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Secondary Metabolites from Bolivian Plants- Isolation and Characterization

Davila, Marcelo LU (2014)
Abstract (Swedish)
Popular Abstract in English

Plants produce an array of organic chemicals with an enormous diversity of structural types. Many of these phytochemicals are biologically active compounds necessary for the well-being, survival, and evolution of the plants, but also have been used by humans, who have used them in traditional medicine and for pharmaceutical industry.

During the course of this research, the natural products isolated from four endemic or medicinal plant species of Bolivia are presented, as well as the techniques and processes through which have been isolated and identified. It also contains the biological activities reported in the literature.
Abstract
Nature has been recognized as a rich source of potentially useful chemicals. Throughout the years, phytochemical studies have led to the discovery of an enormous number of natural products, their chemical diversity is unique and many of them possess various biological activities. As a contribution, this thesis presents the results obtained from the phytochemical study of four Bolivian plants. Senecio clivicolus, Prumnopitys exigua, Baccharis polycephala and Podocarpus parlatorei, which all are species that grow naturally in Bolivia. The study is based on the isolation, purification and spectroscopic characterization of secondary metabolites. To achieve this, various chromatographic methods have been applied to the crude plant extracts in... (More)
Nature has been recognized as a rich source of potentially useful chemicals. Throughout the years, phytochemical studies have led to the discovery of an enormous number of natural products, their chemical diversity is unique and many of them possess various biological activities. As a contribution, this thesis presents the results obtained from the phytochemical study of four Bolivian plants. Senecio clivicolus, Prumnopitys exigua, Baccharis polycephala and Podocarpus parlatorei, which all are species that grow naturally in Bolivia. The study is based on the isolation, purification and spectroscopic characterization of secondary metabolites. To achieve this, various chromatographic methods have been applied to the crude plant extracts in order to fractionate them to the point that pure compounds are obtained. Once a natural product is isolated, it was subjected to high-resolution mass spectrometry to determine its elemental composition and NMR spectroscopy to elucidate the molecular structure. (Less)
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author
supervisor
opponent
  • Professor Pena Rodriguez, Luis Manuel, Centro de Investigación Científica de Yucatán, Yucatán, México.
organization
publishing date
type
Thesis
publication status
published
subject
keywords
Phytochemistry, Natural Prodcuts
pages
77 pages
publisher
Lund University
defense location
Lecture hall F, Center of Chemistry and Chemical Engineering, Getingevägen 60, Lund University Faculty of Engineering, Lund
defense date
2014-10-02 09:30
ISBN
978-91-7422-363-7
language
English
LU publication?
yes
id
a8edb07b-37d7-47ae-8b1e-dc2695202986 (old id 4612476)
date added to LUP
2014-09-08 09:29:15
date last changed
2016-09-19 08:45:07
@misc{a8edb07b-37d7-47ae-8b1e-dc2695202986,
  abstract     = {Nature has been recognized as a rich source of potentially useful chemicals. Throughout the years, phytochemical studies have led to the discovery of an enormous number of natural products, their chemical diversity is unique and many of them possess various biological activities. As a contribution, this thesis presents the results obtained from the phytochemical study of four Bolivian plants. Senecio clivicolus, Prumnopitys exigua, Baccharis polycephala and Podocarpus parlatorei, which all are species that grow naturally in Bolivia. The study is based on the isolation, purification and spectroscopic characterization of secondary metabolites. To achieve this, various chromatographic methods have been applied to the crude plant extracts in order to fractionate them to the point that pure compounds are obtained. Once a natural product is isolated, it was subjected to high-resolution mass spectrometry to determine its elemental composition and NMR spectroscopy to elucidate the molecular structure.},
  author       = {Davila, Marcelo},
  isbn         = {978-91-7422-363-7},
  keyword      = {Phytochemistry,Natural Prodcuts},
  language     = {eng},
  pages        = {77},
  publisher    = {ARRAY(0x9a19d68)},
  title        = {Secondary Metabolites from Bolivian Plants- Isolation and Characterization},
  year         = {2014},
}