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Platelets and the immune continuum

Semple, John W LU ; Italiano, Joseph E and Freedman, John (2011) In Nature Reviews Immunology 11(4). p.74-264
Abstract

Platelets are anucleate cells that are crucial mediators of haemostasis. Most immunologists probably don't think about platelets every day, and may even consider these cells to be 'nuisances' in certain in vitro studies. However, it is becoming increasingly clear that platelets have inflammatory functions and can influence both innate and adaptive immune responses. Here, we discuss the mechanisms by which platelets contribute to immunity: these small cells are more immunologically savvy than we once thought.

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author
publishing date
type
Contribution to journal
publication status
published
keywords
Adaptive Immunity, Animals, Atherosclerosis, Birds, Blood Platelets, Communicable Diseases, Cytokines, Hematopoiesis, Hemostasis, Humans, Immunity, Innate, Inflammation, Mice, Platelet Count, Toll-Like Receptors, Journal Article, Review
in
Nature Reviews Immunology
volume
11
issue
4
pages
11 pages
publisher
Nature Publishing Group
external identifiers
  • Scopus:79953150620
ISSN
1474-1741
DOI
10.1038/nri2956
language
English
LU publication?
no
id
76b327e7-614e-4f8a-91e0-5971533aaccf
date added to LUP
2016-09-23 12:04:54
date last changed
2016-12-04 04:54:13
@misc{76b327e7-614e-4f8a-91e0-5971533aaccf,
  abstract     = {<p>Platelets are anucleate cells that are crucial mediators of haemostasis. Most immunologists probably don't think about platelets every day, and may even consider these cells to be 'nuisances' in certain in vitro studies. However, it is becoming increasingly clear that platelets have inflammatory functions and can influence both innate and adaptive immune responses. Here, we discuss the mechanisms by which platelets contribute to immunity: these small cells are more immunologically savvy than we once thought.</p>},
  author       = {Semple, John W and Italiano, Joseph E and Freedman, John},
  issn         = {1474-1741},
  keyword      = {Adaptive Immunity,Animals,Atherosclerosis,Birds,Blood Platelets,Communicable Diseases,Cytokines,Hematopoiesis,Hemostasis,Humans,Immunity, Innate,Inflammation,Mice,Platelet Count,Toll-Like Receptors,Journal Article,Review},
  language     = {eng},
  number       = {4},
  pages        = {74--264},
  publisher    = {ARRAY(0x9476ae8)},
  series       = {Nature Reviews Immunology},
  title        = {Platelets and the immune continuum},
  url          = {http://dx.doi.org/10.1038/nri2956},
  volume       = {11},
  year         = {2011},
}