Svensson, Tomas},
  issn         = {1094-4087},
  language     = {eng},
  number       = {13},
  pages        = {10849--10863},
  publisher    = {ARRAY(0x8756f18)},
  series       = {Optics Express},
  title        = {Clinical system for non-invasive in situ monitoring of gases in the human paranasal sinuses},
  url          = {http://dx.doi.org/10.1364/OE.17.010849},
  volume       = {17},
  year         = {2009},
}