Advanced

Hepatic inflow occlusion increases the efficacy of interstitial laser-induced thermotherapy in rat

Sturesson, C; Liu, D. L; Stenram, U and Andersson-Engels, Stefan LU (1997) In Journal of Surgical Research 71(1). p.67-72
Abstract
Interstitial laser-induced thermotherapy (ILT) destroys tumors thermally, ILT was performed for treatment of liver tumors in rats to investigate the effect of hepatic inflow occlusion on temperature distribution and lesion size. Tumors were irradiated for 20 min with near-infrared light from a neodymium:yttrium-aluminum-garnet (Nd:YAG) laser, The laser light at a power of 1.5 W was delivered through a plane-cut optical fiber, the tip of which was placed in the tumor. Rats in group I received ILT without interruption of hepatic blood flow. Those in group II received ILT during hepatic inflow occlusion. Liver temperatures were measured during treatment. After 3 days the animals were sacrificed and the size of the lesions was measured.... (More)
Interstitial laser-induced thermotherapy (ILT) destroys tumors thermally, ILT was performed for treatment of liver tumors in rats to investigate the effect of hepatic inflow occlusion on temperature distribution and lesion size. Tumors were irradiated for 20 min with near-infrared light from a neodymium:yttrium-aluminum-garnet (Nd:YAG) laser, The laser light at a power of 1.5 W was delivered through a plane-cut optical fiber, the tip of which was placed in the tumor. Rats in group I received ILT without interruption of hepatic blood flow. Those in group II received ILT during hepatic inflow occlusion. Liver temperatures were measured during treatment. After 3 days the animals were sacrificed and the size of the lesions was measured. Occlusion of the hepatic inflow during ILT increased the maximum lesion diameter, as measured at the liver surface, by 47%. Linear interpolation between the temperatures measured at 6 and 12 mm distance from the fiber tip revealed that the temperature at the necrotic border just before the end of treatment was approximately 45 degrees C in both the occluded and nonoccluded groups, indicating that the hepatic inflow occlusion caused no increase in tissue thermal sensitivity, This study shows that occlusion of the hepatic in-flow during interstitial laser-induced thermotherapy causes a significant increase in lesion size, which could have implications for the treatment of hepatic tumors. (C) 1997 Academic Press. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Surgical Research
volume
71
issue
1
pages
67 - 72
publisher
Elsevier
external identifiers
  • Scopus:0031571141
ISSN
1095-8673
DOI
10.1006/jsre.1997.5121
language
English
LU publication?
yes
id
2068e1fe-9f8b-4cde-96da-5068b04731b1 (old id 2259450)
date added to LUP
2012-02-09 21:32:31
date last changed
2016-11-20 04:23:01
@misc{2068e1fe-9f8b-4cde-96da-5068b04731b1,
  abstract     = {Interstitial laser-induced thermotherapy (ILT) destroys tumors thermally, ILT was performed for treatment of liver tumors in rats to investigate the effect of hepatic inflow occlusion on temperature distribution and lesion size. Tumors were irradiated for 20 min with near-infrared light from a neodymium:yttrium-aluminum-garnet (Nd:YAG) laser, The laser light at a power of 1.5 W was delivered through a plane-cut optical fiber, the tip of which was placed in the tumor. Rats in group I received ILT without interruption of hepatic blood flow. Those in group II received ILT during hepatic inflow occlusion. Liver temperatures were measured during treatment. After 3 days the animals were sacrificed and the size of the lesions was measured. Occlusion of the hepatic inflow during ILT increased the maximum lesion diameter, as measured at the liver surface, by 47%. Linear interpolation between the temperatures measured at 6 and 12 mm distance from the fiber tip revealed that the temperature at the necrotic border just before the end of treatment was approximately 45 degrees C in both the occluded and nonoccluded groups, indicating that the hepatic inflow occlusion caused no increase in tissue thermal sensitivity, This study shows that occlusion of the hepatic in-flow during interstitial laser-induced thermotherapy causes a significant increase in lesion size, which could have implications for the treatment of hepatic tumors. (C) 1997 Academic Press.},
  author       = {Sturesson, C and Liu, D. L and Stenram, U and Andersson-Engels, Stefan},
  issn         = {1095-8673},
  language     = {eng},
  number       = {1},
  pages        = {67--72},
  publisher    = {ARRAY(0xa20e390)},
  series       = {Journal of Surgical Research},
  title        = {Hepatic inflow occlusion increases the efficacy of interstitial laser-induced thermotherapy in rat},
  url          = {http://dx.doi.org/10.1006/jsre.1997.5121},
  volume       = {71},
  year         = {1997},
}