Analysis of ten candidate genes in autism by association and linkage
(2002) In American Journal of Medical Genetics 114(2). p.125-128- Abstract
- We studied the possible involvement of ten candidate genes in autism: proenkephalin, prodynorphin, and proprotein convertase subtilisin/kexin type 2 (opioid metabolism); tyrosine hydroxylase, dopamine receptors D2 and D5, monoamine oxidases A and B (monoaminergic system); brain-derived neurotrophic factor, and neural cell adhesion molecule (involved in neurodevelopment). Thirty-eight families with two affected siblings and one family with two affected half-siblings, recruited by the Paris Autism Research International Sibpair Study (PARIS), were tested using the transmission disequilibrium test and two-point affected sib-pair linkage analysis. We found no evidence for association or linkage with intragenic or linked markers. Our family... (More)
- We studied the possible involvement of ten candidate genes in autism: proenkephalin, prodynorphin, and proprotein convertase subtilisin/kexin type 2 (opioid metabolism); tyrosine hydroxylase, dopamine receptors D2 and D5, monoamine oxidases A and B (monoaminergic system); brain-derived neurotrophic factor, and neural cell adhesion molecule (involved in neurodevelopment). Thirty-eight families with two affected siblings and one family with two affected half-siblings, recruited by the Paris Autism Research International Sibpair Study (PARIS), were tested using the transmission disequilibrium test and two-point affected sib-pair linkage analysis. We found no evidence for association or linkage with intragenic or linked markers. Our family sample has good power for detecting a linkage disequilibrium of 0.80. Thus, these genes are unlikely to play a major role in the families studied, but further studies in a much larger sample would be needed to highlight weaker genetic effects. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/2372783
- author
- publishing date
- 2002
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- autism, linkage disequilibrium, linkage, sib-pair
- in
- American Journal of Medical Genetics
- volume
- 114
- issue
- 2
- pages
- 125 - 128
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- scopus:3042746413
- ISSN
- 0148-7299
- DOI
- 10.1002/ajmg.10041
- language
- English
- LU publication?
- no
- id
- d55ee681-7815-4656-a4ab-247572c8835d (old id 2372783)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/11857571
- http://onlinelibrary.wiley.com/doi/10.1002/ajmg.10041/abstract?systemMessage=Wiley+Online+Library+will+be+disrupted+on+11+May+from+10%3A00-12%3A00+BST+(05%3A00-07%3A00+EDT)+for+essential+maintenance
- date added to LUP
- 2016-04-04 11:06:46
- date last changed
- 2022-01-29 21:20:13
@article{d55ee681-7815-4656-a4ab-247572c8835d, abstract = {{We studied the possible involvement of ten candidate genes in autism: proenkephalin, prodynorphin, and proprotein convertase subtilisin/kexin type 2 (opioid metabolism); tyrosine hydroxylase, dopamine receptors D2 and D5, monoamine oxidases A and B (monoaminergic system); brain-derived neurotrophic factor, and neural cell adhesion molecule (involved in neurodevelopment). Thirty-eight families with two affected siblings and one family with two affected half-siblings, recruited by the Paris Autism Research International Sibpair Study (PARIS), were tested using the transmission disequilibrium test and two-point affected sib-pair linkage analysis. We found no evidence for association or linkage with intragenic or linked markers. Our family sample has good power for detecting a linkage disequilibrium of 0.80. Thus, these genes are unlikely to play a major role in the families studied, but further studies in a much larger sample would be needed to highlight weaker genetic effects.}}, author = {{Philippe, Anne and Guilloud-Bataille, Michel and Martinez, Maria and Gillberg, Christopher and Råstam, Maria and Sponheim, Eili and Coleman, Mary and Zappella, Michele and Aschauer, Harald and Penet, Christiane and Feingold, Josué and Brice, Alexis and Leboyer, Marion}}, issn = {{0148-7299}}, keywords = {{autism; linkage disequilibrium; linkage; sib-pair}}, language = {{eng}}, number = {{2}}, pages = {{125--128}}, publisher = {{John Wiley & Sons Inc.}}, series = {{American Journal of Medical Genetics}}, title = {{Analysis of ten candidate genes in autism by association and linkage}}, url = {{http://dx.doi.org/10.1002/ajmg.10041}}, doi = {{10.1002/ajmg.10041}}, volume = {{114}}, year = {{2002}}, }