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Distribution of the secretory leucocyte proteinase inhibitor in human articular cartilage

Ohlsson, S LU ; Tufvesson, B; Polling, A and Ohlsson, K LU (1997) In Biological Chemistry 378(9). p.8-1055
Abstract

The secretory leucocyte protease inhibitor, SLPI, is a low molecular weight inhibitor of proteases such as elastase and cathepsin G, which are released from leucocytes during phagocytosis. The purpose of this study was to show whether or not SLPI is produced in articular chondrocytes. In articular disorders, the protease-antiprotease balance is disturbed. For this reason it would be interesting to establish the source of SLPI. The presence of SLPI was demonstrated using immunohistochemistry and in situ hybridization, hence we conclude that SLPI is produced in the chondrocytes of human articular cartilage.

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author
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Arthroplasty, Replacement, Hip, Arthroplasty, Replacement, Knee, Cartilage, Articular, Chondrocytes, Humans, Immunohistochemistry, In Situ Hybridization, Membrane Proteins, Oligonucleotide Probes, Proteinase Inhibitory Proteins, Secretory, Proteins, Secretory Leukocyte Peptidase Inhibitor, Serine Proteinase Inhibitors, Journal Article, Research Support, Non-U.S. Gov't
in
Biological Chemistry
volume
378
issue
9
pages
4 pages
publisher
De Gruyter
external identifiers
  • Scopus:0030771751
ISSN
1431-6730
language
English
LU publication?
no
id
673213de-6dc4-4a32-9328-781c2685799d
date added to LUP
2016-09-19 10:44:33
date last changed
2016-11-28 14:32:46
@misc{673213de-6dc4-4a32-9328-781c2685799d,
  abstract     = {<p>The secretory leucocyte protease inhibitor, SLPI, is a low molecular weight inhibitor of proteases such as elastase and cathepsin G, which are released from leucocytes during phagocytosis. The purpose of this study was to show whether or not SLPI is produced in articular chondrocytes. In articular disorders, the protease-antiprotease balance is disturbed. For this reason it would be interesting to establish the source of SLPI. The presence of SLPI was demonstrated using immunohistochemistry and in situ hybridization, hence we conclude that SLPI is produced in the chondrocytes of human articular cartilage.</p>},
  author       = {Ohlsson, S and Tufvesson, B and Polling, A and Ohlsson, K},
  issn         = {1431-6730},
  keyword      = {Arthroplasty, Replacement, Hip,Arthroplasty, Replacement, Knee,Cartilage, Articular,Chondrocytes,Humans,Immunohistochemistry,In Situ Hybridization,Membrane Proteins,Oligonucleotide Probes,Proteinase Inhibitory Proteins, Secretory,Proteins,Secretory Leukocyte Peptidase Inhibitor,Serine Proteinase Inhibitors,Journal Article,Research Support, Non-U.S. Gov't},
  language     = {eng},
  number       = {9},
  pages        = {8--1055},
  publisher    = {ARRAY(0xd171498)},
  series       = {Biological Chemistry},
  title        = {Distribution of the secretory leucocyte proteinase inhibitor in human articular cartilage},
  volume       = {378},
  year         = {1997},
}