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Elemental biological imaging by differential absorption with a laser-produced x-ray source

Tillman, C; Mercer, I; Svanberg, Sune LU and Herrlin, K (1996) In Journal of the Optical Society of America B - Optical Physics 13(1). p.209-215
Abstract
We demonstrate the novel application of hard x rays emitted by a laser-produced plasma for differential imaging of elements. An x-ray-emitting laser-produced plasma, obtained by the focusing of radiation from a 10-Hz terawatt laser, is used for biological imaging. The x-ray source can be arranged to yield characteristic x-ray emission lines with photon energies that bridge the K absorption edge of a chosen atomic species. One can obtain element-specific radiographs by recording transillumination images for different target materials on digital image plates and by subsequently subtracting or dividing the images. Successful phantom and experimental animal imaging are performed utilizing tantalum and gadolinium as target materials for the... (More)
We demonstrate the novel application of hard x rays emitted by a laser-produced plasma for differential imaging of elements. An x-ray-emitting laser-produced plasma, obtained by the focusing of radiation from a 10-Hz terawatt laser, is used for biological imaging. The x-ray source can be arranged to yield characteristic x-ray emission lines with photon energies that bridge the K absorption edge of a chosen atomic species. One can obtain element-specific radiographs by recording transillumination images for different target materials on digital image plates and by subsequently subtracting or dividing the images. Successful phantom and experimental animal imaging are performed utilizing tantalum and gadolinium as target materials for the terawatt laser and gadolinium as the imaged contrast agent. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of the Optical Society of America B - Optical Physics
volume
13
issue
1
pages
209 - 215
publisher
OSA
external identifiers
  • Scopus:0030532382
DOI
10.1364/JOSAB.13.000209
language
English
LU publication?
yes
id
eba4cc78-9d2a-453b-968d-d794417ace56 (old id 2259609)
date added to LUP
2012-02-07 00:33:36
date last changed
2016-04-16 08:26:26
@misc{eba4cc78-9d2a-453b-968d-d794417ace56,
  abstract     = {We demonstrate the novel application of hard x rays emitted by a laser-produced plasma for differential imaging of elements. An x-ray-emitting laser-produced plasma, obtained by the focusing of radiation from a 10-Hz terawatt laser, is used for biological imaging. The x-ray source can be arranged to yield characteristic x-ray emission lines with photon energies that bridge the K absorption edge of a chosen atomic species. One can obtain element-specific radiographs by recording transillumination images for different target materials on digital image plates and by subsequently subtracting or dividing the images. Successful phantom and experimental animal imaging are performed utilizing tantalum and gadolinium as target materials for the terawatt laser and gadolinium as the imaged contrast agent.},
  author       = {Tillman, C and Mercer, I and Svanberg, Sune and Herrlin, K},
  language     = {eng},
  number       = {1},
  pages        = {209--215},
  publisher    = {ARRAY(0x963c1c8)},
  series       = {Journal of the Optical Society of America B - Optical Physics},
  title        = {Elemental biological imaging by differential absorption with a laser-produced x-ray source},
  url          = {http://dx.doi.org/10.1364/JOSAB.13.000209},
  volume       = {13},
  year         = {1996},
}