Advanced

Expression of sterol regulatory element-binding transcription factor (SREBF) 2 and SREBF cleavage-activating protein (SCAP) in human atheroma and the association of their allelic variants with sudden cardiac death.

Fan, Yue-Mei; Karhunen, Pekka J; Levula, Mari; Ilveskoski, Erkki; Mikkelsson, Jussi; Kajander, Olli A; Järvinen, Otso; Oksala, Niku; Thusberg, Janita and Vihinen, Mauno LU , et al. (2008) In Thrombosis Journal 6.
Abstract
Disturbed cellular cholesterol homeostasis may lead to accumulation of cholesterol in human atheroma plaques. Cellular cholesterol homeostasis is controlled by the sterol regulatory element-binding transcription factor 2 (SREBF-2) and the SREBF cleavage-activating protein (SCAP). We investigated whole genome expression in a series of human atherosclerotic samples from different vascular territories and studied whether the non-synonymous coding variants in the interacting domains of two genes, SREBF-2 1784G>C (rs2228314) and SCAP 2386A>G, are related to the progression of coronary atherosclerosis and the risk of pre-hospital sudden cardiac death (SCD).
Please use this url to cite or link to this publication:
author
, et al. (More)
(Less)
publishing date
type
Contribution to journal
publication status
published
subject
in
Thrombosis Journal
volume
6
publisher
BioMed Central
external identifiers
  • PMID:19116028
  • Scopus:62149145092
ISSN
1477-9560
DOI
10.1186/1477-9560-6-17
language
English
LU publication?
no
id
4f7168b3-b923-438e-9a73-2f6b6a30adf6 (old id 3634975)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/19116028?dopt=Abstract
date added to LUP
2013-06-12 16:38:29
date last changed
2016-10-13 04:29:34
@misc{4f7168b3-b923-438e-9a73-2f6b6a30adf6,
  abstract     = {Disturbed cellular cholesterol homeostasis may lead to accumulation of cholesterol in human atheroma plaques. Cellular cholesterol homeostasis is controlled by the sterol regulatory element-binding transcription factor 2 (SREBF-2) and the SREBF cleavage-activating protein (SCAP). We investigated whole genome expression in a series of human atherosclerotic samples from different vascular territories and studied whether the non-synonymous coding variants in the interacting domains of two genes, SREBF-2 1784G>C (rs2228314) and SCAP 2386A>G, are related to the progression of coronary atherosclerosis and the risk of pre-hospital sudden cardiac death (SCD).},
  author       = {Fan, Yue-Mei and Karhunen, Pekka J and Levula, Mari and Ilveskoski, Erkki and Mikkelsson, Jussi and Kajander, Olli A and Järvinen, Otso and Oksala, Niku and Thusberg, Janita and Vihinen, Mauno and Salenius, Juha-Pekka and Kytömäki, Leena and Soini, Juhani T and Laaksonen, Reijo and Lehtimäki, Terho},
  issn         = {1477-9560},
  language     = {eng},
  publisher    = {ARRAY(0x8cda0b0)},
  series       = {Thrombosis Journal},
  title        = {Expression of sterol regulatory element-binding transcription factor (SREBF) 2 and SREBF cleavage-activating protein (SCAP) in human atheroma and the association of their allelic variants with sudden cardiac death.},
  url          = {http://dx.doi.org/10.1186/1477-9560-6-17},
  volume       = {6},
  year         = {2008},
}