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Effects of hemodialysis and longterm erythropoietin treatment on protein C, and on free and total protein S

Clyne, Naomi LU ; Egberg, Nils and Lins, Lars Eric (1995) In Thrombosis Research 80(2). p.161-168
Abstract

We studied 37 hemodialysis patients during hemodialysis in order to assess the effects of dialysis on endogenous plasma coagulation inhibitors (antithrombin III, protein C, free and total protein S). The patients were examined prior to erythropoietin (EPO) treatment, upon reaching target hemoglobin (Hb) and after 3 months at steady state Hb levels. The levels of protein C increased significantly during dialysis. However, EPO treatment did not affect the levels of any of the endogenous coagulation inhibitors, either upon reaching target Hb or after 3 months of steady state Hb. The sequence of change during dialysis for protein C, free and total protein S was constant when comparing respective patterns prior to EPO treatment to those at... (More)

We studied 37 hemodialysis patients during hemodialysis in order to assess the effects of dialysis on endogenous plasma coagulation inhibitors (antithrombin III, protein C, free and total protein S). The patients were examined prior to erythropoietin (EPO) treatment, upon reaching target hemoglobin (Hb) and after 3 months at steady state Hb levels. The levels of protein C increased significantly during dialysis. However, EPO treatment did not affect the levels of any of the endogenous coagulation inhibitors, either upon reaching target Hb or after 3 months of steady state Hb. The sequence of change during dialysis for protein C, free and total protein S was constant when comparing respective patterns prior to EPO treatment to those at target Hb and steady state Hb respectively. In conclusion, hemodialysis seems to activate synthesis of endogenous coagulation while partial correction of anaemia with EPO does not affect the levels of these inhibitors. © 1995.

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author
publishing date
type
Contribution to journal
publication status
published
keywords
coagulation, erythropoietin, hemodialysis, protein C, protein S
in
Thrombosis Research
volume
80
issue
2
pages
8 pages
publisher
Elsevier
external identifiers
  • Scopus:0028973122
ISSN
0049-3848
DOI
10.1016/0049-3848(95)00162-K
language
English
LU publication?
no
id
2322fb9c-4639-48e0-84cc-ba338ce140dd
date added to LUP
2016-08-30 22:02:45
date last changed
2016-09-16 15:09:51
@misc{2322fb9c-4639-48e0-84cc-ba338ce140dd,
  abstract     = {<p>We studied 37 hemodialysis patients during hemodialysis in order to assess the effects of dialysis on endogenous plasma coagulation inhibitors (antithrombin III, protein C, free and total protein S). The patients were examined prior to erythropoietin (EPO) treatment, upon reaching target hemoglobin (Hb) and after 3 months at steady state Hb levels. The levels of protein C increased significantly during dialysis. However, EPO treatment did not affect the levels of any of the endogenous coagulation inhibitors, either upon reaching target Hb or after 3 months of steady state Hb. The sequence of change during dialysis for protein C, free and total protein S was constant when comparing respective patterns prior to EPO treatment to those at target Hb and steady state Hb respectively. In conclusion, hemodialysis seems to activate synthesis of endogenous coagulation while partial correction of anaemia with EPO does not affect the levels of these inhibitors. © 1995.</p>},
  author       = {Clyne, Naomi and Egberg, Nils and Lins, Lars Eric},
  issn         = {0049-3848},
  keyword      = {coagulation,erythropoietin,hemodialysis,protein C,protein S},
  language     = {eng},
  month        = {10},
  number       = {2},
  pages        = {161--168},
  publisher    = {ARRAY(0xb13d098)},
  series       = {Thrombosis Research},
  title        = {Effects of hemodialysis and longterm erythropoietin treatment on protein C, and on free and total protein S},
  url          = {http://dx.doi.org/10.1016/0049-3848(95)00162-K},
  volume       = {80},
  year         = {1995},
}