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Long term recurrence and survival following robotic radical hysterectomy for early stage cervical cancer.

Reynisson, Petur LU and Persson, Jan LU (2013) In Unpublished
Abstract
Objective: To evaluate long-term oncological outcome and surgical quality of robotic radical hysterectomy for cervical cancer.

Methods: Consecutive women with stage IA2 to IIA operated between March 2006 and May 2012 with a robotic radical hysterectomy and pelvic lymphadenectomy were prospectively followed up until five years after surgery or until death. Details regarding clinical results, recurrence and death from disease were analysed and compared with FIGO survival data and EORTC-GCG quality parameters.

Results: Of 170 included women; two were lost to follow up leaving 168 for analysis (16% stage IA2, 73% stage IB1 and 11% stage ≥ IB2). 22% had positive lymph nodes and 40% received postoperative chemoradiation. Median... (More)
Objective: To evaluate long-term oncological outcome and surgical quality of robotic radical hysterectomy for cervical cancer.

Methods: Consecutive women with stage IA2 to IIA operated between March 2006 and May 2012 with a robotic radical hysterectomy and pelvic lymphadenectomy were prospectively followed up until five years after surgery or until death. Details regarding clinical results, recurrence and death from disease were analysed and compared with FIGO survival data and EORTC-GCG quality parameters.

Results: Of 170 included women; two were lost to follow up leaving 168 for analysis (16% stage IA2, 73% stage IB1 and 11% stage ≥ IB2). 22% had positive lymph nodes and 40% received postoperative chemoradiation. Median follow up was 46.5 months (range 6-91 months). A total of 21 women (12%) recurred of which nine women (5%) had a locoregional pelvic recurrence and 12 women had (7%) had a distant recurrence. Three and five year recurrence free survival was 93% and 89% respectively and over all survival was 96% and 93% respectively. Port site recurrences occurred in two patients, one having a node positive stage IB1 neuroendocrine cancer, and the other having a stageIB2 mucinous adenocarcinoma with multiple nodal metastases and micro-metastases on both adnexa. Both of them have died in their disease. No other recurrences possibly associated with the surgical technique per se occurred.

Conclusion: Survival and recurrence data are comparable with FIGO reports and quality levels suggested by the EORTC-GCG. The EORTC-GCG surgical / clinical quality parameters were met for 16 of 19 criteria. The overall results do not raise concerns regarding the oncological outcome following robot-assisted surgery for early cervical cancer. The port site recurrences may be related to the tumour biology of the high-risk histologies, the surgical technique per se or a combination of those. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
unpublished
subject
keywords
Cervical cancer, robotic surgery, radical hysterectomy, survival, recurrence.
in
Unpublished
language
English
LU publication?
yes
id
bb24def7-321d-4449-8908-5b8b503d9c60 (old id 4128328)
date added to LUP
2016-02-08 12:30:19
date last changed
2016-04-16 12:29:52
@misc{bb24def7-321d-4449-8908-5b8b503d9c60,
  abstract     = {Objective: To evaluate long-term oncological outcome and surgical quality of robotic radical hysterectomy for cervical cancer.<br/><br>
Methods: Consecutive women with stage IA2 to IIA operated between March 2006 and May 2012 with a robotic radical hysterectomy and pelvic lymphadenectomy were prospectively followed up until five years after surgery or until death. Details regarding clinical results, recurrence and death from disease were analysed and compared with FIGO survival data and EORTC-GCG quality parameters.<br/><br>
Results: Of 170 included women; two were lost to follow up leaving 168 for analysis (16% stage IA2, 73% stage IB1 and 11% stage ≥ IB2). 22% had positive lymph nodes and 40% received postoperative chemoradiation. Median follow up was 46.5 months (range 6-91 months). A total of 21 women (12%) recurred of which nine women (5%) had a locoregional pelvic recurrence and 12 women had (7%) had a distant recurrence. Three and five year recurrence free survival was 93% and 89% respectively and over all survival was 96% and 93% respectively. Port site recurrences occurred in two patients, one having a node positive stage IB1 neuroendocrine cancer, and the other having a stageIB2 mucinous adenocarcinoma with multiple nodal metastases and micro-metastases on both adnexa. Both of them have died in their disease. No other recurrences possibly associated with the surgical technique per se occurred.<br/><br>
Conclusion: Survival and recurrence data are comparable with FIGO reports and quality levels suggested by the EORTC-GCG. The EORTC-GCG surgical / clinical quality parameters were met for 16 of 19 criteria. The overall results do not raise concerns regarding the oncological outcome following robot-assisted surgery for early cervical cancer. The port site recurrences may be related to the tumour biology of the high-risk histologies, the surgical technique per se or a combination of those.},
  author       = {Reynisson, Petur and Persson, Jan},
  keyword      = {Cervical cancer,robotic surgery,radical hysterectomy,survival,recurrence.},
  language     = {eng},
  series       = {Unpublished},
  title        = {Long term recurrence and survival following robotic radical hysterectomy for early stage cervical cancer.},
  year         = {2013},
}