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The structure of the semenogelin gene locus--nucleotide sequence of the intergenic and the flanking DNA

Lundwall, Åke LU (1996) In Eur J Biochem 235(3). p.466-70
Abstract
The sequence of 15.7 kb from the human semenogelin gene locus has been determined. Together with previously published sequences, this gives the structure of a 28-kb region encompassing the two semenogelin genes. The two transcription units are separated by 11616 bp intergenic DNA comprising more than 40% repetitive DNA sequences, predominantly located to a 4-kb block of L1 and Alu repeats. Two more blocks of L1 sequences are present in the DNA flanking the genes, so that approximately 20% of the completed sequence consists of long interspersed repeated sequences, so called LINES. A comparison of the SgI gene and the SgII gene suggests that they evolved by the duplication of an approximately 8 kb DNA segment about 61 million years ago,... (More)
The sequence of 15.7 kb from the human semenogelin gene locus has been determined. Together with previously published sequences, this gives the structure of a 28-kb region encompassing the two semenogelin genes. The two transcription units are separated by 11616 bp intergenic DNA comprising more than 40% repetitive DNA sequences, predominantly located to a 4-kb block of L1 and Alu repeats. Two more blocks of L1 sequences are present in the DNA flanking the genes, so that approximately 20% of the completed sequence consists of long interspersed repeated sequences, so called LINES. A comparison of the SgI gene and the SgII gene suggests that they evolved by the duplication of an approximately 8 kb DNA segment about 61 million years ago, probably by a mechanism involving recombination between L1 elements. (Less)
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organization
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Contribution to journal
publication status
published
subject
keywords
Repetitive Sequences, Multigene Family, Molecular Sequence Data, Humans, Gonadal Steroid Hormones/*genetics, Dna, Molecular, Cloning, Base Sequence, Chromosome Mapping, Nucleic Acid, Non-U.S. Gov't, Research Support, *Seminal Vesicle Secretory Proteins, Sequence Homology
in
Eur J Biochem
volume
235
issue
3
pages
466 - 70
external identifiers
  • Scopus:0030047134
language
English
LU publication?
yes
id
75372628-4f4f-4e47-ac9b-2d7729a49772 (old id 3965245)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=8654389
date added to LUP
2013-08-11 19:04:42
date last changed
2016-04-16 12:21:03
@misc{75372628-4f4f-4e47-ac9b-2d7729a49772,
  abstract     = {The sequence of 15.7 kb from the human semenogelin gene locus has been determined. Together with previously published sequences, this gives the structure of a 28-kb region encompassing the two semenogelin genes. The two transcription units are separated by 11616 bp intergenic DNA comprising more than 40% repetitive DNA sequences, predominantly located to a 4-kb block of L1 and Alu repeats. Two more blocks of L1 sequences are present in the DNA flanking the genes, so that approximately 20% of the completed sequence consists of long interspersed repeated sequences, so called LINES. A comparison of the SgI gene and the SgII gene suggests that they evolved by the duplication of an approximately 8 kb DNA segment about 61 million years ago, probably by a mechanism involving recombination between L1 elements.},
  author       = {Lundwall, Åke},
  keyword      = {Repetitive Sequences,Multigene Family,Molecular Sequence Data,Humans,Gonadal Steroid Hormones/*genetics,Dna,Molecular,Cloning,Base Sequence,Chromosome Mapping,Nucleic Acid,Non-U.S. Gov't,Research Support,*Seminal Vesicle Secretory Proteins,Sequence Homology},
  language     = {eng},
  number       = {3},
  pages        = {466--70},
  series       = {Eur J Biochem},
  title        = {The structure of the semenogelin gene locus--nucleotide sequence of the intergenic and the flanking DNA},
  volume       = {235},
  year         = {1996},
}