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Computational design of protein self-assembly

Norn, Christoffer H. LU and André, Ingemar LU (2016) In Current Opinion in Structural Biology 39. p.39-45
Abstract

Protein self-assembly is extensively used in nature to build functional biomolecules and provides a general approach to design molecular complexes with many intriguing applications. Although computational design of protein-protein interfaces remains difficult, much progress has recently been made in de novo design of protein assemblies with cyclic, helical, cubic, internal and lattice symmetries. Here, we discuss some of the underlying biophysical principles of self-assembly that influence the design problem and highlight methodological advances that have made self-assembly design a fruitful area of protein design.

Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Current Opinion in Structural Biology
volume
39
pages
7 pages
publisher
Elsevier
external identifiers
  • Scopus:84973131364
ISSN
0959-440X
DOI
10.1016/j.sbi.2016.04.002
language
English
LU publication?
yes
id
638ab7fc-58f8-485b-bdf2-1c55f8f9e947
date added to LUP
2016-06-23 07:40:44
date last changed
2016-09-20 03:19:33
@misc{638ab7fc-58f8-485b-bdf2-1c55f8f9e947,
  abstract     = {<p>Protein self-assembly is extensively used in nature to build functional biomolecules and provides a general approach to design molecular complexes with many intriguing applications. Although computational design of protein-protein interfaces remains difficult, much progress has recently been made in de novo design of protein assemblies with cyclic, helical, cubic, internal and lattice symmetries. Here, we discuss some of the underlying biophysical principles of self-assembly that influence the design problem and highlight methodological advances that have made self-assembly design a fruitful area of protein design.</p>},
  author       = {Norn, Christoffer H. and André, Ingemar},
  issn         = {0959-440X},
  language     = {eng},
  month        = {08},
  pages        = {39--45},
  publisher    = {ARRAY(0x9d32168)},
  series       = {Current Opinion in Structural Biology},
  title        = {Computational design of protein self-assembly},
  url          = {http://dx.doi.org/10.1016/j.sbi.2016.04.002},
  volume       = {39},
  year         = {2016},
}