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Cardiovascular risk factors and metabolic syndrome in people with established psychotic illnesses : baseline data from the IMPaCT randomized controlled trial

Gardner-Sood, P; Lally, J; Smith, S; Atakan, Z; Ismail, K; Greenwood, K E; Keen, A; O'Brien, C; Onagbesan, O and Fung, C, et al. (2015) In Psychological Medicine 45(12). p.29-2619
Abstract

BACKGROUND: The aims of the study were to determine the prevalence of cardiometabolic risk factors and establish the proportion of people with psychosis meeting criteria for the metabolic syndrome (MetS). The study also aimed to identify the key lifestyle behaviours associated with increased risk of the MetS and to investigate whether the MetS is associated with illness severity and degree of functional impairment.

METHOD: Baseline data were collected as part of a large randomized controlled trial (IMPaCT RCT). The study took place within community mental health teams in five Mental Health NHS Trusts in urban and rural locations across England. A total of 450 randomly selected out-patients, aged 18-65 years, with an established... (More)

BACKGROUND: The aims of the study were to determine the prevalence of cardiometabolic risk factors and establish the proportion of people with psychosis meeting criteria for the metabolic syndrome (MetS). The study also aimed to identify the key lifestyle behaviours associated with increased risk of the MetS and to investigate whether the MetS is associated with illness severity and degree of functional impairment.

METHOD: Baseline data were collected as part of a large randomized controlled trial (IMPaCT RCT). The study took place within community mental health teams in five Mental Health NHS Trusts in urban and rural locations across England. A total of 450 randomly selected out-patients, aged 18-65 years, with an established psychotic illness were recruited. We ascertained the prevalence rates of cardiometabolic risk factors, illness severity and functional impairment and calculated rates of the MetS, using International Diabetes Federation (IDF) and National Cholesterol Education Program Third Adult Treatment Panel criteria.

RESULTS: High rates of cardiometabolic risk factors were found. Nearly all women and most men had waist circumference exceeding the IDF threshold for central obesity. Half the sample was obese (body mass index ≥ 30 kg/m2) and a fifth met the criteria for type 2 diabetes mellitus. Females were more likely to be obese than males (61% v. 42%, p < 0.001). Of the 308 patients with complete laboratory measures, 57% (n = 175) met the IDF criteria for the MetS.

CONCLUSIONS: In the UK, the prevalence of cardiometabolic risk factors in individuals with psychotic illnesses is much higher than that observed in national general population studies as well as in most international studies of patients with psychosis.

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Adolescent, Adult, Aged, Benzodiazepines, Cardiovascular Diseases, Community Mental Health Centers, Diabetes Mellitus, Type 2, England, Female, Humans, Male, Mental Disorders, Metabolic Syndrome X, Middle Aged, Obesity, Prevalence, Risk Factors, Rural Population, Sex Distribution, State Medicine, Urban Population, Young Adult
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Psychological Medicine
volume
45
issue
12
pages
11 pages
publisher
Cambridge University Press
external identifiers
  • Scopus:84938579554
ISSN
1469-8978
DOI
10.1017/S0033291715000562
language
English
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yes
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326fd57c-a93f-4a6d-9041-a44bb6b2cab6
date added to LUP
2016-07-07 07:04:17
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2016-12-04 04:52:46
@misc{326fd57c-a93f-4a6d-9041-a44bb6b2cab6,
  abstract     = {<p>BACKGROUND: The aims of the study were to determine the prevalence of cardiometabolic risk factors and establish the proportion of people with psychosis meeting criteria for the metabolic syndrome (MetS). The study also aimed to identify the key lifestyle behaviours associated with increased risk of the MetS and to investigate whether the MetS is associated with illness severity and degree of functional impairment.</p><p>METHOD: Baseline data were collected as part of a large randomized controlled trial (IMPaCT RCT). The study took place within community mental health teams in five Mental Health NHS Trusts in urban and rural locations across England. A total of 450 randomly selected out-patients, aged 18-65 years, with an established psychotic illness were recruited. We ascertained the prevalence rates of cardiometabolic risk factors, illness severity and functional impairment and calculated rates of the MetS, using International Diabetes Federation (IDF) and National Cholesterol Education Program Third Adult Treatment Panel criteria.</p><p>RESULTS: High rates of cardiometabolic risk factors were found. Nearly all women and most men had waist circumference exceeding the IDF threshold for central obesity. Half the sample was obese (body mass index ≥ 30 kg/m2) and a fifth met the criteria for type 2 diabetes mellitus. Females were more likely to be obese than males (61% v. 42%, p &lt; 0.001). Of the 308 patients with complete laboratory measures, 57% (n = 175) met the IDF criteria for the MetS.</p><p>CONCLUSIONS: In the UK, the prevalence of cardiometabolic risk factors in individuals with psychotic illnesses is much higher than that observed in national general population studies as well as in most international studies of patients with psychosis.</p>},
  author       = {Gardner-Sood, P and Lally, J and Smith, S and Atakan, Z and Ismail, K and Greenwood, K E and Keen, A and O'Brien, C and Onagbesan, O and Fung, C and Papanastasiou, E and Eberhard, J and Patel, A and Ohlsen, R and Stahl, D and David, A and Hopkins, D and Murray, R M and Gaughran, F},
  issn         = {1469-8978},
  keyword      = {Adolescent,Adult,Aged,Benzodiazepines,Cardiovascular Diseases,Community Mental Health Centers,Diabetes Mellitus, Type 2,England,Female,Humans,Male,Mental Disorders,Metabolic Syndrome X,Middle Aged,Obesity,Prevalence,Risk Factors,Rural Population,Sex Distribution,State Medicine,Urban Population,Young Adult},
  language     = {eng},
  number       = {12},
  pages        = {29--2619},
  publisher    = {ARRAY(0x80a64d0)},
  series       = {Psychological Medicine},
  title        = {Cardiovascular risk factors and metabolic syndrome in people with established psychotic illnesses : baseline data from the IMPaCT randomized controlled trial},
  url          = {http://dx.doi.org/10.1017/S0033291715000562},
  volume       = {45},
  year         = {2015},
}