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Interaction between the labile binding site of human C4 and methylamine

Lundwall, Åke LU ; Malmheden, I.; Hellman, U. and Sjoquist, J. (1981) In Scand J Immunol 13(2). p.199-203
Abstract
Human complement component C4 was irreversibly inactivated by low concentrations of methylamine at slightly alkaline pH. The inactivated C4 molecules lost the ability to bind to EAC1 cells but retained th capacity to participate in the formation of classical pathway C3 convertase in the fluid phase. 14C-methylamine was incorporated into the alpha-chain at a ratio of 1 mol methylamine per mol C4.
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author
publishing date
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Contribution to journal
publication status
published
subject
keywords
Humans, Polyacrylamide Gel, Electrophoresis, Complement C4/*antagonists & inhibitors, Complement Inactivator Proteins/pharmacology, Hydrogen-Ion Concentration, Methylamines/*pharmacology, Receptors, Complement/*drug effects, Research Support, Non-U.S. Gov't
in
Scand J Immunol
volume
13
issue
2
pages
199 - 203
external identifiers
  • Scopus:0019464204
language
English
LU publication?
no
id
f77929d1-09f5-462b-a84c-dab567c90fb4 (old id 3965006)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=7233091
date added to LUP
2013-08-11 15:17:37
date last changed
2016-11-27 04:35:01
@misc{f77929d1-09f5-462b-a84c-dab567c90fb4,
  abstract     = {Human complement component C4 was irreversibly inactivated by low concentrations of methylamine at slightly alkaline pH. The inactivated C4 molecules lost the ability to bind to EAC1 cells but retained th capacity to participate in the formation of classical pathway C3 convertase in the fluid phase. 14C-methylamine was incorporated into the alpha-chain at a ratio of 1 mol methylamine per mol C4.},
  author       = {Lundwall, Åke and Malmheden, I. and Hellman, U. and Sjoquist, J.},
  keyword      = {Humans,Polyacrylamide Gel,Electrophoresis,Complement C4/*antagonists & inhibitors,Complement Inactivator Proteins/pharmacology,Hydrogen-Ion Concentration,Methylamines/*pharmacology,Receptors,Complement/*drug effects,Research Support,Non-U.S. Gov't},
  language     = {eng},
  number       = {2},
  pages        = {199--203},
  series       = {Scand J Immunol},
  title        = {Interaction between the labile binding site of human C4 and methylamine},
  volume       = {13},
  year         = {1981},
}