Advanced

Acute cobalt exposure and oxygen radical scavengers in the rat myocardium

Hatori, Nobuo; Pehrsson, Kenneth; Clyne, Naomi LU ; Hansson, Göran; Hofman-Bang, Claes; Marklund, Stefan L.; Rydén, Lars; Sjöqvist, Per Ove and Svensso, Lennart (1993) In Biochimica et Biophysica Acta - Molecular Basis of Disease 1181(3). p.257-260
Abstract

Excessive amounts of cobalt are cardiotoxic, although the mechanism for this toxicity remains unclear. We studied the effects of acute cobalt exposure on the activities of free radical scavengers in the myocardium in 5 groups of rats. Six rats served as a control group and were given a daily subcutaneous injection of 1 ml saline for 8 days. The other 4 groups of rats received a daily injection subcutaneously of cobalt chloride in doses of 1 mg/kg bw, 5 mg/kg bw, 20 mg/kg bw and 50 mg/kg bw, respectively for 8 days. There was a marked and dose-dependent accumulation of cobalt in the myocardium of the cobalt exposed rats. Creatine kinase, copper-zinc superoxide dismutase (CuZn-SOD) and α-tocopherol content did not differ between the... (More)

Excessive amounts of cobalt are cardiotoxic, although the mechanism for this toxicity remains unclear. We studied the effects of acute cobalt exposure on the activities of free radical scavengers in the myocardium in 5 groups of rats. Six rats served as a control group and were given a daily subcutaneous injection of 1 ml saline for 8 days. The other 4 groups of rats received a daily injection subcutaneously of cobalt chloride in doses of 1 mg/kg bw, 5 mg/kg bw, 20 mg/kg bw and 50 mg/kg bw, respectively for 8 days. There was a marked and dose-dependent accumulation of cobalt in the myocardium of the cobalt exposed rats. Creatine kinase, copper-zinc superoxide dismutase (CuZn-SOD) and α-tocopherol content did not differ between the control and the cobalt exposed groups. The activity of glutathione peroxidase increased, while the activity of manganese-superoxide dismutase (Mn-SOD) was significantly reduced in the cobalt exposed groups. There was an inverse relationship (r = 0.60, P

(Less)
Please use this url to cite or link to this publication:
author
publishing date
type
Contribution to journal
publication status
published
keywords
Cobalt, Glutathione peroxidase, Superoxide dismutase, α-Tocopherol
in
Biochimica et Biophysica Acta - Molecular Basis of Disease
volume
1181
issue
3
pages
4 pages
publisher
Elsevier
external identifiers
  • Scopus:0027190724
ISSN
0925-4439
DOI
10.1016/0925-4439(93)90029-Z
language
English
LU publication?
no
id
575760ca-7634-4cec-bc6c-cdd0923302d6
date added to LUP
2016-08-30 22:04:30
date last changed
2016-09-16 15:09:50
@misc{575760ca-7634-4cec-bc6c-cdd0923302d6,
  abstract     = {<p>Excessive amounts of cobalt are cardiotoxic, although the mechanism for this toxicity remains unclear. We studied the effects of acute cobalt exposure on the activities of free radical scavengers in the myocardium in 5 groups of rats. Six rats served as a control group and were given a daily subcutaneous injection of 1 ml saline for 8 days. The other 4 groups of rats received a daily injection subcutaneously of cobalt chloride in doses of 1 mg/kg bw, 5 mg/kg bw, 20 mg/kg bw and 50 mg/kg bw, respectively for 8 days. There was a marked and dose-dependent accumulation of cobalt in the myocardium of the cobalt exposed rats. Creatine kinase, copper-zinc superoxide dismutase (CuZn-SOD) and α-tocopherol content did not differ between the control and the cobalt exposed groups. The activity of glutathione peroxidase increased, while the activity of manganese-superoxide dismutase (Mn-SOD) was significantly reduced in the cobalt exposed groups. There was an inverse relationship (r = 0.60, P </p>},
  author       = {Hatori, Nobuo and Pehrsson, Kenneth and Clyne, Naomi and Hansson, Göran and Hofman-Bang, Claes and Marklund, Stefan L. and Rydén, Lars and Sjöqvist, Per Ove and Svensso, Lennart},
  issn         = {0925-4439},
  keyword      = {Cobalt,Glutathione peroxidase,Superoxide dismutase,α-Tocopherol},
  language     = {eng},
  month        = {06},
  number       = {3},
  pages        = {257--260},
  publisher    = {ARRAY(0xbc589d8)},
  series       = {Biochimica et Biophysica Acta - Molecular Basis of Disease},
  title        = {Acute cobalt exposure and oxygen radical scavengers in the rat myocardium},
  url          = {http://dx.doi.org/10.1016/0925-4439(93)90029-Z},
  volume       = {1181},
  year         = {1993},
}