Advanced

A multicentre study on the reliability of qualitative and quantitative nail-fold videocapillaroscopy assessment.

Hofstee, Herman M A; Serné, Erik H; Roberts, Christopher; Hesselstrand, Roger LU ; Scheja, Agneta LU ; Moore, Tonia L; Wildt, Marie LU ; Manning, Joanne B; Vonk Noordegraaf, Anton and Voskuyl, Alexandre E, et al. (2012) In Rheumatology (Oxford, England) 51(4). p.749-755
Abstract
Objective. To investigate the inter- and intra-observer reliability of both qualitative and quantitative parameters used in the assessment of nail-fold capillaroscopy images.Methods. Fifty mosaic nail-fold images of healthy controls (n = 10), patients with primary RP (n = 10) and SSc (n = 30) were assessed in random order by two blinded observers on two occasions at centres in Sweden, UK and The Netherlands. Each image was therefore scored by six observers twice.Results. Inter- and intra-observer reliability of quantitative parameters showed substantial to almost perfect agreement [inter- and intra-observer weighted κ's for the number of widened capillaries was 0.75 and 0.87 and giant capillaries was 0.84 and 0.92, intra-class correlation... (More)
Objective. To investigate the inter- and intra-observer reliability of both qualitative and quantitative parameters used in the assessment of nail-fold capillaroscopy images.Methods. Fifty mosaic nail-fold images of healthy controls (n = 10), patients with primary RP (n = 10) and SSc (n = 30) were assessed in random order by two blinded observers on two occasions at centres in Sweden, UK and The Netherlands. Each image was therefore scored by six observers twice.Results. Inter- and intra-observer reliability of quantitative parameters showed substantial to almost perfect agreement [inter- and intra-observer weighted κ's for the number of widened capillaries was 0.75 and 0.87 and giant capillaries was 0.84 and 0.92, intra-class correlation coefficients (ICCs) for capillary density was 0.87 and 0.92 and total loop width was 0.94 and 0.98, respectively]. Qualitative parameters including architecture, avascularity, haemorrhage, crossed, ramified and bushy capillaries showed moderate to substantial inter-observer reproducibility (weighted κ ranging from 0.47 to 0.73), and substantial intra-observer repeatability (weighted κ ranging from 0.71 to 0.80), whereas the scoring of tortuous and bizarre capillaries showed poor inter-observer and substantial intra-observer agreement (inter-observer weighted κ's was 0.39 and 0.21 and intra-observer weighted κ's was 0.68 and 0.76, respectively).Conclusion. All quantitative and certain qualitative parameters are highly reliable in terms of inter- and intra-observer agreement. A combination of parameters with the highest reliability should be incorporated into future capillaroscopic scoring systems in studies of prediction and monitoring of SSc spectrum disorders. (Less)
Please use this url to cite or link to this publication:
author
, et al. (More)
(Less)
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Rheumatology (Oxford, England)
volume
51
issue
4
pages
749 - 755
publisher
Oxford University Press
external identifiers
  • WOS:000302017200024
  • PMID:22190689
  • Scopus:84858678453
ISSN
1462-0332
DOI
10.1093/rheumatology/ker403
language
English
LU publication?
yes
id
22b3730e-be91-4b49-8cc2-ba93617ab478 (old id 2273683)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/22190689?dopt=Abstract
date added to LUP
2012-01-03 22:18:11
date last changed
2016-10-13 15:12:34
@misc{22b3730e-be91-4b49-8cc2-ba93617ab478,
  abstract     = {Objective. To investigate the inter- and intra-observer reliability of both qualitative and quantitative parameters used in the assessment of nail-fold capillaroscopy images.Methods. Fifty mosaic nail-fold images of healthy controls (n = 10), patients with primary RP (n = 10) and SSc (n = 30) were assessed in random order by two blinded observers on two occasions at centres in Sweden, UK and The Netherlands. Each image was therefore scored by six observers twice.Results. Inter- and intra-observer reliability of quantitative parameters showed substantial to almost perfect agreement [inter- and intra-observer weighted κ's for the number of widened capillaries was 0.75 and 0.87 and giant capillaries was 0.84 and 0.92, intra-class correlation coefficients (ICCs) for capillary density was 0.87 and 0.92 and total loop width was 0.94 and 0.98, respectively]. Qualitative parameters including architecture, avascularity, haemorrhage, crossed, ramified and bushy capillaries showed moderate to substantial inter-observer reproducibility (weighted κ ranging from 0.47 to 0.73), and substantial intra-observer repeatability (weighted κ ranging from 0.71 to 0.80), whereas the scoring of tortuous and bizarre capillaries showed poor inter-observer and substantial intra-observer agreement (inter-observer weighted κ's was 0.39 and 0.21 and intra-observer weighted κ's was 0.68 and 0.76, respectively).Conclusion. All quantitative and certain qualitative parameters are highly reliable in terms of inter- and intra-observer agreement. A combination of parameters with the highest reliability should be incorporated into future capillaroscopic scoring systems in studies of prediction and monitoring of SSc spectrum disorders.},
  author       = {Hofstee, Herman M A and Serné, Erik H and Roberts, Christopher and Hesselstrand, Roger and Scheja, Agneta and Moore, Tonia L and Wildt, Marie and Manning, Joanne B and Vonk Noordegraaf, Anton and Voskuyl, Alexandre E and Herrick, Ariane L},
  issn         = {1462-0332},
  language     = {eng},
  number       = {4},
  pages        = {749--755},
  publisher    = {ARRAY(0x5c5cef8)},
  series       = {Rheumatology (Oxford, England)},
  title        = {A multicentre study on the reliability of qualitative and quantitative nail-fold videocapillaroscopy assessment.},
  url          = {http://dx.doi.org/10.1093/rheumatology/ker403},
  volume       = {51},
  year         = {2012},
}