Advanced

Endarterectomy patients with elevated levels of circulating IL-16 have fewer cardiovascular events during follow-up

Grönberg, Caitríona LU ; Asciutto, Giuseppe LU ; Persson, Ana LU ; Fredrikson, Gunilla Nordin LU ; Nilsson, Jan LU ; Gonçalves, Isabel LU and Björkbacka, Harry LU (2016) In Cytokine 85. p.137-139
Abstract

Background and purpose Increased interleukin 16 (IL-16) levels in carotid plaques have been associated with reduced incidence of cardiovascular (CV) events during follow-up in patients who underwent carotid endarterectomy (CEA). In the present study we aimed to determine whether high circulating levels of IL-16 also are associated with a decreased risk of CV events after CEA. Methods Patients, who had their carotid plaques surgically removed (n = 473), were followed for a mean follow-up time of 3.1 years. Plasma levels of IL-16 the day before surgery were analyzed by proximity extension assay (PEA) and associated with the occurrence of CV events during follow-up (n = 98). Results High levels of circulating IL-16 were independently... (More)

Background and purpose Increased interleukin 16 (IL-16) levels in carotid plaques have been associated with reduced incidence of cardiovascular (CV) events during follow-up in patients who underwent carotid endarterectomy (CEA). In the present study we aimed to determine whether high circulating levels of IL-16 also are associated with a decreased risk of CV events after CEA. Methods Patients, who had their carotid plaques surgically removed (n = 473), were followed for a mean follow-up time of 3.1 years. Plasma levels of IL-16 the day before surgery were analyzed by proximity extension assay (PEA) and associated with the occurrence of CV events during follow-up (n = 98). Results High levels of circulating IL-16 were independently associated with a decreased risk of CV events when comparing the highest versus the lowest IL-16 tertile (hazard ratio [HR] 0.47; 95% CI 0.27–0.81; P = 0.007), as well as with CV deaths (HR 0.25; 95% CI 0.09–0.70; P = 0.008). Conclusion These present findings indicate an association between IL-16 and less clinical complications of atherosclerosis in a population with known advanced carotid disease.

(Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
epub
subject
keywords
Atherosclerosis, Cardiovascular events, Interleukin 16
in
Cytokine
volume
85
pages
3 pages
publisher
Academic Press
external identifiers
  • Scopus:84976318101
ISSN
1043-4666
DOI
10.1016/j.cyto.2016.06.009
language
English
LU publication?
yes
id
4f66f1de-1eb3-4e8f-a25e-1df909c54545
date added to LUP
2016-07-18 08:49:31
date last changed
2016-09-20 03:07:19
@misc{4f66f1de-1eb3-4e8f-a25e-1df909c54545,
  abstract     = {<p>Background and purpose Increased interleukin 16 (IL-16) levels in carotid plaques have been associated with reduced incidence of cardiovascular (CV) events during follow-up in patients who underwent carotid endarterectomy (CEA). In the present study we aimed to determine whether high circulating levels of IL-16 also are associated with a decreased risk of CV events after CEA. Methods Patients, who had their carotid plaques surgically removed (n = 473), were followed for a mean follow-up time of 3.1 years. Plasma levels of IL-16 the day before surgery were analyzed by proximity extension assay (PEA) and associated with the occurrence of CV events during follow-up (n = 98). Results High levels of circulating IL-16 were independently associated with a decreased risk of CV events when comparing the highest versus the lowest IL-16 tertile (hazard ratio [HR] 0.47; 95% CI 0.27–0.81; P = 0.007), as well as with CV deaths (HR 0.25; 95% CI 0.09–0.70; P = 0.008). Conclusion These present findings indicate an association between IL-16 and less clinical complications of atherosclerosis in a population with known advanced carotid disease.</p>},
  author       = {Grönberg, Caitríona and Asciutto, Giuseppe and Persson, Ana and Fredrikson, Gunilla Nordin and Nilsson, Jan and Gonçalves, Isabel and Björkbacka, Harry},
  issn         = {1043-4666},
  keyword      = {Atherosclerosis,Cardiovascular events,Interleukin 16},
  language     = {eng},
  month        = {09},
  pages        = {137--139},
  publisher    = {ARRAY(0x86add70)},
  series       = {Cytokine},
  title        = {Endarterectomy patients with elevated levels of circulating IL-16 have fewer cardiovascular events during follow-up},
  url          = {http://dx.doi.org/10.1016/j.cyto.2016.06.009},
  volume       = {85},
  year         = {2016},
}