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The role of NADP in the mitochondrial matrix

Møller, Ian M. and Rasmusson, Allan G. LU (1998) In Trends in Plant Science 3(1). p.21-27
Abstract

Many diverse metabolic processes are coupled to the turnover of the coenzyme NADP in the matrix of plant mitochondria. NADPH can be produced via the NADP-specific isocitrate dehydrogenase as well as via enzymes like NAD-malic enzyme, NAD-malate dehydrogenase and Δ1-pyrroline-5-carboxylate dehydrogenase. Although not NADP-specific, the latter enzymes can all catalyse the reduction of NADP+ at appreciable rates. The NADPH produced can be used in folate metabolism, by glutathione reductase for protection against oxidative damage, and by thioredoxin reductase in the (putative) regulation of metabolic pathways via thiol-group reduction. It can also be oxidized by the respiratory chain via a Ca2+-dependent... (More)

Many diverse metabolic processes are coupled to the turnover of the coenzyme NADP in the matrix of plant mitochondria. NADPH can be produced via the NADP-specific isocitrate dehydrogenase as well as via enzymes like NAD-malic enzyme, NAD-malate dehydrogenase and Δ1-pyrroline-5-carboxylate dehydrogenase. Although not NADP-specific, the latter enzymes can all catalyse the reduction of NADP+ at appreciable rates. The NADPH produced can be used in folate metabolism, by glutathione reductase for protection against oxidative damage, and by thioredoxin reductase in the (putative) regulation of metabolic pathways via thiol-group reduction. It can also be oxidized by the respiratory chain via a Ca2+-dependent NADPH dehydrogenase - this is a potential way of regulating the NADP reduction level in the matrix and thus, indirectly, the other processes. It is now possible to present an integrated picture of NADP turnover inside the mitochondrion.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Trends in Plant Science
volume
3
issue
1
pages
7 pages
publisher
Elsevier
external identifiers
  • Scopus:0031952559
ISSN
1360-1385
DOI
10.1016/S1360-1385(97)01156-4
language
English
LU publication?
yes
id
76c6aa77-a30f-4111-9c5a-ad7d2c3ee78f
date added to LUP
2016-05-31 21:29:12
date last changed
2016-10-13 05:09:36
@misc{76c6aa77-a30f-4111-9c5a-ad7d2c3ee78f,
  abstract     = {<p>Many diverse metabolic processes are coupled to the turnover of the coenzyme NADP in the matrix of plant mitochondria. NADPH can be produced via the NADP-specific isocitrate dehydrogenase as well as via enzymes like NAD-malic enzyme, NAD-malate dehydrogenase and Δ<sup>1</sup>-pyrroline-5-carboxylate dehydrogenase. Although not NADP-specific, the latter enzymes can all catalyse the reduction of NADP<sup>+</sup> at appreciable rates. The NADPH produced can be used in folate metabolism, by glutathione reductase for protection against oxidative damage, and by thioredoxin reductase in the (putative) regulation of metabolic pathways via thiol-group reduction. It can also be oxidized by the respiratory chain via a Ca<sup>2+</sup>-dependent NADPH dehydrogenase - this is a potential way of regulating the NADP reduction level in the matrix and thus, indirectly, the other processes. It is now possible to present an integrated picture of NADP turnover inside the mitochondrion.</p>},
  author       = {Møller, Ian M. and Rasmusson, Allan G.},
  issn         = {1360-1385},
  language     = {eng},
  number       = {1},
  pages        = {21--27},
  publisher    = {ARRAY(0x9e01b48)},
  series       = {Trends in Plant Science},
  title        = {The role of NADP in the mitochondrial matrix},
  url          = {http://dx.doi.org/10.1016/S1360-1385(97)01156-4},
  volume       = {3},
  year         = {1998},
}