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In vivo production of thromboxane and prostacyclin in patients following total hip arthroplasty.

Vesterqvist, O; Schött, Ulf LU ; Berséus, O; Axelsson, K and Gréen, K (1988) In Scandinavian Journal of Clinical & Laboratory Investigation 48(3). p.233-239
Abstract
The in vivo production of thromboxane and prostacyclin was studied by measurements of their major urinary metabolites in eight patients undergoing total hip arthroplasty. Specific methods based on gas chromatography-mass spectrometry were used to measure the urinary excretion of 2,3-dinor-TxB2 and 2,3-dinor-6-keto-PGF1 alpha. The excretion of these metabolites increased about 10-fold during the intra and immediate postoperative period and 4 days after surgery was still higher than during the preoperative period. The increased thromboxane formation reflects probable activation of platelets whereas the increased prostacyclin could be part of a vascular defense against induced thrombotic activity. These findings may have pathophysiological... (More)
The in vivo production of thromboxane and prostacyclin was studied by measurements of their major urinary metabolites in eight patients undergoing total hip arthroplasty. Specific methods based on gas chromatography-mass spectrometry were used to measure the urinary excretion of 2,3-dinor-TxB2 and 2,3-dinor-6-keto-PGF1 alpha. The excretion of these metabolites increased about 10-fold during the intra and immediate postoperative period and 4 days after surgery was still higher than during the preoperative period. The increased thromboxane formation reflects probable activation of platelets whereas the increased prostacyclin could be part of a vascular defense against induced thrombotic activity. These findings may have pathophysiological implications. (Less)
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organization
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Contribution to journal
publication status
published
subject
keywords
6-Ketoprostaglandin F1 alpha: analogs & derivatives, 6-Ketoprostaglandin F1 alpha: urine, Hip Prosthesis: adverse effects, Thrombosis: etiology, Thromboxane B2: analogs & derivatives, Thromboxane B2: urine
in
Scandinavian Journal of Clinical & Laboratory Investigation
volume
48
issue
3
pages
233 - 239
publisher
Informa Healthcare
external identifiers
  • PMID:3375779
  • Scopus:0023908099
ISSN
1502-7686
language
English
LU publication?
yes
id
80182be5-c427-4ddd-94d4-b46810ab61b3 (old id 3634402)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/3375779?dopt=Abstract
date added to LUP
2013-07-02 13:00:10
date last changed
2016-11-27 04:26:43
@misc{80182be5-c427-4ddd-94d4-b46810ab61b3,
  abstract     = {The in vivo production of thromboxane and prostacyclin was studied by measurements of their major urinary metabolites in eight patients undergoing total hip arthroplasty. Specific methods based on gas chromatography-mass spectrometry were used to measure the urinary excretion of 2,3-dinor-TxB2 and 2,3-dinor-6-keto-PGF1 alpha. The excretion of these metabolites increased about 10-fold during the intra and immediate postoperative period and 4 days after surgery was still higher than during the preoperative period. The increased thromboxane formation reflects probable activation of platelets whereas the increased prostacyclin could be part of a vascular defense against induced thrombotic activity. These findings may have pathophysiological implications.},
  author       = {Vesterqvist, O and Schött, Ulf and Berséus, O and Axelsson, K and Gréen, K},
  issn         = {1502-7686},
  keyword      = {6-Ketoprostaglandin F1 alpha: analogs & derivatives,6-Ketoprostaglandin F1 alpha: urine,Hip Prosthesis: adverse effects,Thrombosis: etiology,Thromboxane B2: analogs & derivatives,Thromboxane B2: urine},
  language     = {eng},
  number       = {3},
  pages        = {233--239},
  publisher    = {ARRAY(0xa117e00)},
  series       = {Scandinavian Journal of Clinical & Laboratory Investigation},
  title        = {In vivo production of thromboxane and prostacyclin in patients following total hip arthroplasty.},
  volume       = {48},
  year         = {1988},
}