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Division of flexor tendons causes progressive degradation of tendon matrix in rabbits

Wiig, Monica; Hanff, Gunnar; Abrahamsson, Sven Olof LU and Lohmander, L. Stefan LU (1996) In Acta Orthopaedica Scandinavica 67(5). p.491-497
Abstract

Deep flexor tendons of 30 rabbits were divided at the ankle level. The effects of unloading on the synthesis and content of matrix components, the synthesis of DNA, and dry weight were investigated. The reaction of the fibrocartilaginous and non-fibrocartilaginous segments were separately analyzed. The ability of the tendons to synthesize collagen during short-term culture and the contents of matrix components decreased inversely to the time of unloading. 12 weeks following division, the fibrocartilaginous segments had lost 2/5 of their dry weight, 2/3 of proteoglycan and 1/3 of collagen and non-collagen protein content. Less pronounced losses were observed in the non-fibrocartilaginous segments. A transient increase in cell... (More)

Deep flexor tendons of 30 rabbits were divided at the ankle level. The effects of unloading on the synthesis and content of matrix components, the synthesis of DNA, and dry weight were investigated. The reaction of the fibrocartilaginous and non-fibrocartilaginous segments were separately analyzed. The ability of the tendons to synthesize collagen during short-term culture and the contents of matrix components decreased inversely to the time of unloading. 12 weeks following division, the fibrocartilaginous segments had lost 2/5 of their dry weight, 2/3 of proteoglycan and 1/3 of collagen and non-collagen protein content. Less pronounced losses were observed in the non-fibrocartilaginous segments. A transient increase in cell proliferation in both types of segments was found. These findings indicate that divided flexor tendons undergo a progressive degradation, which may have implications for delayed suture of deep flexor tendon injuries.

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publication status
published
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in
Acta Orthopaedica Scandinavica
volume
67
issue
5
pages
7 pages
publisher
Taylor & Francis
external identifiers
  • Scopus:0029844216
ISSN
0001-6470
language
English
LU publication?
yes
id
41898a68-318a-45de-b36c-ff37fcfcdcbb
date added to LUP
2016-05-04 23:52:27
date last changed
2016-08-02 16:20:53
@misc{41898a68-318a-45de-b36c-ff37fcfcdcbb,
  abstract     = {<p>Deep flexor tendons of 30 rabbits were divided at the ankle level. The effects of unloading on the synthesis and content of matrix components, the synthesis of DNA, and dry weight were investigated. The reaction of the fibrocartilaginous and non-fibrocartilaginous segments were separately analyzed. The ability of the tendons to synthesize collagen during short-term culture and the contents of matrix components decreased inversely to the time of unloading. 12 weeks following division, the fibrocartilaginous segments had lost 2/5 of their dry weight, 2/3 of proteoglycan and 1/3 of collagen and non-collagen protein content. Less pronounced losses were observed in the non-fibrocartilaginous segments. A transient increase in cell proliferation in both types of segments was found. These findings indicate that divided flexor tendons undergo a progressive degradation, which may have implications for delayed suture of deep flexor tendon injuries.</p>},
  author       = {Wiig, Monica and Hanff, Gunnar and Abrahamsson, Sven Olof and Lohmander, L. Stefan},
  issn         = {0001-6470},
  language     = {eng},
  number       = {5},
  pages        = {491--497},
  publisher    = {ARRAY(0xa5f4478)},
  series       = {Acta Orthopaedica Scandinavica},
  title        = {Division of flexor tendons causes progressive degradation of tendon matrix in rabbits},
  volume       = {67},
  year         = {1996},
}