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A new mouse model that spontaneously develops chronic liver inflammation and fibrosis

Fransén-Pettersson, Nina LU ; Duarte, Nadia; Nilsson, Julia LU ; Lundholm, Marie; Mayans, Sofia; Larefalk, Åsa; Hannibal, Tine D. LU ; Hansen, Lisbeth LU ; Schmidt-Christensen, Anja LU and Ivars, Fredrik LU , et al. (2016) In PLoS One 11(7).
Abstract

Here we characterize a new animal model that spontaneously develops chronic inflammation and fibrosis in multiple organs, the non-obese diabetic inflammation and fibrosis (N-IF) mouse. In the liver, the N-IF mouse displays inflammation and fibrosis particularly evident around portal tracts and central veins and accompanied with evidence of abnormal intrahepatic bile ducts. The extensive cellular infiltration consists mainly of macrophages, granulocytes, particularly eosinophils, and mast cells. This inflammatory syndrome is mediated by a transgenic population of natural killer T cells (NKT) induced in an immunodeficient NOD genetic background. The disease is transferrable to immunodeficient recipients, while polyclonal T cells from... (More)

Here we characterize a new animal model that spontaneously develops chronic inflammation and fibrosis in multiple organs, the non-obese diabetic inflammation and fibrosis (N-IF) mouse. In the liver, the N-IF mouse displays inflammation and fibrosis particularly evident around portal tracts and central veins and accompanied with evidence of abnormal intrahepatic bile ducts. The extensive cellular infiltration consists mainly of macrophages, granulocytes, particularly eosinophils, and mast cells. This inflammatory syndrome is mediated by a transgenic population of natural killer T cells (NKT) induced in an immunodeficient NOD genetic background. The disease is transferrable to immunodeficient recipients, while polyclonal T cells from unaffected syngeneic donors can inhibit the disease phenotype. Because of the fibrotic component, early on-set, spontaneous nature and reproducibility, this novel mouse model provides a unique tool to gain further insight into the underlying mechanisms mediating transformation of chronic inflammation into fibrosis and to evaluate intervention protocols for treating conditions of fibrotic disorders.

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PLoS One
volume
11
issue
7
publisher
Public Library of Science
external identifiers
  • Scopus:84979599716
ISSN
1932-6203
DOI
10.1371/journal.pone.0159850
language
English
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yes
id
5920ec03-f7f8-472a-a2f2-b83d3c72095b
date added to LUP
2016-09-08 14:52:27
date last changed
2016-10-28 12:35:02
@misc{5920ec03-f7f8-472a-a2f2-b83d3c72095b,
  abstract     = {<p>Here we characterize a new animal model that spontaneously develops chronic inflammation and fibrosis in multiple organs, the non-obese diabetic inflammation and fibrosis (N-IF) mouse. In the liver, the N-IF mouse displays inflammation and fibrosis particularly evident around portal tracts and central veins and accompanied with evidence of abnormal intrahepatic bile ducts. The extensive cellular infiltration consists mainly of macrophages, granulocytes, particularly eosinophils, and mast cells. This inflammatory syndrome is mediated by a transgenic population of natural killer T cells (NKT) induced in an immunodeficient NOD genetic background. The disease is transferrable to immunodeficient recipients, while polyclonal T cells from unaffected syngeneic donors can inhibit the disease phenotype. Because of the fibrotic component, early on-set, spontaneous nature and reproducibility, this novel mouse model provides a unique tool to gain further insight into the underlying mechanisms mediating transformation of chronic inflammation into fibrosis and to evaluate intervention protocols for treating conditions of fibrotic disorders.</p>},
  author       = {Fransén-Pettersson, Nina and Duarte, Nadia and Nilsson, Julia and Lundholm, Marie and Mayans, Sofia and Larefalk, Åsa and Hannibal, Tine D. and Hansen, Lisbeth and Schmidt-Christensen, Anja and Ivars, Fredrik and Cardell, Susanna and Palmqvist, Richard and Rozell, Björn and Holmberg, Dan},
  issn         = {1932-6203},
  language     = {eng},
  month        = {07},
  number       = {7},
  publisher    = {ARRAY(0x8769190)},
  series       = {PLoS One},
  title        = {A new mouse model that spontaneously develops chronic liver inflammation and fibrosis},
  url          = {http://dx.doi.org/10.1371/journal.pone.0159850},
  volume       = {11},
  year         = {2016},
}