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A Role for TLRs in Moraxella-superantigen induced polyclonal B cell activation.

Singh, Kalpana; Bayrak, Burcu LU and Riesbeck, Kristian LU (2012) In Frontiers in bioscience (Scholar edition) 4. p.1031-1043
Abstract
A number of microorganisms are capable of binding immunoglobulins (Igs) in a manner, which excludes binding to conventional antigen binding sites. Interaction of such bacterial proteins with surface immunoglobulins leads to polyclonal activation of B-lymphocytes. A recent example is Moraxella catarrhalis that binds to B lymphocytes in an IgD-dependent manner and induces proliferation and differentiation of B lymphocytes leading to the production of unspecific Igs. The activation is mediated by Moraxella IgD binding protein (MID), which specifically binds to both soluble IgD and the IgD B cell receptor (BCR). Besides cross-linking the BCR, whole Moraxella and outer membrane vesicles (OMVs) engage Toll like receptors (TLRs) to further... (More)
A number of microorganisms are capable of binding immunoglobulins (Igs) in a manner, which excludes binding to conventional antigen binding sites. Interaction of such bacterial proteins with surface immunoglobulins leads to polyclonal activation of B-lymphocytes. A recent example is Moraxella catarrhalis that binds to B lymphocytes in an IgD-dependent manner and induces proliferation and differentiation of B lymphocytes leading to the production of unspecific Igs. The activation is mediated by Moraxella IgD binding protein (MID), which specifically binds to both soluble IgD and the IgD B cell receptor (BCR). Besides cross-linking the BCR, whole Moraxella and outer membrane vesicles (OMVs) engage Toll like receptors (TLRs) to further increase the response. TLR activation leads to initiation of signaling pathways, which evoke a proinflammatory response against the invading microbes. Polyclonal B cell activation has in general been implicated in various phenomenons that are detrimental for the host but beneficial for pathogens, for example, autoimmune manifestations and redirection of the immune system. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Frontiers in bioscience (Scholar edition)
volume
4
pages
1031 - 1043
publisher
Frontiers in Bioscience
external identifiers
  • PMID:22202107
  • Scopus:84869387874
ISSN
1945-0524
language
English
LU publication?
yes
id
25b3d170-5817-4d0f-b9ed-c1521d3a56f6 (old id 2273500)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/22202107?dopt=Abstract
date added to LUP
2012-01-03 16:07:41
date last changed
2016-10-13 04:35:08
@misc{25b3d170-5817-4d0f-b9ed-c1521d3a56f6,
  abstract     = {A number of microorganisms are capable of binding immunoglobulins (Igs) in a manner, which excludes binding to conventional antigen binding sites. Interaction of such bacterial proteins with surface immunoglobulins leads to polyclonal activation of B-lymphocytes. A recent example is Moraxella catarrhalis that binds to B lymphocytes in an IgD-dependent manner and induces proliferation and differentiation of B lymphocytes leading to the production of unspecific Igs. The activation is mediated by Moraxella IgD binding protein (MID), which specifically binds to both soluble IgD and the IgD B cell receptor (BCR). Besides cross-linking the BCR, whole Moraxella and outer membrane vesicles (OMVs) engage Toll like receptors (TLRs) to further increase the response. TLR activation leads to initiation of signaling pathways, which evoke a proinflammatory response against the invading microbes. Polyclonal B cell activation has in general been implicated in various phenomenons that are detrimental for the host but beneficial for pathogens, for example, autoimmune manifestations and redirection of the immune system.},
  author       = {Singh, Kalpana and Bayrak, Burcu and Riesbeck, Kristian},
  issn         = {1945-0524},
  language     = {eng},
  pages        = {1031--1043},
  publisher    = {ARRAY(0x75de910)},
  series       = {Frontiers in bioscience (Scholar edition)},
  title        = {A Role for TLRs in Moraxella-superantigen induced polyclonal B cell activation.},
  volume       = {4},
  year         = {2012},
}