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Neocartilage after artificial cartilage repair in the rabbit : Histology and proteoglycan fragments in joint fluid

Messner, K.; Lohmander, L. S. LU and Gillquist, J. (1993) In Journal of Biomedical Materials Research 27(7). p.949-954
Abstract

Repair of full-thickness cartilage defects of the rabbit medial femoral condyle with artificial plugs and periosteal grafts was followed for 1 year. The morphological characteristics of the neocartilage after repair and the concentration of proteoglycan fragments in the joint fluid (CPFF) were evaluated. The CPFF showed only a weak correlation to the histological score of the neocartilage. Normal cartilage and subchondral bone did not develop with any of the repair alternatives. With a Dacron plug, neocartilage formation appeared earlier than with natural repair and was better than with periosteal grafting. We conclude that Dacron plugs could serve as a scaffold for neocartilage formation. The CPFF reflected surgical trauma and late... (More)

Repair of full-thickness cartilage defects of the rabbit medial femoral condyle with artificial plugs and periosteal grafts was followed for 1 year. The morphological characteristics of the neocartilage after repair and the concentration of proteoglycan fragments in the joint fluid (CPFF) were evaluated. The CPFF showed only a weak correlation to the histological score of the neocartilage. Normal cartilage and subchondral bone did not develop with any of the repair alternatives. With a Dacron plug, neocartilage formation appeared earlier than with natural repair and was better than with periosteal grafting. We conclude that Dacron plugs could serve as a scaffold for neocartilage formation. The CPFF reflected surgical trauma and late degeneration of neocartilage but did not indicate minor differences in quality between cartilage repair techniques, probably because of the limited size of the grafted defect.

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organization
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type
Contribution to journal
publication status
published
subject
in
Journal of Biomedical Materials Research
volume
27
issue
7
pages
6 pages
publisher
John Wiley & Sons
external identifiers
  • Scopus:0027627382
ISSN
0021-9304
language
English
LU publication?
yes
id
2844671f-986e-4492-b9ce-9bbeba5ba009
date added to LUP
2016-05-04 23:40:40
date last changed
2016-10-13 05:07:57
@misc{2844671f-986e-4492-b9ce-9bbeba5ba009,
  abstract     = {<p>Repair of full-thickness cartilage defects of the rabbit medial femoral condyle with artificial plugs and periosteal grafts was followed for 1 year. The morphological characteristics of the neocartilage after repair and the concentration of proteoglycan fragments in the joint fluid (CPFF) were evaluated. The CPFF showed only a weak correlation to the histological score of the neocartilage. Normal cartilage and subchondral bone did not develop with any of the repair alternatives. With a Dacron plug, neocartilage formation appeared earlier than with natural repair and was better than with periosteal grafting. We conclude that Dacron plugs could serve as a scaffold for neocartilage formation. The CPFF reflected surgical trauma and late degeneration of neocartilage but did not indicate minor differences in quality between cartilage repair techniques, probably because of the limited size of the grafted defect.</p>},
  author       = {Messner, K. and Lohmander, L. S. and Gillquist, J.},
  issn         = {0021-9304},
  language     = {eng},
  number       = {7},
  pages        = {949--954},
  publisher    = {ARRAY(0x83e1b80)},
  series       = {Journal of Biomedical Materials Research},
  title        = {Neocartilage after artificial cartilage repair in the rabbit : Histology and proteoglycan fragments in joint fluid},
  volume       = {27},
  year         = {1993},
}