The intracellular distribution of Cobalt in exposed and unexposed rat myocardium
(1990) In Scandinavian Journal of Clinical & Laboratory Investigation 50(6). p.605-609- Abstract
The intracellular distribution of cobalt was analysed in the myocardium of exposed and unexposed rats. The exposed rats were given a dietary cobalt supplementation of 40 mg CoS04-7 H20/kg body weight for 8 weeks. The mitochondrial fraction showed the greatest relative increase in cobalt: 0.09 ng/mg protein in the unexposed rats to 8.43 ng/mg protein in the exposed rats. In the exposed rats the submitochondrial particles had the highest levels of cobalt: 19.43 ng/mg protein, followed by the sarcoplasmatic reticulum: 12.3 ng/mg protein. The microsomal 44 000g supernatant also showed an increase, although the levels remained low (0.51 ng/mg protein in the exposed animals). Apparently the calcium-storing organelles had... (More)
The intracellular distribution of cobalt was analysed in the myocardium of exposed and unexposed rats. The exposed rats were given a dietary cobalt supplementation of 40 mg CoS04-7 H20/kg body weight for 8 weeks. The mitochondrial fraction showed the greatest relative increase in cobalt: 0.09 ng/mg protein in the unexposed rats to 8.43 ng/mg protein in the exposed rats. In the exposed rats the submitochondrial particles had the highest levels of cobalt: 19.43 ng/mg protein, followed by the sarcoplasmatic reticulum: 12.3 ng/mg protein. The microsomal 44 000g supernatant also showed an increase, although the levels remained low (0.51 ng/mg protein in the exposed animals). Apparently the calcium-storing organelles had the highest levels of cobalt. This could affect calcium flux in myocardial cells and, secondarily, tension development in cardiac muscle.
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- author
- Clyne, N. LU ; Persson, B. ; Havu, N. ; Hultman, E. ; Lins, L. E. ; Pehrsson, S. K. ; Rydstrom, J. and Wibom, R.
- publishing date
- 1990
- type
- Contribution to journal
- publication status
- published
- keywords
- Cobalt, Rat myocardium, Subcellular fractions
- in
- Scandinavian Journal of Clinical & Laboratory Investigation
- volume
- 50
- issue
- 6
- pages
- 5 pages
- publisher
- Informa Healthcare
- external identifiers
-
- pmid:2247766
- scopus:0025061243
- ISSN
- 0036-5513
- DOI
- 10.3109/00365519009089177
- language
- English
- LU publication?
- no
- id
- 485e399e-f314-45a0-a860-1fb8f29ab764
- date added to LUP
- 2016-08-30 22:07:17
- date last changed
- 2024-01-04 11:47:54
@article{485e399e-f314-45a0-a860-1fb8f29ab764, abstract = {{<p>The intracellular distribution of cobalt was analysed in the myocardium of exposed and unexposed rats. The exposed rats were given a dietary cobalt supplementation of 40 mg CoS0<sub>4</sub>-7 H<sub>2</sub>0/kg body weight for 8 weeks. The mitochondrial fraction showed the greatest relative increase in cobalt: 0.09 ng/mg protein in the unexposed rats to 8.43 ng/mg protein in the exposed rats. In the exposed rats the submitochondrial particles had the highest levels of cobalt: 19.43 ng/mg protein, followed by the sarcoplasmatic reticulum: 12.3 ng/mg protein. The microsomal 44 000g supernatant also showed an increase, although the levels remained low (0.51 ng/mg protein in the exposed animals). Apparently the calcium-storing organelles had the highest levels of cobalt. This could affect calcium flux in myocardial cells and, secondarily, tension development in cardiac muscle.</p>}}, author = {{Clyne, N. and Persson, B. and Havu, N. and Hultman, E. and Lins, L. E. and Pehrsson, S. K. and Rydstrom, J. and Wibom, R.}}, issn = {{0036-5513}}, keywords = {{Cobalt; Rat myocardium; Subcellular fractions}}, language = {{eng}}, number = {{6}}, pages = {{605--609}}, publisher = {{Informa Healthcare}}, series = {{Scandinavian Journal of Clinical & Laboratory Investigation}}, title = {{The intracellular distribution of Cobalt in exposed and unexposed rat myocardium}}, url = {{http://dx.doi.org/10.3109/00365519009089177}}, doi = {{10.3109/00365519009089177}}, volume = {{50}}, year = {{1990}}, }