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Familial Transmission of Hospital-Treated Varicose Veins in Adoptees : A Swedish Family Study

Kohno, Kunie; Niihara, Hiroyuki; Li, Xinjun LU ; Hamano, Tsuyoshi; Nabika, Toru; Shiwaku, Kuninori; Isomura, Minoru; Morita, Eishin; Sundquist, Kristina LU and Zöller, Bengt LU (2016) In Journal of the American College of Surgeons
Abstract

Background: Varicose veins (VVs) cluster in families, but the familial risk of VVs has not been determined among adoptees. The aim was to estimate whether the familial transmission of VVs is related to disease in biological and/or adoptive parents. Study Design: The Swedish Multi-Generation Register and the Swedish Patient Register were used to follow all Swedish-born adoptees (born 1932 through 2004) that could be linked to both their biological and their adoptive parents (n = 80,214; 50% females). The risk of VVs was estimated in adoptees with at least 1 biological parent with VVs, but no adoptive parent with VVs (n = 187) compared with adoptees without a biological or adoptive parent with VVs (n = 1,758). The risk of VVs was also... (More)

Background: Varicose veins (VVs) cluster in families, but the familial risk of VVs has not been determined among adoptees. The aim was to estimate whether the familial transmission of VVs is related to disease in biological and/or adoptive parents. Study Design: The Swedish Multi-Generation Register and the Swedish Patient Register were used to follow all Swedish-born adoptees (born 1932 through 2004) that could be linked to both their biological and their adoptive parents (n = 80,214; 50% females). The risk of VVs was estimated in adoptees with at least 1 biological parent with VVs, but no adoptive parent with VVs (n = 187) compared with adoptees without a biological or adoptive parent with VVs (n = 1,758). The risk of VVs was also determined in adoptees with at least 1 adoptive parent, but no biological parent with VVs (n = 87), and in adoptees with both biological and adoptive parents affected (n = 21). Results: Adoptees from an affected biological parent, but no adoptive parent, were more likely to have VVs than adoptees from an unaffected biological or adoptive parent (standard incidence ratio [SIR] = 2.21; 95% CI, 1.91-2.55). The familial SIR for adoptees with both an affected biological parent and an adoptive parent was 4.58 (95% CI, 2.83-7.01). Adoptees with an affected adoptive parent but no biological parent were not at increased risk of VVs (SIR = 1.15; 95% CI, 0.92-1.42). Conclusions: These novel findings suggest that genetic factors make a strong contribution to the familial transmission of VVs from parents to offspring, although familial environmental factors might contribute.

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author
organization
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Contribution to journal
publication status
in press
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Journal of the American College of Surgeons
publisher
Elsevier
external identifiers
  • Scopus:84979658067
ISSN
1072-7515
DOI
10.1016/j.jamcollsurg.2016.06.007
language
English
LU publication?
yes
id
4b213aeb-0f88-4544-93c4-855043cb31d2
date added to LUP
2016-09-08 15:56:49
date last changed
2016-09-20 03:02:25
@misc{4b213aeb-0f88-4544-93c4-855043cb31d2,
  abstract     = {<p>Background: Varicose veins (VVs) cluster in families, but the familial risk of VVs has not been determined among adoptees. The aim was to estimate whether the familial transmission of VVs is related to disease in biological and/or adoptive parents. Study Design: The Swedish Multi-Generation Register and the Swedish Patient Register were used to follow all Swedish-born adoptees (born 1932 through 2004) that could be linked to both their biological and their adoptive parents (n = 80,214; 50% females). The risk of VVs was estimated in adoptees with at least 1 biological parent with VVs, but no adoptive parent with VVs (n = 187) compared with adoptees without a biological or adoptive parent with VVs (n = 1,758). The risk of VVs was also determined in adoptees with at least 1 adoptive parent, but no biological parent with VVs (n = 87), and in adoptees with both biological and adoptive parents affected (n = 21). Results: Adoptees from an affected biological parent, but no adoptive parent, were more likely to have VVs than adoptees from an unaffected biological or adoptive parent (standard incidence ratio [SIR] = 2.21; 95% CI, 1.91-2.55). The familial SIR for adoptees with both an affected biological parent and an adoptive parent was 4.58 (95% CI, 2.83-7.01). Adoptees with an affected adoptive parent but no biological parent were not at increased risk of VVs (SIR = 1.15; 95% CI, 0.92-1.42). Conclusions: These novel findings suggest that genetic factors make a strong contribution to the familial transmission of VVs from parents to offspring, although familial environmental factors might contribute.</p>},
  author       = {Kohno, Kunie and Niihara, Hiroyuki and Li, Xinjun and Hamano, Tsuyoshi and Nabika, Toru and Shiwaku, Kuninori and Isomura, Minoru and Morita, Eishin and Sundquist, Kristina and Zöller, Bengt},
  issn         = {1072-7515},
  language     = {eng},
  month        = {03},
  publisher    = {ARRAY(0xaeb7ff8)},
  series       = {Journal of the American College of Surgeons},
  title        = {Familial Transmission of Hospital-Treated Varicose Veins in Adoptees : A Swedish Family Study},
  url          = {http://dx.doi.org/10.1016/j.jamcollsurg.2016.06.007},
  year         = {2016},
}