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Evaluation of a Fiber-Optic Based Pulsed Laser System for Fluorescence Spectroscopy

Haj-Hosseini, N; Andersson-Engels, Stefan LU and Wardell, K (2008) 14th Nordic-Baltic Conference an Biomedical Engineering and Medical Physics, Riga, LATVIA, JUN 16-20, 2008 In 14TH NORDIC-BALTIC CONFERENCE ON BIOMEDICAL ENGINEERING AND MEDICAL PHYSICS 20. p.363-366
Abstract
A fiber optic based continous wave laser setup has been developed to record the 5-aminolevulinic (5-ALA) induced Protoporfyrin IX (PpIX) fluorescence signals from cerebral gliomas. To reduce the energy delivered to the tissue as well as suppression of the ambient lamp artifact from the recorded spectra, a pulsed laser setup has been developed and evaluated. This setup has been calibrated and first evaluations were performed on the 5-ALA treated skin showing PpIX fluorescence peaks from the ALA treated skin at 635 and 704 nm wavelengths. The system controls laser pulses through a computer interface and labview software package. Pulses as short as 50 ms over a period time of 500 ms are generated and optimally detected. The results from... (More)
A fiber optic based continous wave laser setup has been developed to record the 5-aminolevulinic (5-ALA) induced Protoporfyrin IX (PpIX) fluorescence signals from cerebral gliomas. To reduce the energy delivered to the tissue as well as suppression of the ambient lamp artifact from the recorded spectra, a pulsed laser setup has been developed and evaluated. This setup has been calibrated and first evaluations were performed on the 5-ALA treated skin showing PpIX fluorescence peaks from the ALA treated skin at 635 and 704 nm wavelengths. The system controls laser pulses through a computer interface and labview software package. Pulses as short as 50 ms over a period time of 500 ms are generated and optimally detected. The results from primary measurements on skin show an effective suppression of room fluorescent lamp artifact from the recorded spectra. (Less)
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author
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
in
14TH NORDIC-BALTIC CONFERENCE ON BIOMEDICAL ENGINEERING AND MEDICAL PHYSICS
editor
Katashev, A; Dekhtyar, Y and Spigulis, J
volume
20
pages
363 - 366
conference name
14th Nordic-Baltic Conference an Biomedical Engineering and Medical Physics, Riga, LATVIA, JUN 16-20, 2008
external identifiers
  • Scopus:78049444201
ISSN
1680-0737
ISBN
978-3-540-69366-6
DOI
10.1007/978-3-540-69367-3_97
language
English
LU publication?
yes
id
c090bd20-22e2-4332-a0a7-d3cc7d0c722f (old id 2260281)
date added to LUP
2012-01-26 23:34:58
date last changed
2016-10-13 04:23:21
@misc{c090bd20-22e2-4332-a0a7-d3cc7d0c722f,
  abstract     = {A fiber optic based continous wave laser setup has been developed to record the 5-aminolevulinic (5-ALA) induced Protoporfyrin IX (PpIX) fluorescence signals from cerebral gliomas. To reduce the energy delivered to the tissue as well as suppression of the ambient lamp artifact from the recorded spectra, a pulsed laser setup has been developed and evaluated. This setup has been calibrated and first evaluations were performed on the 5-ALA treated skin showing PpIX fluorescence peaks from the ALA treated skin at 635 and 704 nm wavelengths. The system controls laser pulses through a computer interface and labview software package. Pulses as short as 50 ms over a period time of 500 ms are generated and optimally detected. The results from primary measurements on skin show an effective suppression of room fluorescent lamp artifact from the recorded spectra.},
  author       = {Haj-Hosseini, N and Andersson-Engels, Stefan and Wardell, K},
  editor       = {Katashev, A and Dekhtyar, Y and Spigulis, J},
  isbn         = {978-3-540-69366-6},
  issn         = {1680-0737},
  language     = {eng},
  pages        = {363--366},
  series       = {14TH NORDIC-BALTIC CONFERENCE ON BIOMEDICAL ENGINEERING AND MEDICAL PHYSICS},
  title        = {Evaluation of a Fiber-Optic Based Pulsed Laser System for Fluorescence Spectroscopy},
  url          = {http://dx.doi.org/10.1007/978-3-540-69367-3_97},
  volume       = {20},
  year         = {2008},
}