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Hypocalcaemia after total thyroidectomy for Graves' disease and for benign atoxic multinodular goitre.

Hallgrimsson, Palli LU ; Nordenström, Erik LU ; Bergenfelz, Anders LU and Almquist, Martin LU (2012) In Langenbeck's Archives of Surgery 397(7). p.1133-1137
Abstract
PURPOSE: Postoperative hypocalcaemia has been reported to be more common after total thyroidectomy (TT) for Graves' disease than after TT for benign atoxic multinodular goitre (MNG). The reasons for this potential association are not clear. In the present study, the frequency and risk factors of hypocalcaemia after TT for Graves' vs MNG were compared. METHODS: Between January 1999 and October 2009, patients with first-time surgery for Graves' disease or MNG treated with a TT were included in the study. Postoperative hypocalcaemia was defined by symptoms, calcium levels and treatment with calcium and/or vitamin D analogues during postoperative hospital stay, at discharge, and at the 6-week and 6-month follow-ups. Outcomes were compared with... (More)
PURPOSE: Postoperative hypocalcaemia has been reported to be more common after total thyroidectomy (TT) for Graves' disease than after TT for benign atoxic multinodular goitre (MNG). The reasons for this potential association are not clear. In the present study, the frequency and risk factors of hypocalcaemia after TT for Graves' vs MNG were compared. METHODS: Between January 1999 and October 2009, patients with first-time surgery for Graves' disease or MNG treated with a TT were included in the study. Postoperative hypocalcaemia was defined by symptoms, calcium levels and treatment with calcium and/or vitamin D analogues during postoperative hospital stay, at discharge, and at the 6-week and 6-month follow-ups. Outcomes were compared with Mann-Whitney, chi(2) and Fishers' exact test where appropriate and by multivariable logistic regression analysis. RESULTS: There were 128 patients with Graves' disease and 81 patients with MNG. Patients with Graves' disease were younger than patients with MNG (median age, 35 vs 51 years, p < 0.001). Symptoms of hypocalcaemia were more common in patients with Graves' disease (p < 0.001; OR, 95 % CI 3.26, 1.48-7.14), but the frequency of biochemical hypocalcaemia, postoperative levels of parathyroid hormone (PTH) and treatment with calcium and vitamin D did not differ between groups of patients. CONCLUSION: Apart from more frequent symptoms of hypocalcaemia in patients with Graves' disease, there was no difference in the overall frequency of biochemical hypocalcaemia, low levels of PTH and/or treatment with calcium and vitamin D. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Langenbeck's Archives of Surgery
volume
397
issue
7
pages
1133 - 1137
publisher
Springer
external identifiers
  • WOS:000310393000014
  • PMID:22976368
  • Scopus:84868194984
ISSN
1435-2451
DOI
10.1007/s00423-012-0981-1
language
English
LU publication?
yes
id
80226cef-32a8-435b-a0ca-d7c86502fe4b (old id 3123948)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/22976368?dopt=Abstract
date added to LUP
2012-10-03 21:39:57
date last changed
2016-10-27 16:10:49
@misc{80226cef-32a8-435b-a0ca-d7c86502fe4b,
  abstract     = {PURPOSE: Postoperative hypocalcaemia has been reported to be more common after total thyroidectomy (TT) for Graves' disease than after TT for benign atoxic multinodular goitre (MNG). The reasons for this potential association are not clear. In the present study, the frequency and risk factors of hypocalcaemia after TT for Graves' vs MNG were compared. METHODS: Between January 1999 and October 2009, patients with first-time surgery for Graves' disease or MNG treated with a TT were included in the study. Postoperative hypocalcaemia was defined by symptoms, calcium levels and treatment with calcium and/or vitamin D analogues during postoperative hospital stay, at discharge, and at the 6-week and 6-month follow-ups. Outcomes were compared with Mann-Whitney, chi(2) and Fishers' exact test where appropriate and by multivariable logistic regression analysis. RESULTS: There were 128 patients with Graves' disease and 81 patients with MNG. Patients with Graves' disease were younger than patients with MNG (median age, 35 vs 51 years, p &lt; 0.001). Symptoms of hypocalcaemia were more common in patients with Graves' disease (p &lt; 0.001; OR, 95 % CI 3.26, 1.48-7.14), but the frequency of biochemical hypocalcaemia, postoperative levels of parathyroid hormone (PTH) and treatment with calcium and vitamin D did not differ between groups of patients. CONCLUSION: Apart from more frequent symptoms of hypocalcaemia in patients with Graves' disease, there was no difference in the overall frequency of biochemical hypocalcaemia, low levels of PTH and/or treatment with calcium and vitamin D.},
  author       = {Hallgrimsson, Palli and Nordenström, Erik and Bergenfelz, Anders and Almquist, Martin},
  issn         = {1435-2451},
  language     = {eng},
  number       = {7},
  pages        = {1133--1137},
  publisher    = {ARRAY(0xaa05c90)},
  series       = {Langenbeck's Archives of Surgery},
  title        = {Hypocalcaemia after total thyroidectomy for Graves' disease and for benign atoxic multinodular goitre.},
  url          = {http://dx.doi.org/10.1007/s00423-012-0981-1},
  volume       = {397},
  year         = {2012},
}