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Interstitial Laser Thermotherapy of Liver Tumours. Methodology and Application

Möller, Páll Helgi LU (2004)
Abstract (Swedish)
Popular Abstract in Swedish

Värmebehandling (termoterapi) av tumör baseras på kunskap om den celldödande effekten av värme. Den har begränsats av svårigheten att kontrollera temperaturutbredningen så att en selektiv och tillräcklig effekt erhålls, och detta gäller särskilt djupt belägna tumörer. Interstitiell laser termoterapi (ILT) med Nd:YAG laser är en ny behandlingsform som ger de tekniska förutsättningarna för selektiv värmebehandling. Ljuset från en sådan laser kan ledas i böjliga kvartsfibrer direkt till vävnaden och ger god vävnadspenetration. Avsikten med ILT är att ge kontrollerad värmebehandling så att man får koagulering av vävnaden men inte karbonisering (förkolning) vilket ger dålig ljuspenetration. För... (More)
Popular Abstract in Swedish

Värmebehandling (termoterapi) av tumör baseras på kunskap om den celldödande effekten av värme. Den har begränsats av svårigheten att kontrollera temperaturutbredningen så att en selektiv och tillräcklig effekt erhålls, och detta gäller särskilt djupt belägna tumörer. Interstitiell laser termoterapi (ILT) med Nd:YAG laser är en ny behandlingsform som ger de tekniska förutsättningarna för selektiv värmebehandling. Ljuset från en sådan laser kan ledas i böjliga kvartsfibrer direkt till vävnaden och ger god vävnadspenetration. Avsikten med ILT är att ge kontrollerad värmebehandling så att man får koagulering av vävnaden men inte karbonisering (förkolning) vilket ger dålig ljuspenetration. För kurativt syftande behandling är hypotesen att resultatet kan bli bättre än sedvanlig kirurgisk behandling genom att behandlingstraumat minskar och genom att specifika eller ospecifika immunologiska mekanismer aktiveras.



I experimentella arbeten har vi utvecklat ett sys (Less)
Abstract
Interstitial laser thermotherapy (ILT) is a method well suited for selective local destruction of malignant tumours. In the present work, a laser thermotherapy system based on feedback temperature control of energy delivery (through computerised feedback system) was developed. Temperature control was excellent in experiments without carbonization and with preserved light penetration, whereas temperature oscillations were in experiments with carbonization and impaired light penetration. Using bare fibre, carbonization was seen in almost all experiments in vitro, regardless of output power (1-4 W) but only occasionally in vivo using 2 W. Treatment with a sapphire prob, representing a diffuser tip, gave carbonization at higher output powers... (More)
Interstitial laser thermotherapy (ILT) is a method well suited for selective local destruction of malignant tumours. In the present work, a laser thermotherapy system based on feedback temperature control of energy delivery (through computerised feedback system) was developed. Temperature control was excellent in experiments without carbonization and with preserved light penetration, whereas temperature oscillations were in experiments with carbonization and impaired light penetration. Using bare fibre, carbonization was seen in almost all experiments in vitro, regardless of output power (1-4 W) but only occasionally in vivo using 2 W. Treatment with a sapphire prob, representing a diffuser tip, gave carbonization at higher output powers (> 3 W in vitro, > W in vivo). The bare fibre gave a steeper temperature gradient than the sapphire probe. In normal pig liver the volume of thermal damage was increased five times by occluding the blood flow to the liver during treatment. It was not possible to predic (Less)
Please use this url to cite or link to this publication:
author
opponent
  • Docent Schröder, Tom, Helsinki, Finland
organization
publishing date
type
Thesis
publication status
published
subject
keywords
Resection, Liver, Neoplasm, Blood flow, Monitoring, Feedback control, Light penetration, Bare fibre, Sapphire probe, Nd:YAG laser, Interstitial thermotherapy, Hyperthermia, Surgery, orthopaedics, traumatology, Kirurgi, ortopedi, traumatologi
pages
196 pages
publisher
Páll Helgi Möller, M.D., Department of Surgery, University Hospital, S-221 85 Lund, Sweden,
defense location
Lecture room 1, Central Building, University Hospital, Lund
defense date
1997-05-17 10:15
external identifiers
  • Other:ISRN: LUMEDW/MESL--1097--SE
language
English
LU publication?
yes
id
c0bdec3c-360c-4651-adac-0ddcafe23981 (old id 466846)
date added to LUP
2007-09-25 14:12:48
date last changed
2016-09-19 08:45:03
@misc{c0bdec3c-360c-4651-adac-0ddcafe23981,
  abstract     = {Interstitial laser thermotherapy (ILT) is a method well suited for selective local destruction of malignant tumours. In the present work, a laser thermotherapy system based on feedback temperature control of energy delivery (through computerised feedback system) was developed. Temperature control was excellent in experiments without carbonization and with preserved light penetration, whereas temperature oscillations were in experiments with carbonization and impaired light penetration. Using bare fibre, carbonization was seen in almost all experiments in vitro, regardless of output power (1-4 W) but only occasionally in vivo using 2 W. Treatment with a sapphire prob, representing a diffuser tip, gave carbonization at higher output powers (> 3 W in vitro, > W in vivo). The bare fibre gave a steeper temperature gradient than the sapphire probe. In normal pig liver the volume of thermal damage was increased five times by occluding the blood flow to the liver during treatment. It was not possible to predic},
  author       = {Möller, Páll Helgi},
  keyword      = {Resection,Liver,Neoplasm,Blood flow,Monitoring,Feedback control,Light penetration,Bare fibre,Sapphire probe,Nd:YAG laser,Interstitial thermotherapy,Hyperthermia,Surgery,orthopaedics,traumatology,Kirurgi,ortopedi,traumatologi},
  language     = {eng},
  pages        = {196},
  publisher    = {ARRAY(0xb7d4598)},
  title        = {Interstitial Laser Thermotherapy of Liver Tumours. Methodology and Application},
  year         = {2004},
}