Acute cobalt exposure and oxygen radical scavengers in the rat myocardium
Hatori, Nobuo ; Pehrsson, Kenneth ; Clyne, Naomi LU
; Hansson, Göran
; Hofman-Bang, Claes
; Marklund, Stefan L.
; Rydén, Lars
; Sjöqvist, Per Ove
and Svensso, Lennart
(1993)
In Biochimica et Biophysica Acta - Molecular Basis of Disease
1181(3).
p.257-260
- Abstract
Excessive amounts of cobalt are cardiotoxic, although the mechanism for this toxicity remains unclear. We studied the effects of acute cobalt exposure on the activities of free radical scavengers in the myocardium in 5 groups of rats. Six rats served as a control group and were given a daily subcutaneous injection of 1 ml saline for 8 days. The other 4 groups of rats received a daily injection subcutaneously of cobalt chloride in doses of 1 mg/kg bw, 5 mg/kg bw, 20 mg/kg bw and 50 mg/kg bw, respectively for 8 days. There was a marked and dose-dependent accumulation of cobalt in the myocardium of the cobalt exposed rats. Creatine kinase, copper-zinc superoxide dismutase (CuZn-SOD) and α-tocopherol content did not differ between the... (More)
Excessive amounts of cobalt are cardiotoxic, although the mechanism for this toxicity remains unclear. We studied the effects of acute cobalt exposure on the activities of free radical scavengers in the myocardium in 5 groups of rats. Six rats served as a control group and were given a daily subcutaneous injection of 1 ml saline for 8 days. The other 4 groups of rats received a daily injection subcutaneously of cobalt chloride in doses of 1 mg/kg bw, 5 mg/kg bw, 20 mg/kg bw and 50 mg/kg bw, respectively for 8 days. There was a marked and dose-dependent accumulation of cobalt in the myocardium of the cobalt exposed rats. Creatine kinase, copper-zinc superoxide dismutase (CuZn-SOD) and α-tocopherol content did not differ between the control and the cobalt exposed groups. The activity of glutathione peroxidase increased, while the activity of manganese-superoxide dismutase (Mn-SOD) was significantly reduced in the cobalt exposed groups. There was an inverse relationship (r = 0.60, P
(Less)
- author
- Hatori, Nobuo
; Pehrsson, Kenneth
; Clyne, Naomi
LU
; Hansson, Göran
; Hofman-Bang, Claes
; Marklund, Stefan L.
; Rydén, Lars
; Sjöqvist, Per Ove
and Svensso, Lennart
- publishing date
- 1993-06-19
- type
- Contribution to journal
- publication status
- published
- keywords
- Cobalt, Glutathione peroxidase, Superoxide dismutase, α-Tocopherol
- in
- Biochimica et Biophysica Acta - Molecular Basis of Disease
- volume
- 1181
- issue
- 3
- pages
- 4 pages
- publisher
- Elsevier
- external identifiers
-
- pmid:8391326
- scopus:0027190724
- ISSN
- 0925-4439
- DOI
- 10.1016/0925-4439(93)90029-Z
- language
- English
- LU publication?
- no
- id
- 575760ca-7634-4cec-bc6c-cdd0923302d6
- date added to LUP
- 2016-08-30 22:04:30
- date last changed
- 2024-04-19 08:57:08
@article{575760ca-7634-4cec-bc6c-cdd0923302d6,
abstract = {{<p>Excessive amounts of cobalt are cardiotoxic, although the mechanism for this toxicity remains unclear. We studied the effects of acute cobalt exposure on the activities of free radical scavengers in the myocardium in 5 groups of rats. Six rats served as a control group and were given a daily subcutaneous injection of 1 ml saline for 8 days. The other 4 groups of rats received a daily injection subcutaneously of cobalt chloride in doses of 1 mg/kg bw, 5 mg/kg bw, 20 mg/kg bw and 50 mg/kg bw, respectively for 8 days. There was a marked and dose-dependent accumulation of cobalt in the myocardium of the cobalt exposed rats. Creatine kinase, copper-zinc superoxide dismutase (CuZn-SOD) and α-tocopherol content did not differ between the control and the cobalt exposed groups. The activity of glutathione peroxidase increased, while the activity of manganese-superoxide dismutase (Mn-SOD) was significantly reduced in the cobalt exposed groups. There was an inverse relationship (r = 0.60, P </p>}},
author = {{Hatori, Nobuo and Pehrsson, Kenneth and Clyne, Naomi and Hansson, Göran and Hofman-Bang, Claes and Marklund, Stefan L. and Rydén, Lars and Sjöqvist, Per Ove and Svensso, Lennart}},
issn = {{0925-4439}},
keywords = {{Cobalt; Glutathione peroxidase; Superoxide dismutase; α-Tocopherol}},
language = {{eng}},
month = {{06}},
number = {{3}},
pages = {{257--260}},
publisher = {{Elsevier}},
series = {{Biochimica et Biophysica Acta - Molecular Basis of Disease}},
title = {{Acute cobalt exposure and oxygen radical scavengers in the rat myocardium}},
url = {{http://dx.doi.org/10.1016/0925-4439(93)90029-Z}},
doi = {{10.1016/0925-4439(93)90029-Z}},
volume = {{1181}},
year = {{1993}},
}