Advanced

Fructose-induced carbonyl/oxidative stress in S. Cerevisiae : Involvement of TOR

Valishkevych, Bohdana V.; Vasylkovska, Ruslana A.; Lozinska, Liudmyla M. LU and Semchyshyn, Halyna M. (2016) In Biochemistry Research International 2016.
Abstract

The TOR (target of rapamycin) signaling pathway first described in the budding yeast Saccharomyces cerevisiae is highly conserved in eukaryotes effector of cell growth, longevity, and stress response. TOR activation by nitrogen sources, in particular amino acids, is well studied; however its interplay with carbohydrates and carbonyl stress is poorly investigated. Fructose is a more potent glycoxidation agent capable of producing greater amounts of reactive carbonyl (RCS) and oxygen species (ROS) than glucose. The increased RCS/ROS production, as a result of glycoxidation in vivo, is supposed to be involved in carbonyl/oxidative stress, metabolic disorders, and lifespan shortening of eukaryotes. In this work we aim to expand our... (More)

The TOR (target of rapamycin) signaling pathway first described in the budding yeast Saccharomyces cerevisiae is highly conserved in eukaryotes effector of cell growth, longevity, and stress response. TOR activation by nitrogen sources, in particular amino acids, is well studied; however its interplay with carbohydrates and carbonyl stress is poorly investigated. Fructose is a more potent glycoxidation agent capable of producing greater amounts of reactive carbonyl (RCS) and oxygen species (ROS) than glucose. The increased RCS/ROS production, as a result of glycoxidation in vivo, is supposed to be involved in carbonyl/oxidative stress, metabolic disorders, and lifespan shortening of eukaryotes. In this work we aim to expand our understanding of how TOR is involved in carbonyl/oxidative stress caused by reducing monosaccharides. It was found that in fructose-grown compared with glucose-grown cells the level of carbonyl/oxidative stress markers was higher. The defects in the TOR pathway inhibited metabolic rate and suppressed generation of glycoxidation products in fructose-grown yeast.

(Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Biochemistry Research International
volume
2016
publisher
Hindawi Publishing Corporation
external identifiers
  • Scopus:84960976690
ISSN
2090-2247
DOI
10.1155/2016/8917270
language
English
LU publication?
yes
id
60fd3f60-32c7-4047-9a29-a0d7b9bd9b1c
date added to LUP
2016-09-21 10:06:37
date last changed
2016-09-22 03:00:05
@misc{60fd3f60-32c7-4047-9a29-a0d7b9bd9b1c,
  abstract     = {<p>The TOR (target of rapamycin) signaling pathway first described in the budding yeast Saccharomyces cerevisiae is highly conserved in eukaryotes effector of cell growth, longevity, and stress response. TOR activation by nitrogen sources, in particular amino acids, is well studied; however its interplay with carbohydrates and carbonyl stress is poorly investigated. Fructose is a more potent glycoxidation agent capable of producing greater amounts of reactive carbonyl (RCS) and oxygen species (ROS) than glucose. The increased RCS/ROS production, as a result of glycoxidation in vivo, is supposed to be involved in carbonyl/oxidative stress, metabolic disorders, and lifespan shortening of eukaryotes. In this work we aim to expand our understanding of how TOR is involved in carbonyl/oxidative stress caused by reducing monosaccharides. It was found that in fructose-grown compared with glucose-grown cells the level of carbonyl/oxidative stress markers was higher. The defects in the TOR pathway inhibited metabolic rate and suppressed generation of glycoxidation products in fructose-grown yeast.</p>},
  author       = {Valishkevych, Bohdana V. and Vasylkovska, Ruslana A. and Lozinska, Liudmyla M. and Semchyshyn, Halyna M.},
  issn         = {2090-2247},
  language     = {eng},
  publisher    = {ARRAY(0x8faa0e8)},
  series       = {Biochemistry Research International},
  title        = {Fructose-induced carbonyl/oxidative stress in S. Cerevisiae : Involvement of TOR},
  url          = {http://dx.doi.org/10.1155/2016/8917270},
  volume       = {2016},
  year         = {2016},
}