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Cartilage oligomeric matrix protein. A novel marker of cartilage turnover detectable in synovial fluid and blood

Saxne, Tore LU and Heinegård, Dick LU (1992) In British Journal of Rheumatology 31(9). p.583-591
Abstract
Cartilage oligomeric matrix protein (COMP) is a tissue specific non-collagenous matrix protein. We have developed an enzyme-linked immunosorbent assay for the detection of this protein in synovial fluid and serum. The protein has been quantified in these fluids in patients with rheumatoid arthritis (RA), reactive arthritis, juvenile chronic arthritis, osteoarthritis and in sera of control subjects. The protein was detectable in all fluids and the synovial fluid levels were always higher than in serum in paired samples. The highest knee joint synovial fluid levels were found in reactive arthritis patients and the lowest in RA patients with advanced destruction of the knee joint. However, the relative synovial fluid content of COMP was... (More)
Cartilage oligomeric matrix protein (COMP) is a tissue specific non-collagenous matrix protein. We have developed an enzyme-linked immunosorbent assay for the detection of this protein in synovial fluid and serum. The protein has been quantified in these fluids in patients with rheumatoid arthritis (RA), reactive arthritis, juvenile chronic arthritis, osteoarthritis and in sera of control subjects. The protein was detectable in all fluids and the synovial fluid levels were always higher than in serum in paired samples. The highest knee joint synovial fluid levels were found in reactive arthritis patients and the lowest in RA patients with advanced destruction of the knee joint. However, the relative synovial fluid content of COMP was higher in these RA patients than in patients with advanced osteoarthritis. In patients with long-standing reactive synovitis the concentrations decreased. This decrease, however, was less marked than for proteoglycan concentrations. The serum concentrations were low in patients with juvenile chronic arthritis and in patients with RA with advanced cartilage destruction of the studied knee joint. In the other groups serum levels did not differ between groups or from controls. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Arthritis/blood, Proteoglycans/blood, Synovial Fluid/metabolism
in
British Journal of Rheumatology
volume
31
issue
9
pages
583 - 591
publisher
Oxford University Press
external identifiers
  • Scopus:0026660250
language
English
LU publication?
yes
id
73b2e84c-36a9-4328-ab90-a570c0f68c3c
date added to LUP
2016-05-07 09:46:25
date last changed
2016-11-06 04:37:41
@misc{73b2e84c-36a9-4328-ab90-a570c0f68c3c,
  abstract     = {Cartilage oligomeric matrix protein (COMP) is a tissue specific non-collagenous matrix protein. We have developed an enzyme-linked immunosorbent assay for the detection of this protein in synovial fluid and serum. The protein has been quantified in these fluids in patients with rheumatoid arthritis (RA), reactive arthritis, juvenile chronic arthritis, osteoarthritis and in sera of control subjects. The protein was detectable in all fluids and the synovial fluid levels were always higher than in serum in paired samples. The highest knee joint synovial fluid levels were found in reactive arthritis patients and the lowest in RA patients with advanced destruction of the knee joint. However, the relative synovial fluid content of COMP was higher in these RA patients than in patients with advanced osteoarthritis. In patients with long-standing reactive synovitis the concentrations decreased. This decrease, however, was less marked than for proteoglycan concentrations. The serum concentrations were low in patients with juvenile chronic arthritis and in patients with RA with advanced cartilage destruction of the studied knee joint. In the other groups serum levels did not differ between groups or from controls.},
  author       = {Saxne, Tore and Heinegård, Dick},
  keyword      = {Arthritis/blood,Proteoglycans/blood,Synovial Fluid/metabolism},
  language     = {eng},
  number       = {9},
  pages        = {583--591},
  publisher    = {ARRAY(0x90ab7f8)},
  series       = {British Journal of Rheumatology},
  title        = {Cartilage oligomeric matrix protein. A novel marker of cartilage turnover detectable in synovial fluid and blood},
  volume       = {31},
  year         = {1992},
}