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Restorative and neuroprotective treatment strategies for Parkinson’s disease: tudies on fetal dopamine cell transplants and GDNF delivery by intracerebral injections and recombinant AAV vectors.

Kirik, Deniz LU (2001)
Abstract
The intrastriatal 6-hydroxydopamine lesion model in rats is particularly useful in studies testing new therapeutic strategies for Parkinson’s disease. This thesis work (1) describes the characterization of the motor deficits after different types of intrastriatal lesions and identifies the four-site terminal lesion as a model of symptomatic Parkinson’s disease; (2) using the same model, provides evidence that the functional impact of the dopamine cell grafts are dependent on interactions with the host brain; (3) demonstrates that protection or restitution of normal motor function after 6-hydroxydopamine lesions can be achieved if glial cell line-derived neurotrophic factor is administered in the striatum at the time of the terminal fiber... (More)
The intrastriatal 6-hydroxydopamine lesion model in rats is particularly useful in studies testing new therapeutic strategies for Parkinson’s disease. This thesis work (1) describes the characterization of the motor deficits after different types of intrastriatal lesions and identifies the four-site terminal lesion as a model of symptomatic Parkinson’s disease; (2) using the same model, provides evidence that the functional impact of the dopamine cell grafts are dependent on interactions with the host brain; (3) demonstrates that protection or restitution of normal motor function after 6-hydroxydopamine lesions can be achieved if glial cell line-derived neurotrophic factor is administered in the striatum at the time of the terminal fiber degeneration. The findings have implications for the development of effective neuroprotective and restorative therapeutic interventions for Parkinson’s disease. (Less)
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author
opponent
  • Prof Dunnett, Stephen B.
organization
publishing date
type
Thesis
publication status
published
subject
keywords
adeno-associated virus, regeneration, neuroprotection, glial-cell-line-derived-neurotrophic factor, cell death, substantia nigra, dopamine, neurofysiologi, neuropsykologi, Neurologi, neurophysiology, neuropsychology, Neurology, tyrosine hydroxylase, sensorimotor behavior, transplantation, gene therapy
pages
172 pages
publisher
Department of Physiological Sciences, Lund University
defense location
Segerfalksalen, Wallenberg Neurocentrum, Lund
defense date
2001-03-16 10:15
ISBN
91-628-4679-5
language
English
LU publication?
yes
id
d7f62e21-99fa-4c2e-81d4-2c045f6e41fb (old id 41285)
date added to LUP
2007-06-21 11:49:01
date last changed
2016-09-19 08:45:10
@misc{d7f62e21-99fa-4c2e-81d4-2c045f6e41fb,
  abstract     = {The intrastriatal 6-hydroxydopamine lesion model in rats is particularly useful in studies testing new therapeutic strategies for Parkinson’s disease. This thesis work (1) describes the characterization of the motor deficits after different types of intrastriatal lesions and identifies the four-site terminal lesion as a model of symptomatic Parkinson’s disease; (2) using the same model, provides evidence that the functional impact of the dopamine cell grafts are dependent on interactions with the host brain; (3) demonstrates that protection or restitution of normal motor function after 6-hydroxydopamine lesions can be achieved if glial cell line-derived neurotrophic factor is administered in the striatum at the time of the terminal fiber degeneration. The findings have implications for the development of effective neuroprotective and restorative therapeutic interventions for Parkinson’s disease.},
  author       = {Kirik, Deniz},
  isbn         = {91-628-4679-5},
  keyword      = {adeno-associated virus,regeneration,neuroprotection,glial-cell-line-derived-neurotrophic factor,cell death,substantia nigra,dopamine,neurofysiologi,neuropsykologi,Neurologi,neurophysiology,neuropsychology,Neurology,tyrosine hydroxylase,sensorimotor behavior,transplantation,gene therapy},
  language     = {eng},
  pages        = {172},
  publisher    = {ARRAY(0x8c35fb0)},
  title        = {Restorative and neuroprotective treatment strategies for Parkinson’s disease: tudies on fetal dopamine cell transplants and GDNF delivery by intracerebral injections and recombinant AAV vectors.},
  year         = {2001},
}