Expression of sterol regulatory element-binding transcription factor (SREBF) 2 and SREBF cleavage-activating protein (SCAP) in human atheroma and the association of their allelic variants with sudden cardiac death.
Fan, Yue-Mei ; Karhunen, Pekka J ; Levula, Mari ; Ilveskoski, Erkki ; Mikkelsson, Jussi ; Kajander, Olli A ; Järvinen, Otso ; Oksala, Niku ; Thusberg, Janita and Vihinen, Mauno LU
, et al.
(2008)
In Thrombosis Journal
6.
- Abstract
- Disturbed cellular cholesterol homeostasis may lead to accumulation of cholesterol in human atheroma plaques. Cellular cholesterol homeostasis is controlled by the sterol regulatory element-binding transcription factor 2 (SREBF-2) and the SREBF cleavage-activating protein (SCAP). We investigated whole genome expression in a series of human atherosclerotic samples from different vascular territories and studied whether the non-synonymous coding variants in the interacting domains of two genes, SREBF-2 1784G>C (rs2228314) and SCAP 2386A>G, are related to the progression of coronary atherosclerosis and the risk of pre-hospital sudden cardiac death (SCD).
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/3634975
- author
- Fan, Yue-Mei
; Karhunen, Pekka J
; Levula, Mari
; Ilveskoski, Erkki
; Mikkelsson, Jussi
; Kajander, Olli A
; Järvinen, Otso
; Oksala, Niku
; Thusberg, Janita
and Vihinen, Mauno
LU
, et al. (More)
- Fan, Yue-Mei
; Karhunen, Pekka J
; Levula, Mari
; Ilveskoski, Erkki
; Mikkelsson, Jussi
; Kajander, Olli A
; Järvinen, Otso
; Oksala, Niku
; Thusberg, Janita
; Vihinen, Mauno
LU
; Salenius, Juha-Pekka
; Kytömäki, Leena
; Soini, Juhani T
; Laaksonen, Reijo
and Lehtimäki, Terho
(Less)
- publishing date
- 2008
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Thrombosis Journal
- volume
- 6
- article number
- 17
- publisher
- BioMed Central (BMC)
- external identifiers
-
- pmid:19116028
- scopus:62149145092
- ISSN
- 1477-9560
- DOI
- 10.1186/1477-9560-6-17
- language
- English
- LU publication?
- no
- id
- 4f7168b3-b923-438e-9a73-2f6b6a30adf6 (old id 3634975)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/19116028?dopt=Abstract
- date added to LUP
- 2016-04-04 09:23:10
- date last changed
- 2022-03-15 19:03:31
@article{4f7168b3-b923-438e-9a73-2f6b6a30adf6,
abstract = {{Disturbed cellular cholesterol homeostasis may lead to accumulation of cholesterol in human atheroma plaques. Cellular cholesterol homeostasis is controlled by the sterol regulatory element-binding transcription factor 2 (SREBF-2) and the SREBF cleavage-activating protein (SCAP). We investigated whole genome expression in a series of human atherosclerotic samples from different vascular territories and studied whether the non-synonymous coding variants in the interacting domains of two genes, SREBF-2 1784G>C (rs2228314) and SCAP 2386A>G, are related to the progression of coronary atherosclerosis and the risk of pre-hospital sudden cardiac death (SCD).}},
author = {{Fan, Yue-Mei and Karhunen, Pekka J and Levula, Mari and Ilveskoski, Erkki and Mikkelsson, Jussi and Kajander, Olli A and Järvinen, Otso and Oksala, Niku and Thusberg, Janita and Vihinen, Mauno and Salenius, Juha-Pekka and Kytömäki, Leena and Soini, Juhani T and Laaksonen, Reijo and Lehtimäki, Terho}},
issn = {{1477-9560}},
language = {{eng}},
publisher = {{BioMed Central (BMC)}},
series = {{Thrombosis Journal}},
title = {{Expression of sterol regulatory element-binding transcription factor (SREBF) 2 and SREBF cleavage-activating protein (SCAP) in human atheroma and the association of their allelic variants with sudden cardiac death.}},
url = {{http://dx.doi.org/10.1186/1477-9560-6-17}},
doi = {{10.1186/1477-9560-6-17}},
volume = {{6}},
year = {{2008}},
}