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Epidemiological evaluation of cytogenetic biomarkers as potential surrogate end-points for cancer.

Hagmar, Lars; Strömberg, Ulf LU ; Tinnerberg, Håkan LU and Mikoczy, Zoli LU (2004) In Mechanisms of Carcinogenesis (IARC Sci. Publ. ; 157)
Abstract
Various occupational exposures have been monitored by chromosomal aberrations, sister chromatid exchanges and micronuclei in peripheral blood lymphocytes. During the last decade, epidemiological studies have evaluated whether any of these markers foreshadows cancer risk. Results from Nordic, Italian and Czech cohorts support an approximately twofold cancer risk among subjects with high frequencies of chromosomal aberrations, but no such association was seen for any of the other biomarkers. The estimated attributable proportion of high frequencies of chromosomal aberrations for overall cancer risk is 0.25, which gives a quantitative estimate of the chromosomal aberration assay as a surrogate endpoint of cancer. The results from the... (More)
Various occupational exposures have been monitored by chromosomal aberrations, sister chromatid exchanges and micronuclei in peripheral blood lymphocytes. During the last decade, epidemiological studies have evaluated whether any of these markers foreshadows cancer risk. Results from Nordic, Italian and Czech cohorts support an approximately twofold cancer risk among subjects with high frequencies of chromosomal aberrations, but no such association was seen for any of the other biomarkers. The estimated attributable proportion of high frequencies of chromosomal aberrations for overall cancer risk is 0.25, which gives a quantitative estimate of the chromosomal aberration assay as a surrogate endpoint of cancer. The results from the different cohort studies are contradictory in terms of whether or not the predictive value of the chromosomal aberration assay for cancer is differential with respect to occupational exposure to clastogens. Genetic susceptibility factors are known to affect the frequency of chromosomal aberrations in peripheral blood lymphocytes. It is quite possible that such factors might also affect the frequency of chromosomal aberrations directly or might modify the impact of exposures to clastogen. There is no other biomarker for general cancer risk that is applicable to healthy subjects from the general population with such a high attributable proportion. However, at present only a simplified and tentative model can be proposed for the role of the chromosomal aberration marker in the pathogenesis of cancer. (Less)
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author
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
keywords
Non-U.S. Gov't, Support, Neoplasms: genetics, Neoplasms: etiology, Biological Markers, Case-Control Studies, Chromosome Aberrations, Epidemiologic Studies, Human, Cohort Studies
in
Mechanisms of Carcinogenesis (IARC Sci. Publ. ; 157)
editor
Buffler, Patricia A; Rice, Jerry M; Baan, Robert; Bird, Michael G and Boffetta, Paolo
publisher
Oxford University Press
external identifiers
  • Scopus:1842862759
ISBN
92-832-2157-5
language
English
LU publication?
yes
id
7cf60012-4805-4bb7-ae41-d5c6408c804b (old id 526726)
date added to LUP
2007-09-13 21:54:00
date last changed
2016-10-13 04:45:21
@misc{7cf60012-4805-4bb7-ae41-d5c6408c804b,
  abstract     = {Various occupational exposures have been monitored by chromosomal aberrations, sister chromatid exchanges and micronuclei in peripheral blood lymphocytes. During the last decade, epidemiological studies have evaluated whether any of these markers foreshadows cancer risk. Results from Nordic, Italian and Czech cohorts support an approximately twofold cancer risk among subjects with high frequencies of chromosomal aberrations, but no such association was seen for any of the other biomarkers. The estimated attributable proportion of high frequencies of chromosomal aberrations for overall cancer risk is 0.25, which gives a quantitative estimate of the chromosomal aberration assay as a surrogate endpoint of cancer. The results from the different cohort studies are contradictory in terms of whether or not the predictive value of the chromosomal aberration assay for cancer is differential with respect to occupational exposure to clastogens. Genetic susceptibility factors are known to affect the frequency of chromosomal aberrations in peripheral blood lymphocytes. It is quite possible that such factors might also affect the frequency of chromosomal aberrations directly or might modify the impact of exposures to clastogen. There is no other biomarker for general cancer risk that is applicable to healthy subjects from the general population with such a high attributable proportion. However, at present only a simplified and tentative model can be proposed for the role of the chromosomal aberration marker in the pathogenesis of cancer.},
  author       = {Hagmar, Lars and Strömberg, Ulf and Tinnerberg, Håkan and Mikoczy, Zoli},
  editor       = {Buffler, Patricia A and Rice, Jerry M and Baan, Robert and Bird, Michael G and Boffetta, Paolo},
  isbn         = {92-832-2157-5},
  keyword      = {Non-U.S. Gov't,Support,Neoplasms: genetics,Neoplasms: etiology,Biological Markers,Case-Control Studies,Chromosome Aberrations,Epidemiologic Studies,Human,Cohort Studies},
  language     = {eng},
  publisher    = {ARRAY(0x998dc50)},
  series       = {Mechanisms of Carcinogenesis (IARC Sci. Publ. ; 157)},
  title        = {Epidemiological evaluation of cytogenetic biomarkers as potential surrogate end-points for cancer.},
  year         = {2004},
}