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Defining the role of molecular markers to monitor disease, intervention, and cartilage breakdown in osteoarthritis

Lohmander, L. Stefan LU and Felson, David T. (1997) In Journal of Rheumatology 24(4). p.782-785
Abstract

Osteoarthritis (OA) is associated with a loss of the normal balance between synthesis and degradation of the macromolecules that provide articular cartilage with its biomechanical and functional properties. The destruction of joint cartilage involves the degradation of matrix molecules which are released as fragments to joint fluid, blood, and urine, where they may be detected, for example, by immunoassay. It has been suggested that such molecular markers of cartilage matrix metabolism could be used as markers to determine diagnosis, prognosis, and severity, to predict response to therapy and monitor response to therapy, and to identify disease mechanisms on the molecular level. Since markers reflect ongoing dynamic changes in joints,... (More)

Osteoarthritis (OA) is associated with a loss of the normal balance between synthesis and degradation of the macromolecules that provide articular cartilage with its biomechanical and functional properties. The destruction of joint cartilage involves the degradation of matrix molecules which are released as fragments to joint fluid, blood, and urine, where they may be detected, for example, by immunoassay. It has been suggested that such molecular markers of cartilage matrix metabolism could be used as markers to determine diagnosis, prognosis, and severity, to predict response to therapy and monitor response to therapy, and to identify disease mechanisms on the molecular level. Since markers reflect ongoing dynamic changes in joints, they are perhaps most likely to serve as measures of prognosis and measures of response to treatment. Some markers may serve multiple functions. To function as adequate tests, they should meet a set of standards. It is only when markers have met such criteria that they will be accepted in the research and clinical community and will become widely used.

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Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Cartilage, Diagnosis, Osteoarthritis, Reproducibility of results
in
Journal of Rheumatology
volume
24
issue
4
pages
4 pages
publisher
J Rheumatol Publ Co
external identifiers
  • Scopus:0030953586
ISSN
0315-162X
language
English
LU publication?
yes
id
6512b6ea-bd71-473f-a947-9d283df90fcd
date added to LUP
2016-05-04 23:55:56
date last changed
2016-08-04 12:33:54
@misc{6512b6ea-bd71-473f-a947-9d283df90fcd,
  abstract     = {<p>Osteoarthritis (OA) is associated with a loss of the normal balance between synthesis and degradation of the macromolecules that provide articular cartilage with its biomechanical and functional properties. The destruction of joint cartilage involves the degradation of matrix molecules which are released as fragments to joint fluid, blood, and urine, where they may be detected, for example, by immunoassay. It has been suggested that such molecular markers of cartilage matrix metabolism could be used as markers to determine diagnosis, prognosis, and severity, to predict response to therapy and monitor response to therapy, and to identify disease mechanisms on the molecular level. Since markers reflect ongoing dynamic changes in joints, they are perhaps most likely to serve as measures of prognosis and measures of response to treatment. Some markers may serve multiple functions. To function as adequate tests, they should meet a set of standards. It is only when markers have met such criteria that they will be accepted in the research and clinical community and will become widely used.</p>},
  author       = {Lohmander, L. Stefan and Felson, David T.},
  issn         = {0315-162X},
  keyword      = {Cartilage,Diagnosis,Osteoarthritis,Reproducibility of results},
  language     = {eng},
  number       = {4},
  pages        = {782--785},
  publisher    = {ARRAY(0x9746dd0)},
  series       = {Journal of Rheumatology},
  title        = {Defining the role of molecular markers to monitor disease, intervention, and cartilage breakdown in osteoarthritis},
  volume       = {24},
  year         = {1997},
}