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Segmental variation in microstructure, matrix synthesis and cell proliferation in rabbit flexor tendon

Abrahamsson, Sven Olof LU ; Lundborg, Goran and Lohmander, Stefan LU (1989) In Scandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery 23(3). p.191-198
Abstract

An experimental culture system was designed with the purpose of studying matrix synthesis and cell proliferation in the deep flexor tendon of the rabbit fore-paw. Special attention was paid to differences between three consecutive defined segments of the tendon from the region of the tendon sheath. There were two fibrocartilaginous areas in the tendon, one in the dorsal part of the proximal segment and one in the volar part of the distal segment. The intermediate segment consisted of regular tendinous tissue. The dorsal aspect of the distal segment was further characterized by a cell rich area related to the entrance of the vinculum longum. Proteoglycan synthesis in vitro was higher in the proximal and distal segments than in the... (More)

An experimental culture system was designed with the purpose of studying matrix synthesis and cell proliferation in the deep flexor tendon of the rabbit fore-paw. Special attention was paid to differences between three consecutive defined segments of the tendon from the region of the tendon sheath. There were two fibrocartilaginous areas in the tendon, one in the dorsal part of the proximal segment and one in the volar part of the distal segment. The intermediate segment consisted of regular tendinous tissue. The dorsal aspect of the distal segment was further characterized by a cell rich area related to the entrance of the vinculum longum. Proteoglycan synthesis in vitro was higher in the proximal and distal segments than in the intermediate, while collagen synthesis was highest in the intermediate tendinous segment. Variations in collagen content were reflected in variations in collagen synthesis. The rate of cell proliferation was highest in the intermediate segment. Segmental biochemical characteristics correlated well with morphological variations of the deep flexor tendon. These variations may reflect an adaptation to different mechanical forces acting on the tendon. The segmental variations may also be relevant for the healing capacity of the flexor tendon. © 1989 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Anatomy, Cell proliferation, Collagen, Histology, Protein, Proteoglycan, Tendon
in
Scandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery
volume
23
issue
3
pages
8 pages
publisher
Taylor & Francis
external identifiers
  • Scopus:0024786229
ISSN
0284-4311
DOI
10.3109/02844318909075117
language
English
LU publication?
yes
id
3be54c50-19d9-4c88-b69e-fc34895b039a
date added to LUP
2016-05-04 18:09:27
date last changed
2016-07-07 14:37:48
@misc{3be54c50-19d9-4c88-b69e-fc34895b039a,
  abstract     = {<p>An experimental culture system was designed with the purpose of studying matrix synthesis and cell proliferation in the deep flexor tendon of the rabbit fore-paw. Special attention was paid to differences between three consecutive defined segments of the tendon from the region of the tendon sheath. There were two fibrocartilaginous areas in the tendon, one in the dorsal part of the proximal segment and one in the volar part of the distal segment. The intermediate segment consisted of regular tendinous tissue. The dorsal aspect of the distal segment was further characterized by a cell rich area related to the entrance of the vinculum longum. Proteoglycan synthesis in vitro was higher in the proximal and distal segments than in the intermediate, while collagen synthesis was highest in the intermediate tendinous segment. Variations in collagen content were reflected in variations in collagen synthesis. The rate of cell proliferation was highest in the intermediate segment. Segmental biochemical characteristics correlated well with morphological variations of the deep flexor tendon. These variations may reflect an adaptation to different mechanical forces acting on the tendon. The segmental variations may also be relevant for the healing capacity of the flexor tendon. © 1989 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.</p>},
  author       = {Abrahamsson, Sven Olof and Lundborg, Goran and Lohmander, Stefan},
  issn         = {0284-4311},
  keyword      = {Anatomy,Cell proliferation,Collagen,Histology,Protein,Proteoglycan,Tendon},
  language     = {eng},
  number       = {3},
  pages        = {191--198},
  publisher    = {ARRAY(0x909c4b0)},
  series       = {Scandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery},
  title        = {Segmental variation in microstructure, matrix synthesis and cell proliferation in rabbit flexor tendon},
  url          = {http://dx.doi.org/10.3109/02844318909075117},
  volume       = {23},
  year         = {1989},
}