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Antiproliferative effects of curcumin analog L49H37 in pancreatic stellate cells: a comparative study.

Gundewar, Chinmay LU ; Ansari, Daniel LU ; Tang, Longguang; Wang, Yi; Liang, Guang; Rosendahl, Ann LU ; Saleem, Moin A and Andersson, Roland LU (2015) In Annals of gastroenterology : quarterly publication of the Hellenic Society of Gastroenterology 28(3). p.391-398
Abstract
Pancreatic cancer is a devastating disease with poor prognosis. It is characterized by a pronounced stromal reaction, which resists chemotherapeutics and effective tumor treatment. Pancreatic stellate cells (PSCs) are mainly responsible for this stromal reaction. Moreover, the cancer and stromal interaction seems to promote tumor proliferation. In this study, L49H37, a newly synthesized curcumin analog, was used as intervention to target the stromal compartment of pancreatic cancer.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Annals of gastroenterology : quarterly publication of the Hellenic Society of Gastroenterology
volume
28
issue
3
pages
391 - 398
publisher
Hellenic Society of Gastroenterology
external identifiers
  • PMID:26129848
  • Scopus:84931376925
ISSN
1108-7471
language
English
LU publication?
yes
id
df1d2b15-54c9-43bf-896b-d6501ce13db5 (old id 7751379)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26129848?dopt=Abstract
date added to LUP
2015-08-01 20:56:44
date last changed
2016-10-13 04:27:15
@misc{df1d2b15-54c9-43bf-896b-d6501ce13db5,
  abstract     = {Pancreatic cancer is a devastating disease with poor prognosis. It is characterized by a pronounced stromal reaction, which resists chemotherapeutics and effective tumor treatment. Pancreatic stellate cells (PSCs) are mainly responsible for this stromal reaction. Moreover, the cancer and stromal interaction seems to promote tumor proliferation. In this study, L49H37, a newly synthesized curcumin analog, was used as intervention to target the stromal compartment of pancreatic cancer.},
  author       = {Gundewar, Chinmay and Ansari, Daniel and Tang, Longguang and Wang, Yi and Liang, Guang and Rosendahl, Ann and Saleem, Moin A and Andersson, Roland},
  issn         = {1108-7471},
  language     = {eng},
  number       = {3},
  pages        = {391--398},
  publisher    = {ARRAY(0x9933138)},
  series       = {Annals of gastroenterology : quarterly publication of the Hellenic Society of Gastroenterology},
  title        = {Antiproliferative effects of curcumin analog L49H37 in pancreatic stellate cells: a comparative study.},
  volume       = {28},
  year         = {2015},
}