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Environmental cadmium and lead exposure and anti-Müllerian hormone in pregnant women

Christensen, P S; Bonde, J P; Bungum, L LU ; Giwercman, A LU ; Toft, G; Jönsson, Bo A LU and Specht, I O (2016) In Reproductive Toxicology 61. p.114-119
Abstract

BACKGROUND: Anti-Müllerian Hormone (AMH) has been suggested as a marker for ovarian function. Cadmium and lead have been suggested to reduce female fecundity. In this study we aimed to investigate whether environmental exposure to cadmium and lead was associated with alterations in serum-AMH.

MATERIALS AND METHOD: The associations between serum-AMH and whole blood cadmium or lead were investigated by general linear models in a population-based sample of 117 pregnant women.

RESULTS: The mean concentrations of blood cadmium and lead were 0.71μg/L and 17.4μg/L, respectively. The mean serum-AMH was 17.3pmol/L. No association between lead and AMH was detected. In the cadmium analysis the adjusted mean AMH level (95% CI) in the... (More)

BACKGROUND: Anti-Müllerian Hormone (AMH) has been suggested as a marker for ovarian function. Cadmium and lead have been suggested to reduce female fecundity. In this study we aimed to investigate whether environmental exposure to cadmium and lead was associated with alterations in serum-AMH.

MATERIALS AND METHOD: The associations between serum-AMH and whole blood cadmium or lead were investigated by general linear models in a population-based sample of 117 pregnant women.

RESULTS: The mean concentrations of blood cadmium and lead were 0.71μg/L and 17.4μg/L, respectively. The mean serum-AMH was 17.3pmol/L. No association between lead and AMH was detected. In the cadmium analysis the adjusted mean AMH level (95% CI) in the highest exposure tertile was 12.4 (6.4;23.8) compared to 5.6 (2.7;11.4) in the lowest exposure tertile (p=0.06).

CONCLUSION: The study provides suggestive evidence that environmental exposure to cadmium, but not lead, may alter the level of AMH.

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Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
epub
subject
in
Reproductive Toxicology
volume
61
pages
6 pages
publisher
Elsevier
external identifiers
  • Scopus:84962657017
ISSN
1873-1708
DOI
10.1016/j.reprotox.2016.03.047
language
English
LU publication?
yes
id
562c65f1-0d65-496c-b8b4-e447eb2d0b7c
date added to LUP
2016-04-28 13:27:34
date last changed
2016-10-27 12:53:49
@misc{562c65f1-0d65-496c-b8b4-e447eb2d0b7c,
  abstract     = {<p>BACKGROUND: Anti-Müllerian Hormone (AMH) has been suggested as a marker for ovarian function. Cadmium and lead have been suggested to reduce female fecundity. In this study we aimed to investigate whether environmental exposure to cadmium and lead was associated with alterations in serum-AMH.</p><p>MATERIALS AND METHOD: The associations between serum-AMH and whole blood cadmium or lead were investigated by general linear models in a population-based sample of 117 pregnant women.</p><p>RESULTS: The mean concentrations of blood cadmium and lead were 0.71μg/L and 17.4μg/L, respectively. The mean serum-AMH was 17.3pmol/L. No association between lead and AMH was detected. In the cadmium analysis the adjusted mean AMH level (95% CI) in the highest exposure tertile was 12.4 (6.4;23.8) compared to 5.6 (2.7;11.4) in the lowest exposure tertile (p=0.06).</p><p>CONCLUSION: The study provides suggestive evidence that environmental exposure to cadmium, but not lead, may alter the level of AMH.</p>},
  author       = {Christensen, P S and Bonde, J P and Bungum, L and Giwercman, A and Toft, G and Jönsson, Bo A and Specht, I O},
  issn         = {1873-1708},
  language     = {eng},
  month        = {04},
  pages        = {114--119},
  publisher    = {ARRAY(0xcef1728)},
  series       = {Reproductive Toxicology},
  title        = {Environmental cadmium and lead exposure and anti-Müllerian hormone in pregnant women},
  url          = {http://dx.doi.org/10.1016/j.reprotox.2016.03.047},
  volume       = {61},
  year         = {2016},
}