Advanced

Quantifying dispersion of finite-sized particles in deterministic lateral displacement microflow separators through Brenner's macrotransport paradigm

Cerbelli, Stefano; Giona, Massimiliano and Garofalo, Fabio LU (2013) In Microfluidics and Nanofluidics 15(4). p.431-449
Abstract

Deterministic lateral displacement provides a novel and efficient technique for sorting micrometer-sized particles based on particle size. It is grounded on the principle that the paths associated with particles of different diameters, entrained in flow streaming through a periodic lattice of obstacles, are characterized by different deflection angles with respect to the average direction of the carrier flow. Theoretical approaches have been developed, which predict quantitatively the dependence of the average deflection angle on particle size. In this article, we propose an advection-diffusion model for particle transport and investigate the dispersion process about the average particle current, which controls the separation... (More)

Deterministic lateral displacement provides a novel and efficient technique for sorting micrometer-sized particles based on particle size. It is grounded on the principle that the paths associated with particles of different diameters, entrained in flow streaming through a periodic lattice of obstacles, are characterized by different deflection angles with respect to the average direction of the carrier flow. Theoretical approaches have been developed, which predict quantitatively the dependence of the average deflection angle on particle size. In this article, we propose an advection-diffusion model for particle transport and investigate the dispersion process about the average particle current, which controls the separation resolution. We show that the interaction between deterministic and stochastic components of particle motion can give rise to enhanced effective dispersion regimes, which may hinder separation far beyond what could be anticipated from the value of the bare particle diffusivity. The large-scale effective diffusion process is typically non-isotropic and is represented by a symmetric second-order tensor whose principal axes are not collinear with the mainstream direction of the carrier flow, or with the average particle current. The enhanced dispersion regimes can be efficiently predicted by a tailored if unconventional implementation of Brenner's macrotransport paradigm, which amounts to solving a system of two elliptic PDEs on the minimal periodicity cell of the device. The impact of macrotransport parameter on separation resolution is addressed in the concrete case of cylindrical obstacles arranged along a square lattice. © 2013 Springer-Verlag Berlin Heidelberg.

(Less)
Please use this url to cite or link to this publication:
author
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Effective diffusivity, Fractionation, Lateral displacement, Macrotransport theory, Particle sorting, Periodic lattice
in
Microfluidics and Nanofluidics
volume
15
issue
4
pages
19 pages
publisher
Springer
external identifiers
  • Scopus:84885317905
ISSN
1613-4982
DOI
10.1007/s10404-013-1150-8
language
English
LU publication?
no
id
48e2d074-c7df-4cba-b103-56788733f49b
date added to LUP
2016-06-27 10:08:08
date last changed
2016-11-27 04:41:21
@misc{48e2d074-c7df-4cba-b103-56788733f49b,
  abstract     = {<p>Deterministic lateral displacement provides a novel and efficient technique for sorting micrometer-sized particles based on particle size. It is grounded on the principle that the paths associated with particles of different diameters, entrained in flow streaming through a periodic lattice of obstacles, are characterized by different deflection angles with respect to the average direction of the carrier flow. Theoretical approaches have been developed, which predict quantitatively the dependence of the average deflection angle on particle size. In this article, we propose an advection-diffusion model for particle transport and investigate the dispersion process about the average particle current, which controls the separation resolution. We show that the interaction between deterministic and stochastic components of particle motion can give rise to enhanced effective dispersion regimes, which may hinder separation far beyond what could be anticipated from the value of the bare particle diffusivity. The large-scale effective diffusion process is typically non-isotropic and is represented by a symmetric second-order tensor whose principal axes are not collinear with the mainstream direction of the carrier flow, or with the average particle current. The enhanced dispersion regimes can be efficiently predicted by a tailored if unconventional implementation of Brenner's macrotransport paradigm, which amounts to solving a system of two elliptic PDEs on the minimal periodicity cell of the device. The impact of macrotransport parameter on separation resolution is addressed in the concrete case of cylindrical obstacles arranged along a square lattice. © 2013 Springer-Verlag Berlin Heidelberg.</p>},
  author       = {Cerbelli, Stefano and Giona, Massimiliano and Garofalo, Fabio},
  issn         = {1613-4982},
  keyword      = {Effective diffusivity,Fractionation,Lateral displacement,Macrotransport theory,Particle sorting,Periodic lattice},
  language     = {eng},
  number       = {4},
  pages        = {431--449},
  publisher    = {ARRAY(0x944f960)},
  series       = {Microfluidics and Nanofluidics},
  title        = {Quantifying dispersion of finite-sized particles in deterministic lateral displacement microflow separators through Brenner's macrotransport paradigm},
  url          = {http://dx.doi.org/10.1007/s10404-013-1150-8},
  volume       = {15},
  year         = {2013},
}