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CD40 expression identifies a prognostically favourable subgroup of diffuse large B-cell lymphoma.

Linderoth, Johan LU ; Ehinger, Mats LU ; Jerkeman, Mats LU ; Bendahl, Pär-Ola LU ; Åkerman, Måns LU ; Berglund, Mattias; Enblad, Gunilla; Erlanson, Martin; Roos, Goran and Cavallin-Ståhl, Eva LU (2007) In Leukemia & Lymphoma 48(9). p.1774-1779
Abstract
In order to confirm our earlier findings of the prognostic effects of CD23 and CD40 expression in diffuse large B-cell lymphoma (DLBCL), possibly due to association with the germinal center (GC) phenotype and/or an increased autologous tumour response, tumour specimens from 125 patients with de novo DLBCL were investigated for immunohistochemical expression of CD23, CD40, BCL6, CD10, MUM1, CD4 and CD8. CD40 was positive in 64% and was associated with improved overall survival (p = 0.03). A GC phenotype was present in 47%, and was also associated with a better overall survival (p = 0.006) but did not correlate with CD40-expression. There was no correlation between amount of tumour infiltrating T-cells and CD40-positivity. CD23 was positive... (More)
In order to confirm our earlier findings of the prognostic effects of CD23 and CD40 expression in diffuse large B-cell lymphoma (DLBCL), possibly due to association with the germinal center (GC) phenotype and/or an increased autologous tumour response, tumour specimens from 125 patients with de novo DLBCL were investigated for immunohistochemical expression of CD23, CD40, BCL6, CD10, MUM1, CD4 and CD8. CD40 was positive in 64% and was associated with improved overall survival (p = 0.03). A GC phenotype was present in 47%, and was also associated with a better overall survival (p = 0.006) but did not correlate with CD40-expression. There was no correlation between amount of tumour infiltrating T-cells and CD40-positivity. CD23 was positive in 10% and expression did not correlate with prognosis. In conclusion, the prognostic effect of CD40 expression was confirmed, but did not correlate with GC-phenotype or T-cell infiltration. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
DLBCL, CD40, prognosis, GC-phenotype, CD4, CD8
in
Leukemia & Lymphoma
volume
48
issue
9
pages
1774 - 1779
publisher
Taylor & Francis
external identifiers
  • WOS:000249764200016
  • Scopus:34548593571
ISSN
1042-8194
DOI
10.1080/10428190701494520
language
English
LU publication?
yes
id
7a7bd001-5f3c-419f-9a39-d4eca993a86c (old id 607952)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17786713&dopt=Abstract
date added to LUP
2007-12-13 11:46:08
date last changed
2016-11-14 11:11:53
@misc{7a7bd001-5f3c-419f-9a39-d4eca993a86c,
  abstract     = {In order to confirm our earlier findings of the prognostic effects of CD23 and CD40 expression in diffuse large B-cell lymphoma (DLBCL), possibly due to association with the germinal center (GC) phenotype and/or an increased autologous tumour response, tumour specimens from 125 patients with de novo DLBCL were investigated for immunohistochemical expression of CD23, CD40, BCL6, CD10, MUM1, CD4 and CD8. CD40 was positive in 64% and was associated with improved overall survival (p = 0.03). A GC phenotype was present in 47%, and was also associated with a better overall survival (p = 0.006) but did not correlate with CD40-expression. There was no correlation between amount of tumour infiltrating T-cells and CD40-positivity. CD23 was positive in 10% and expression did not correlate with prognosis. In conclusion, the prognostic effect of CD40 expression was confirmed, but did not correlate with GC-phenotype or T-cell infiltration.},
  author       = {Linderoth, Johan and Ehinger, Mats and Jerkeman, Mats and Bendahl, Pär-Ola and Åkerman, Måns and Berglund, Mattias and Enblad, Gunilla and Erlanson, Martin and Roos, Goran and Cavallin-Ståhl, Eva},
  issn         = {1042-8194},
  keyword      = {DLBCL,CD40,prognosis,GC-phenotype,CD4,CD8},
  language     = {eng},
  number       = {9},
  pages        = {1774--1779},
  publisher    = {ARRAY(0xbc647f0)},
  series       = {Leukemia & Lymphoma},
  title        = {CD40 expression identifies a prognostically favourable subgroup of diffuse large B-cell lymphoma.},
  url          = {http://dx.doi.org/10.1080/10428190701494520},
  volume       = {48},
  year         = {2007},
}