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Gene structure of semenogelin I and II. The predominant proteins in human semen are encoded by two homologous genes on chromosome 20

Ulvsbäck, M.; Lazure, C.; Lilja, Hans LU ; Spurr, N. K.; Rao, V. V.; Loffler, C.; Hansmann, I. and Lundwall, Åke LU (1992) In J Biol Chem 267(25). p.4-18080
Abstract
The genes for semenogelin I and II, the major protein constituents of the human seminal fluid, have been characterized by three overlapping clones in bacteriophage lambda, encompassing 31.5 kilobases (kb) of genomic DNA. The two genes are located 11.5 kb apart in the region q12-q13.1 on chromosome 20. Both genes are relatively compact, spanning only 2.7 and 3.1 kb, respectively. The transcription units are composed of three exons, of which the first encodes the signal peptide, the second encodes the secreted protein, while the third solely contains 3'-noncoding nucleotides. The nucleotide sequences exhibit a similarity of close to 90% in the exons and exceeding 80% in the introns and flanking nucleotides.
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keywords
Molecular Sequence Data, Male, Humans, Gonadal Steroid Hormones/*genetics, DNA/genetics/isolation & purification, Codon/genetics, Molecular, Cloning, Pair 20, Human, *Chromosomes, Chromosome Mapping, Chromosome Banding, Southern, Blotting, Amino Acid Sequence, Base Sequence, *Multigene Family, Oligodeoxyribonucleotides, Research Support, Non-U.S. Gov't, Restriction Mapping, Semen/*physiology, *Seminal Vesicle Secretory Proteins, Spermatozoa/*physiology
in
J Biol Chem
volume
267
issue
25
pages
4 - 18080
external identifiers
  • Scopus:0026662010
language
English
LU publication?
yes
id
4b793ea3-1803-4da9-b492-ba4739042d68 (old id 3965213)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=1517240
date added to LUP
2013-08-09 14:39:49
date last changed
2016-10-13 05:03:20
@misc{4b793ea3-1803-4da9-b492-ba4739042d68,
  abstract     = {The genes for semenogelin I and II, the major protein constituents of the human seminal fluid, have been characterized by three overlapping clones in bacteriophage lambda, encompassing 31.5 kilobases (kb) of genomic DNA. The two genes are located 11.5 kb apart in the region q12-q13.1 on chromosome 20. Both genes are relatively compact, spanning only 2.7 and 3.1 kb, respectively. The transcription units are composed of three exons, of which the first encodes the signal peptide, the second encodes the secreted protein, while the third solely contains 3'-noncoding nucleotides. The nucleotide sequences exhibit a similarity of close to 90% in the exons and exceeding 80% in the introns and flanking nucleotides.},
  author       = {Ulvsbäck, M. and Lazure, C. and Lilja, Hans and Spurr, N. K. and Rao, V. V. and Loffler, C. and Hansmann, I. and Lundwall, Åke},
  keyword      = {Molecular Sequence Data,Male,Humans,Gonadal Steroid Hormones/*genetics,DNA/genetics/isolation & purification,Codon/genetics,Molecular,Cloning,Pair 20,Human,*Chromosomes,Chromosome Mapping,Chromosome Banding,Southern,Blotting,Amino Acid Sequence,Base Sequence,*Multigene Family,Oligodeoxyribonucleotides,Research Support,Non-U.S. Gov't,Restriction Mapping,Semen/*physiology,*Seminal Vesicle Secretory Proteins,Spermatozoa/*physiology},
  language     = {eng},
  number       = {25},
  pages        = {4--18080},
  series       = {J Biol Chem},
  title        = {Gene structure of semenogelin I and II. The predominant proteins in human semen are encoded by two homologous genes on chromosome 20},
  volume       = {267},
  year         = {1992},
}