Gene structure of semenogelin I and II. The predominant proteins in human semen are encoded by two homologous genes on chromosome 20
(1992) In Journal of Biological Chemistry 267(25). p.4-18080- Abstract
- The genes for semenogelin I and II, the major protein constituents of the human seminal fluid, have been characterized by three overlapping clones in bacteriophage lambda, encompassing 31.5 kilobases (kb) of genomic DNA. The two genes are located 11.5 kb apart in the region q12-q13.1 on chromosome 20. Both genes are relatively compact, spanning only 2.7 and 3.1 kb, respectively. The transcription units are composed of three exons, of which the first encodes the signal peptide, the second encodes the secreted protein, while the third solely contains 3'-noncoding nucleotides. The nucleotide sequences exhibit a similarity of close to 90% in the exons and exceeding 80% in the introns and flanking nucleotides.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/3965213
- author
- Ulvsbäck, M. ; Lazure, C. ; Lilja, Hans LU ; Spurr, N. K. ; Rao, V. V. ; Loffler, C. ; Hansmann, I. and Lundwall, Åke LU
- organization
- publishing date
- 1992
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Molecular Sequence Data, Male, Humans, Gonadal Steroid Hormones/*genetics, DNA/genetics/isolation & purification, Codon/genetics, Molecular, Cloning, Pair 20, Human, *Chromosomes, Chromosome Mapping, Chromosome Banding, Southern, Blotting, Amino Acid Sequence, Base Sequence, *Multigene Family, Oligodeoxyribonucleotides, Research Support, Non-U.S. Gov't, Restriction Mapping, Semen/*physiology, *Seminal Vesicle Secretory Proteins, Spermatozoa/*physiology
- in
- Journal of Biological Chemistry
- volume
- 267
- issue
- 25
- pages
- 4 - 18080
- publisher
- American Society for Biochemistry and Molecular Biology
- external identifiers
-
- scopus:0026662010
- ISSN
- 0021-9258
- language
- English
- LU publication?
- yes
- additional info
- 25
- id
- 4b793ea3-1803-4da9-b492-ba4739042d68 (old id 3965213)
- alternative location
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=1517240
- date added to LUP
- 2016-04-04 14:37:49
- date last changed
- 2021-01-03 05:25:20
@article{4b793ea3-1803-4da9-b492-ba4739042d68, abstract = {{The genes for semenogelin I and II, the major protein constituents of the human seminal fluid, have been characterized by three overlapping clones in bacteriophage lambda, encompassing 31.5 kilobases (kb) of genomic DNA. The two genes are located 11.5 kb apart in the region q12-q13.1 on chromosome 20. Both genes are relatively compact, spanning only 2.7 and 3.1 kb, respectively. The transcription units are composed of three exons, of which the first encodes the signal peptide, the second encodes the secreted protein, while the third solely contains 3'-noncoding nucleotides. The nucleotide sequences exhibit a similarity of close to 90% in the exons and exceeding 80% in the introns and flanking nucleotides.}}, author = {{Ulvsbäck, M. and Lazure, C. and Lilja, Hans and Spurr, N. K. and Rao, V. V. and Loffler, C. and Hansmann, I. and Lundwall, Åke}}, issn = {{0021-9258}}, keywords = {{Molecular Sequence Data; Male; Humans; Gonadal Steroid Hormones/*genetics; DNA/genetics/isolation & purification; Codon/genetics; Molecular; Cloning; Pair 20; Human; *Chromosomes; Chromosome Mapping; Chromosome Banding; Southern; Blotting; Amino Acid Sequence; Base Sequence; *Multigene Family; Oligodeoxyribonucleotides; Research Support; Non-U.S. Gov't; Restriction Mapping; Semen/*physiology; *Seminal Vesicle Secretory Proteins; Spermatozoa/*physiology}}, language = {{eng}}, number = {{25}}, pages = {{4--18080}}, publisher = {{American Society for Biochemistry and Molecular Biology}}, series = {{Journal of Biological Chemistry}}, title = {{Gene structure of semenogelin I and II. The predominant proteins in human semen are encoded by two homologous genes on chromosome 20}}, url = {{http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=1517240}}, volume = {{267}}, year = {{1992}}, }