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A clinically confirmed family history for early myocardial infarction is associated with increased risk of obesity, insulin resistance and metabolic syndrome.

Magnusson, Martin LU ; Burri, Philippe LU and Melander, Olle LU (2012) In Journal of Hypertension 30(5). p.948-953
Abstract
OBJECTIVE:: The risk factor pattern underlying a parental history of myocardial infarction (MI) is incompletely understood. We examined whether a parental history of clinically verified early MI may promote development of insulin resistance, obesity and the metabolic syndrome (MetS).



METHODS:: One hundred and seventy-four offspring to patients with clinically verified MI before 60 years of age in the population-based prospective Malmo Diet and Cancer (MDC) study were recruited (positive parental history). As controls, we included 174 offspring of MDC participants without MI during 14 years of follow-up in the MDC (negative parental history). MetS was defined according to the National Cholesterol Education Program Adult... (More)
OBJECTIVE:: The risk factor pattern underlying a parental history of myocardial infarction (MI) is incompletely understood. We examined whether a parental history of clinically verified early MI may promote development of insulin resistance, obesity and the metabolic syndrome (MetS).



METHODS:: One hundred and seventy-four offspring to patients with clinically verified MI before 60 years of age in the population-based prospective Malmo Diet and Cancer (MDC) study were recruited (positive parental history). As controls, we included 174 offspring of MDC participants without MI during 14 years of follow-up in the MDC (negative parental history). MetS was defined according to the National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III) guidelines, obesity as BMI greater than 30 kg/m and insulin resistance as the top quartile of homeostasis model assessment index in the 348 included offspring (mean age 44 years, 49% women).



RESULTS:: The odds ratio, 95% confidence interval, for MetS in positive parental history as compared with negative parental history was 2.05, 1.06-4.00 (P = 0.034) after adjustment for age, sex, low-density lipoprotein cholesterol (LDL) and smoking. positive parental history was also independently associated with obesity 2.50, 1.34-4.66 (P = 0.003), abdominal obesity 2.01, 1.21-3.33 (P = 0.007) and insulin resistance 1.97, 1.14-3.40 (P = 0.014), whereas there was no association with LDL and smoking. All of these relationships were stronger in men than in women.



CONCLUSION:: Parental history of clinically verified early MI is associated with MetS, obesity and insulin resistance rather than with traditional cardiovascular disease risk factors such as LDL and smoking, suggesting that primary preventive interventions targeted at weight reduction and improvement of insulin sensitivity may be particularly beneficial in this subset of the population. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Hypertension
volume
30
issue
5
pages
948 - 953
publisher
Lippincott Williams & Wilkins
external identifiers
  • WOS:000302819500019
  • PMID:22343538
  • Scopus:84859886351
ISSN
1473-5598
DOI
10.1097/HJH.0b013e328351c285
language
English
LU publication?
yes
id
ba6bfbb0-90e5-43a6-a8d8-b03f1abd9cc4 (old id 2366761)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/22343538?dopt=Abstract
date added to LUP
2012-03-02 12:25:45
date last changed
2016-10-13 04:36:35
@misc{ba6bfbb0-90e5-43a6-a8d8-b03f1abd9cc4,
  abstract     = {OBJECTIVE:: The risk factor pattern underlying a parental history of myocardial infarction (MI) is incompletely understood. We examined whether a parental history of clinically verified early MI may promote development of insulin resistance, obesity and the metabolic syndrome (MetS). <br/><br>
<br/><br>
METHODS:: One hundred and seventy-four offspring to patients with clinically verified MI before 60 years of age in the population-based prospective Malmo Diet and Cancer (MDC) study were recruited (positive parental history). As controls, we included 174 offspring of MDC participants without MI during 14 years of follow-up in the MDC (negative parental history). MetS was defined according to the National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III) guidelines, obesity as BMI greater than 30 kg/m and insulin resistance as the top quartile of homeostasis model assessment index in the 348 included offspring (mean age 44 years, 49% women). <br/><br>
<br/><br>
RESULTS:: The odds ratio, 95% confidence interval, for MetS in positive parental history as compared with negative parental history was 2.05, 1.06-4.00 (P = 0.034) after adjustment for age, sex, low-density lipoprotein cholesterol (LDL) and smoking. positive parental history was also independently associated with obesity 2.50, 1.34-4.66 (P = 0.003), abdominal obesity 2.01, 1.21-3.33 (P = 0.007) and insulin resistance 1.97, 1.14-3.40 (P = 0.014), whereas there was no association with LDL and smoking. All of these relationships were stronger in men than in women. <br/><br>
<br/><br>
CONCLUSION:: Parental history of clinically verified early MI is associated with MetS, obesity and insulin resistance rather than with traditional cardiovascular disease risk factors such as LDL and smoking, suggesting that primary preventive interventions targeted at weight reduction and improvement of insulin sensitivity may be particularly beneficial in this subset of the population.},
  author       = {Magnusson, Martin and Burri, Philippe and Melander, Olle},
  issn         = {1473-5598},
  language     = {eng},
  number       = {5},
  pages        = {948--953},
  publisher    = {ARRAY(0xb2cf7a0)},
  series       = {Journal of Hypertension},
  title        = {A clinically confirmed family history for early myocardial infarction is associated with increased risk of obesity, insulin resistance and metabolic syndrome.},
  url          = {http://dx.doi.org/10.1097/HJH.0b013e328351c285},
  volume       = {30},
  year         = {2012},
}