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Blood biomarkers and measures of pulmonary function-A study from the Swedish twin registry.

Engström, Gunnar LU ; Lindberg, Claes; Gerhardsson de Verdier, Maria; Nihlén, Ulf LU ; Anderson, Martin; Svartengren, Magnus and Forsman-Semb, Kristina (2012) In Respiratory Medicine 106(9). p.1250-1257
Abstract
OBJECTIVE:

There is great need of biomarkers for research and clinical purposes in COPD. This study explored the relationships between ten putative plasma biomarkers of COPD and physiological measures of reduced lung function.



METHODS:

FEV(1), FVC, residual volume/total lung capacity (RV/TLC) and CO diffusion capacity (D(L)CO) were assessed in 357 subjects from the Swedish Twin Registry. The lung function measures were studied in relation to plasma levels of desmosines, C-reactive protein (CRP), plasminogen inhibitor activator (PAI-1) concentration and activity, tissue inhibitor of metalloproteinase (TIMP-1), clara cell protein 16 (CC16), surfactant protein D (SPD), matrix metalloproteinase 9... (More)
OBJECTIVE:

There is great need of biomarkers for research and clinical purposes in COPD. This study explored the relationships between ten putative plasma biomarkers of COPD and physiological measures of reduced lung function.



METHODS:

FEV(1), FVC, residual volume/total lung capacity (RV/TLC) and CO diffusion capacity (D(L)CO) were assessed in 357 subjects from the Swedish Twin Registry. The lung function measures were studied in relation to plasma levels of desmosines, C-reactive protein (CRP), plasminogen inhibitor activator (PAI-1) concentration and activity, tissue inhibitor of metalloproteinase (TIMP-1), clara cell protein 16 (CC16), surfactant protein D (SPD), matrix metalloproteinase 9 (MMP-9), hepatocyte growth factor (HGF) and interleukin (IL)-8.



RESULTS:

After adjustments for age, sex, height, BMI and smoking, FEV(1) was significantly associated with PAI-1 activity and desmosines. RV/TLC was significantly associated with CC16, PAI-1 concentration and PAI-1 activity, and D(L)CO was significantly associated with desmosines, TIMP-1 and CRP. When the multivariate analysis was restricted to subjects with COPD (i.e., FEV(1)/FVC < 0.70), CRP and desmosines were inversely associated with lung function.



CONCLUSION:

Several biomarkers were associated with lung function in this cross-sectional study. Especially CRP and desmosines could be useful markers to assess disease severity in subjects with COPD. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Respiratory Medicine
volume
106
issue
9
pages
1250 - 1257
publisher
Elsevier
external identifiers
  • WOS:000308768300006
  • PMID:22687639
  • Scopus:84864586574
ISSN
1532-3064
DOI
10.1016/j.rmed.2012.05.004
language
English
LU publication?
yes
id
5df245b3-1701-4da2-b4cc-cb0d12d7d693 (old id 2859546)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/22687639?dopt=Abstract
date added to LUP
2012-07-04 16:08:54
date last changed
2016-10-13 04:30:35
@misc{5df245b3-1701-4da2-b4cc-cb0d12d7d693,
  abstract     = {OBJECTIVE: <br/><br>
There is great need of biomarkers for research and clinical purposes in COPD. This study explored the relationships between ten putative plasma biomarkers of COPD and physiological measures of reduced lung function. <br/><br>
<br/><br>
METHODS: <br/><br>
FEV(1), FVC, residual volume/total lung capacity (RV/TLC) and CO diffusion capacity (D(L)CO) were assessed in 357 subjects from the Swedish Twin Registry. The lung function measures were studied in relation to plasma levels of desmosines, C-reactive protein (CRP), plasminogen inhibitor activator (PAI-1) concentration and activity, tissue inhibitor of metalloproteinase (TIMP-1), clara cell protein 16 (CC16), surfactant protein D (SPD), matrix metalloproteinase 9 (MMP-9), hepatocyte growth factor (HGF) and interleukin (IL)-8. <br/><br>
<br/><br>
RESULTS: <br/><br>
After adjustments for age, sex, height, BMI and smoking, FEV(1) was significantly associated with PAI-1 activity and desmosines. RV/TLC was significantly associated with CC16, PAI-1 concentration and PAI-1 activity, and D(L)CO was significantly associated with desmosines, TIMP-1 and CRP. When the multivariate analysis was restricted to subjects with COPD (i.e., FEV(1)/FVC &lt; 0.70), CRP and desmosines were inversely associated with lung function. <br/><br>
<br/><br>
CONCLUSION: <br/><br>
Several biomarkers were associated with lung function in this cross-sectional study. Especially CRP and desmosines could be useful markers to assess disease severity in subjects with COPD.},
  author       = {Engström, Gunnar and Lindberg, Claes and Gerhardsson de Verdier, Maria and Nihlén, Ulf and Anderson, Martin and Svartengren, Magnus and Forsman-Semb, Kristina},
  issn         = {1532-3064},
  language     = {eng},
  number       = {9},
  pages        = {1250--1257},
  publisher    = {ARRAY(0x7464730)},
  series       = {Respiratory Medicine},
  title        = {Blood biomarkers and measures of pulmonary function-A study from the Swedish twin registry.},
  url          = {http://dx.doi.org/10.1016/j.rmed.2012.05.004},
  volume       = {106},
  year         = {2012},
}